Inner Ear Hemorrhage in Systemic Lupus Erythematosus

Abstract

A 33-year-old man had systemic lupus erythematosus (SLE) with anticardiolipin antibody. At the age of 40 years, he experienced bilateral hearing deterioration. The three-dimensional fluid-attenuated inversion recovery of magnetic resonance imaging showed high signals bilaterally in the cochlea and vestibule. He was diagnosed with bilateral inner ear hemorrhage on the basis of the presence of anticardiolipin antibody. This is the first published case of inner ear hemorrhage in a patient with SLE. Our findings suggest that inner ear hemorrhage is associated with hearing deterioration in some patients with SLE.

Comparison of Contrast Effect on the Cochlear Perilymph after Intratympanic and Intravenous Gadolinium Injection

“…[4][5][6] In addition, increased signal intensity of the diseased inner ear can also be observed on 3D-FLAIR imaging shortly after IV gadolinium injection; this technique has been reported to be useful for pathophysiologic analysis of the inner ear in many auditory diseases, such as sudden SNHL, cholesteatoma, cochlear otosclerosis, and vestibular schwannoma. [7][8][9][10] 3D-FLAIR imaging 24 hours after intratympanic gadolinium injection (IT-method) has been reported to visualize perilymph and endolymph fluid separately and to enable preliminary prediction of drug distribution to the inner ear, such as gentamicin and steroids.…”

Clinical Significance of an Increased Cochlear 3D Fluid-Attenuated Inversion Recovery Signal Intensity on an MR Imaging Examination in Patients with Acoustic Neuroma

“…[13][14][15][16][17] Furthermore, 3D-FLAIR imaging can minimize the undesired inflow artifacts of CSF flow, has a higher signal-tonoise ratio and spatial resolution, and allows recognition of subtle compositional changes of the inner ear fluid. [18][19][20][21] Therefore, one can assume that the increased protein content in the cochlear perilymph of patients with ANs can be detected on 3D FLAIR imaging with a high sensitivity and good spatial resolution. Several researchers recently investigated whether there was a correlation between the increased cochlear FLAIR signal in patients with ANs and the degree of their hearing disturbance.…”

Detection of Presumed Hemorrhage in the Ampullar Endolymph of the Semicircular Canal: A Case Report

“…Labyrinthine hemorrhage has been attributed to coagulopathy, tumor, trauma, viral labyrinthitis, seroˆbrinoid labyrinthitis after stapes surgery, cholesterol granuloma, lupus erythematosus, and other causes. 5,18 3D-FLAIR is more sensitive than T1-weighted imaging in detecting subtle compositional changes of lymph ‰uid. 4 In the present case, focal hemorrhage of the inner ear, which might have been overlooked on T1-weighted images, could be detected by adding 3D-FLAIR.…”

“…[1][2][3][4][5][6] Combined with intratympanic Gd-DTPA administration, 3D-FLAIR has enabled separate visualization of endoand perilymph ‰uid. 7 In an exceptional case of enlarged endolymphatic duct and sac syndrome, 3D-FLAIR without contrast revealed endolymphatic hydrops by visualizing the re‰ux of hemorrhagic ‰uid from the enlarged sac to the cochlea and vestibule.…”