Innervation of the Cerebral Dura Mater

Lv, Xianli; Wu, Zhongxue; Li, Youxiang

doi:10.15274/nrj-2014-10052

Cited by 49 publications

(47 citation statements)

References 31 publications

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“…19 Other studies found the DACF and the tentorium cerebelli were innervated by nerve fibers of the ophthalmic division in humans and other primates. 15,20 Our result is consistent with previous studies on innervation of the dura mater.…”

Section: Discussionsupporting

confidence: 93%

“…15,20 If a connection between the PANs innervating the IWAEC and the dura mater really exists, it is most likely constituted by neurons in the same ophthalmic region, so we investigated the somatotopic organization of the DACF in rats first. Nine days after application of FAST Dil on the DACF, the red FAST Dil-labeled neurons could be observed in the medial part of the ipsilateral TG (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In rabbits, the TG has only two lobes, a mandibular and a maxillary-ophthalmic, 22 while in rats and humans, the TG has three lobes, an ophthalmic, a maxillary, and a mandibular. 23 Previous studies have found that there is a high homology between rats and humans in trigeminal innervation, 19,15,20 so rats are considered as a valid model to study the anatomic and functional characteristics of trigeminal innervation in humans. In this study, retrograde neuronal tracing revealed PANs innervating the DACF exclusively in the medial part of the TG.…”

Section: Discussionmentioning

confidence: 99%

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Anatomic Evidence for Information Exchange between Primary Afferent Sensory Neurons Innervating the Anterior Eye Chamber and the Dura Mater in Rat

Liu

Zhu

Ling

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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Citation: Liu H, Zhu X, Ling Y, et al. Anatomic evidence for information exchange between primary afferent sensory neurons innervating the anterior eye chamber and the dura mater in rat. Invest Ophthalmol Vis Sci. 2018;59:3424-3430. https://doi.org/ 10.1167/iovs.18-24308 PURPOSE. Our previous studies suggested that mechanosensitive trigeminal ganglion (TG) nerve endings innervating the inner wall of the anterior eye chamber (IWAEC) might play a role in baroreception of the IOP. It has been reported that mechanosensitive TG nerve endings also innervate the dura mater. An acute IOP elevation evokes eye pain accompanied by an ipsilateral headache, suggesting that information exchange may occur between the primary afferent neurons (PANs) innervating the IWAEC and the dura mater. To verify the information exchange between PANs of the two locations, we investigated the anatomic connection between them.METHODS. Non-trans-synaptic tracers, 1,1 0 -dilinoleyl-3,3,3 0 ,3 0 -tetramethylindo-carbocyanine, 4-chlorobenzenesulfonate (FAST Dil) and cholera toxin subunit-B with a 488-nm fluorescent tag (CTB-488), were applied to the dura of the anterior cranial fossa (DACF) and the anterior eye chamber (AEC) to label the PANs. A trans-synaptic tracer, GFP-expressing pseudorabies virus (PRV152), was injected into the AEC while FAST Dil was applied to the DACF to explore the connection between PANs. Fluorescent localization in the TG was studied with a confocal fluorescent microscope.RESULTS. Nine days after rats were treated with CTB-488 in the AEC and FAST Dil on the DACF, FAST Dil-labeled (red), and CTB-488-labeled (green) TG neurons were observed in the medial part of the TG, while double-labeled neurons were absent. If PRV152 was used to substitute CTB-488, then FAST Dil (red) and PRV152 (green) double-labeled TG neurons and axons were observed 3 days later. CONCLUSIONS.Our results indicate that synapses exist between PANs of the IWAEC and the DACF, providing anatomic evidence for information exchange between them.Keywords: IOP, trigeminal ganglion, dura mater, anterior cranial fossa, anterior eye chamber, primary afferent neuron T he lamina cribrosa forms the interface between the intraocular compartment and the retrobulbar compartment. Because the optic nerve is part of the central nervous system, it is surrounded by meninges and cerebrospinal fluid (CSF).1,2 The translaminar pressure difference (TPD) is defined as the difference between the IOP and the intracranial pressure (ICP).1,2 Any change in one of them can be associated with a disturbance of homeostasis of the optic nerve head, such as papilledema or glaucomatous optic neuropathy.The IOP and ICP systems are relatively independent pressure systems, which keep themselves in a relatively stable state through aqueous and CSF circulations.1-3 Significant correlations between the IOP and ICP have been widely reported. However, mechanisms by which the organism maintains the balance between the IOP and ICP have so far remained elusive. 1,3,4 In a recent experimental study, ...

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Section: Discussionsupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anatomic Evidence for Information Exchange between Primary Afferent Sensory Neurons Innervating the Anterior Eye Chamber and the Dura Mater in Rat

Liu

Zhu

Ling

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…Previous studies have shown that the trigeminal nerve supplies the cranial dura mater both in humans and in animal models (Lv et al. ; Dach et al. ).…”

Section: Introductionmentioning

confidence: 99%

Visualization of the tentorial innervation of human dura mater

2017

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Posterior projections of the ophthalmic division of the trigeminal nerve (the ophthalmic nerve) are distributed in the tentorium cerebelli as recurrent meningeal branches. We investigated the morphological tentorial distribution of the ophthalmic nerve. Fifty-two sides of the tentorium cerebelli and adjacent dura mater obtained from 29 human specimens were stained using Sihler's method to examine the nerve fibres in the dural sheets. The innervation patterns of the tentorium cerebelli were classified into the following four types according to their distributions: Type 1, where nerve fibres projected to both the straight and transverse sinuses; Type 2, where nerve fibres projected only to the transverse sinus and lateral convexity; Type 3, where nerve fibres projected medially only to the straight sinus and the posterior part of the falx cerebri; and Type 4, where the nerve fibres terminated within the tentorium cerebelli. Images of the tentorium cerebelli were superimposed to identify areas of dense innervation. The incidence rates of Types 1-4 were 71.2% (n = 37), 21.2% (n = 11), 3.8% (n = 2) and 3.8% (n = 2), respectively. More branches of nerve fibres traversed towards the transverse sinus posterolaterally than towards the straight sinus medially. The space between the anterior half of the straight sinus and the medial tentorial notch can be considered a safe surgical area where innervation is scarce. The posterior part of the falx cerebri was innervated by the ophthalmic nerve that traversed to the straight sinus. The parietal branches of the middle meningeal artery in the lateral convexity that were projected orthogonally by the ophthalmic nerve traversed the transverse sinus, implicating their vulnerability and possible sensitivity under physiological or neurosurgical conditions. This study has revealed the macroscopic tentorial innervation of the dura mater in humans, which could be useful information for both neurosurgeons and neurologists.

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“…With regard to the innervation of the dura mater, the afferent nerve fibers for the anterior membrane originate from the ipsilateral trigeminal ganglion . These nerve fibers course alongside the branches of the MMA along the dura . In this patient, embolization of the MMA led to an acute resolution of headaches within 24 hours – possibly due to deinnervation of the nerve fibers along the dura secondary to ischemia – well before the hematoma radiographically resolved.…”

mentioning

confidence: 99%