Innervation of the Human Uterine Artery and Contractile Responses to Neuropeptides

Ekesbo, Rickard; Alm, Per; Ekström, Per; Lundberg, Lena-Maria; Åkerlund, Mats

doi:10.1159/000293096

Cited by 37 publications

(17 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that arginine vasopressin (AVP) induces contraction of the human uterine artery (Svane et al, 1990;Ekesbo et al, 1991;Nelson & Suresh, 1992;Kostrzewska et al, 1993), as opposed to some other arteries in which AVP evokes relaxation (Katusic et al, 1984;Seino et al, 1985;Evora et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Characterization of arginine vasopressin actions in human uterine artery: lack of role of the vascular endothelium

Jovanović

Grbović

Žikić

et al. 1995

British J Pharmacology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Characterization of arginine vasopressin actions in human uterine artery: lack of role of the vascular endothelium

Jovanović

Grbović

Žikić

et al. 1995

British J Pharmacology

View full text Add to dashboard Cite

“…Dopamine stimulates uterine contractility in rabbits, rats and women in early pregnancy (L a l and Sharma 1983;Sizov 1992;Urban et al 1982;Ekesbo et al 1991). It blocks muscle relaxation effect caused by releasing relaxin during parturition (Sizov 1992).…”

Section: Discussionmentioning

confidence: 99%

Influence of Dopamine on Rat Uterine Motility in vitro

Czerski¹,

Zawadzki²,

Zawadzki³

et al. 2005

Acta Vet. Brno

View full text Add to dashboard Cite

Czerski A., W. Zawadzki, M. Zawadzki, Z. Czerska: Influence of Dopamine on Rat Uterine Motility in vitro. Acta Vet. Brno 2005, 74: 9-15.The effect of dopamine on spontaneous rhythmic contractions of isolated rat uterine muscles was examined. The experiments were carried out on 25 female Buffalo rats aged between 4-6 months. Myometrial tissue (1.5-2 cm long) was set up in 4 isolated organ baths (20 ml) at 37 °C. After recording the pattern of myometrial tissue spontaneous motility: dopamine, domperidone, metoclopramide, clozapine, bromocriptine, prazosine, propranolol were added into the organ baths. The dose of the formulae was fixed in preliminary experiments. Myometrial strips incubated in the isolated organ baths had spontaneous motility for about 8 to 12 h. The spontaneous motility frequency amounted to about 1.15 ± 0.38 contractions per min. The contraction strength was on average 2.8 ± 0.45 grams.The addition of dopamine into the incubation bath organ at a concentration of 1.3·10 -4 mol/L significantly reduced the strength (63%, p < 0.001, to the value of 1.04 ± 0.18 grams) and frequency (27%, p < 0.01, to the value 0.84 ± 0.21 per minute) of spontaneous rhythmic contractions. The addition of dopamine at a concentration of 2.6·10 -4 mol/L totally inhibited the uterine spontaneous contractions. The attempt at blocking dopaminergic receptors with metoclopramide, domperidone and clozapine did not prevent uterus atony caused by the addition of dopamine. Uterus contractility was not affected by activating dopaminergic receptors with bromocriptine D 1 and D 2 receptors agonist, and the obtained recording exhibited no statistically significant differences in comparison to the initial recording. Simultaneous blocking of α 1 adrenergic receptors with prazosine and β adrenergic receptors with propranolol counteracted uterus atony after the addition of dopamine to the incubation bath organ.The results indicated a blocking influence of dopamine on uterus contractility in rats in vitro related to a concentration of dopamine and caused by activating adrenergic receptors with dopamine.

show abstract

“…AVP and norepinephrin/noradrenaline cause uterine artery constriction [513], which may lead to hypoxemia and induction of CRH [514]. Uterine vasoconstriction (i.e.…”

Section: Stress and The Hpa Axismentioning

confidence: 99%

Preterm Birth: A Review

Schellenberg

2006

CWHR

View full text Add to dashboard Cite

Preterm birth at less than 37 weeks gestation is a substantial burden to the community, representing a major source of infant death, severe handicap, and suffering for both victims and their families. Despite considerable research, little progress has been made in its prevention, partly because preterm birth is the endpoint of a silent multifactorial syndrome which begins long before labour starts. Infectious inflammation often plays a central role, but maternal susceptibility is probably also critical. Although progestogen treatment is preventive in some women with a prior history of preterm birth this will have little impact on the overall preterm birth rate unless effective treatment can be used in a much larger population of at risk women. An accurate screening test to identify such women is needed. The discovery of a screening test and of novel treatments requires a better understanding of the underlying biomolecular events. This paper gives an overview of the physiology and molecular biology of normal and abnormal pregnancy and parturition, the causes and consequences of preterm birth, and the difficulties of predicting and preventing preterm birth.

show abstract

Innervation of the Human Uterine Artery and Contractile Responses to Neuropeptides

Cited by 37 publications

References 18 publications

Characterization of arginine vasopressin actions in human uterine artery: lack of role of the vascular endothelium

Characterization of arginine vasopressin actions in human uterine artery: lack of role of the vascular endothelium

Influence of Dopamine on Rat Uterine Motility in vitro

Preterm Birth: A Review

Contact Info

Product

Resources

About