Inner hair cell responses to the velocity of basilar membrane motion in the guinea pig

Nuttall, Alfred L.; Brown, M. Christian; Masta, Robert I.; Lawrence, Merle

doi:10.1016/0006-8993(81)90078-0

Cited by 59 publications

(20 citation statements)

References 5 publications

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“…Open and filled symbols represent the apical-and basal-turn IHCs, respectively. tials recorded in vivo using sharp electrodes also show a phase lead approaching 0.25 cycle (90°) relative to BM displacement (Nuttall et al, 1981;Russell and Sellick, 1983;Dallos, 1985). These results are consistent with the notion that the IHC hairbundle displacement is related to BM velocity at low frequencies (Dallos et al, 1972).…”

Section: Input-output Functions Of Ihc Transducer Currentssupporting

confidence: 84%

“…As we show above (Crawford et al, 1991;Ricci et al, 2005), resting open probability of the MET channels is greater in low external Ca 2ϩ (Ricci et al, 1998). IHC receptor potentials recorded in vivo using sharp electrodes show a phase lead relative to BM displacement (Nuttall et al, 1981;Russell and Sellick, 1983;Dallos, 1985). We examined the phase relationship between the transducer current and BM displacement.…”

Section: Input-output Functions Of Ihc Transducer Currentsmentioning

confidence: 82%

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Mechanoelectric Transduction of Adult Inner Hair Cells

Song¹,

Dallos

He³

2007

J. Neurosci.

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Inner hair cells (IHCs) are the true sensory receptors in the cochlea; they transmit auditory information to the brain. IHCs respond to basilar membrane (BM) vibration by producing a transducer current through mechanotransducer (MET) channels located at the tip of their stereocilia when these are deflected. The IHC MET current has not been measured from adult animals. We simultaneously recorded IHC transducer currents and BM motion in a gerbil hemicochlea to examine relationships between these two variables and their variation along the cochlear length. Results show that although maximum transducer currents of IHCs are uniform along the cochlea, their operating range is graded and is narrower in the base. The MET current displays adaptation, which along with response magnitude depends on extracellular calcium concentration. The rate of adaptation is invariant along the cochlear length. We introduce a new method of measuring adaptation using sinusoidal stimuli. There is a phase lead of IHC transducer currents relative to sinusoidal BM displacement, reflecting viscoelastic coupling of their cilia and their adaptation process.

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Section: Input-output Functions Of Ihc Transducer Currentssupporting

confidence: 84%

Section: Input-output Functions Of Ihc Transducer Currentsmentioning

confidence: 82%

Mechanoelectric Transduction of Adult Inner Hair Cells

Song¹,

Dallos

He³

2007

J. Neurosci.

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“…Nevertheless, model responses to sinusoidal stereocilia displacement may still be directly compared against corresponding IHC responses to sound provided that the latter come from basal cells stimulated with low-frequency pure tones. In those cases, it is reasonable to assume that the basilar membrane responses are proportional to the acoustic pressure (evidence reviewed by Robles and Ruggero 2001), and that stereocilia displacement is proportional to basilar membrane displacement (at least for stimulation frequencies above around 300 Hz; see Nuttall et al 1981). In short, in those cases, it may be assumed that the stereocilia displacement is approximately proportional (thus linearly related) to the acoustic pressure.…”

Section: In Vivo Responses To Sinusoidal Stereocilia Displacementmentioning

confidence: 99%

A Biophysical Model of the Inner Hair Cell: The Contribution of Potassium Currents to Peripheral Auditory Compression

Lopez‐Poveda

Eustaquio-Martín

2006

JARO

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The term peripheral auditory compression refers to the fact that the whole range of audible sound pressure levels is mapped into a narrower range of auditory nerve responses. Peripheral compression is the by-product of independent compressive processes occurring at the level of the basilar membrane, the inner hair cell (IHC), and the auditory nerve synapse. Here, an electrical-circuit equivalent of an IHC is used to look into the compression contributed by the IHC. The model includes a mechanically driven transducer potassium (K + ) conductance and two time-and voltage-dependent basolateral K + conductances: one with fast and one with slow kinetics. Special attention is paid to faithfully implement the activation kinetics of these basolateral conductances. Optimum model parameters are provided to account for previously reported in vitro observations that demonstrate the compression associated with the gating of the transducer and of the basolateral channels. Without having to readjust its parameters, the model also accounts for the in vivo nonlinear IHC transfer characteristics. Model simulations are then used to investigate the relative contribution of the transducer and basolateral K + currents to the nonlinear IHC input/output functions in vivo. The simulations suggest that the voltage-dependent activation of the basolateral currents compresses the DC potential for stereocilia displacements above approximately 5 nm. The degree of compression exceeds 2-to-1 and is similar for all stimulation frequencies. The AC potential is compressed in a similar way, but only for frequencies below 800 Hz. The simulations further suggest that the nonlinear gating of the transducer current is responsible for the expansive growth of the DC potential with increasing sound level (slope of 2 dB/dB) at low sound pressure levels.

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“…In fact, however, there is evidence that a 'second filter' is interposed between basilar membrane displacement, on the one hand, and inner hair cell depolarization or neural excitation, on the other. Such a high-pass filter is evident in the AC receptor potentials of inner hair cells, which at low frequencies (< 500 Hz or so) are proportional to, and in phase with, basilar membrane velocity (Sellick and Russell, 1980;Nuttall et al, 1981;Dallos and Santos-Sacchi, 1983;Russell and Sellick, 1983). We suggest that some form of high-pass filtering extends to relatively high frequencies, perhaps CF, thus permitting suppression to be induced by non-excitatory low-frequency tones (Ruggero et al, , p. 1096Cooper, 1996, pp.…”

Section: Is There a Synaptic Suppression Mechanism That Is Especiallymentioning

confidence: 99%

Low-frequency suppression of auditory nerve responses to characteristic frequency tones

Temchin

Rich

1997

Hearing Research

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The effects of low-frequency (50, 100, 200 and 400 Hz) 'suppressor' tones on responses to moderate-level characteristic frequency (CF) tones were measured in chinchilla auditory nerve fibers. Two-tone interactions were evident at suppressor intensities of 70-100 dB SPL. In this range, the average response rate decreased as a function of increasing suppressor level and the instantaneous response rate was modulated periodically. At suppression threshold, the phase of suppression typically coincided with basilar membrane displacement toward scala tympani, regardless of CF. At higher suppressor levels, two suppression maxima coexisted, synchronous with peak basilar membrane displacement toward scala tympani and scala vestibuli. Modulation and rate-suppression thresholds did not vary as a function of spontaneous activity and were only minimally correlated with fiber sensitivity. Except for fibers with CF < 1 kHz, modulation and rate-suppression thresholds were lower than rate and phase-locking thresholds for the suppressor tones presented alone. In the case of high-CF fibers with low spontaneous activity, excitation thresholds could exceed suppression thresholds by more than 30 dB. The strength of modulation decreased systematically with increasing suppressor frequency. For a given suppressor frequency, modulation was strongest in high-CF fibers and weakest in low-CF fibers. The present findings strongly support the notion that low-frequency suppression in auditory nerve fibers largely reflects an underlying basilar membrane phenomenon closely related to compressive non-linearity.

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Inner hair cell responses to the velocity of basilar membrane motion in the guinea pig

Cited by 59 publications

References 5 publications

Mechanoelectric Transduction of Adult Inner Hair Cells

Mechanoelectric Transduction of Adult Inner Hair Cells

A Biophysical Model of the Inner Hair Cell: The Contribution of Potassium Currents to Peripheral Auditory Compression

Low-frequency suppression of auditory nerve responses to characteristic frequency tones

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