Inner Ear Damage Secondary to Diabetes Mellitus: II. Changes in Aging SHR/N-cp Rats

Rust, Kevin R.; Prazma, Jiri; Triana, Rudolph J.; Michaelis, Otho E.; Pillsbury, Harold C.

doi:10.1001/archotol.1992.01880040059010

Cited by 54 publications

(54 citation statements)

References 13 publications

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“…The increase in hearing threshold is attributed to microvascular angiopathy occurring in capillaries of stria vascularis which make these vessels thicker than normal. These changes can occur in vessels supplying other parts of auditory system as well [14]. Older diabetic patients had higher incidence of hearing loss and they had severe grade hearing loss.…”

Section: Resultsmentioning

confidence: 99%

Clinical Study to Evaluate the Association Between Sensorineural Hearing Loss and Diabetes Mellitus in Poorly Controlled Patients Whose HbA1c >8

Srinivas

Shyamala

Kumar

2016

Indian J Otolaryngol Head Neck Surg

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The relationship between sensorineural hearing loss (SNHL) and Diabetes mellitus has been known since more than 150 years. The pathophysiology of diabetes related hearing loss is speculative. Hearing loss is usually, bilateral, gradual onset, affecting higher frequencies. This study aims at knowing the prevalence of SNHL in DM and its relation to age, sex, duration of DM and control of DM. A total of 50 type 2 diabetics of age group 30-65 years were involved in the study. FBS, PPBS, HbA1c of all the subjects were done and later subjected to PTA. The type and severity of hearing loss was noted. Occurrence of SNHL was later compared with age, sex, duration, and control of DM. Sensorineural hearing loss was found in 66 % of type II diabetic patients and 34 % were found normal. Out of 50 diabetes mellitus patients, 33 patients had SNHL. All cases of SNHL detected were of gradual in onset and no one had hearing loss of sudden onset. Normal hearing was found in 34 % of patients, whereas 54 % of patients had mild hearing loss and 12 % of patients had moderate hearing loss. Association of hearing loss of DM patients with sex of the patient is insignificant. However there is significant association between older age group, longer duration and uncontrolled DM with that of SNHL. In subjects with HbA1c more than 8 and duration of diabetes mellitus more than 10 years prevalence of SNHL is more than 85 %, which is statistically significant. Sensorineural hearing loss in diabetes mellitus is gradually progressive involving high frequency thresholds. Hearing threshold increases with increasing age duration of diabetes and also high level of HbA1c greater than 8 %.

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Section: Resultsmentioning

confidence: 99%

Clinical Study to Evaluate the Association Between Sensorineural Hearing Loss and Diabetes Mellitus in Poorly Controlled Patients Whose HbA1c >8

Srinivas

Shyamala

Kumar

2016

Indian J Otolaryngol Head Neck Surg

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“…Nevertheless, there are only few reports in the literature concerning the relationship between diabetes mellitus and ISSNHL. Rust et al [1992] found a relationship between type 2 diabetes and inner ear damage (loss of outer hair cells) related to hyperglycemia and to a genetic predisposition to glucose intolerance. Harmel et al [2002] reported that a decrease in plasma glucose levels primarily reduces the risk of microvascular disorder.…”

Section: Discussionmentioning

confidence: 99%

Diabetes, Cardiovascular Risk Factors and Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

et al. 2009

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Aims/Hypothesis: Idiopathic sudden sensorineural hearing loss (ISSNHL) represents an acute inner ear disorder with an overall incidence of 5–20/100000 individuals per year in western countries. No clear causes for this disease have been found so far, but cochlear ischemia has been hypothesized as one of the etiopathological mechanisms. The aim of our study was to assess the role of diabetes and traditional cardiovascular risk factors in the pathogenesis of ISSNHL. Materials/Methods: Case-control study of 141 patients (75 males/66 females) matched for age and gender. Cases were affected by ISSNHL, defined as a sudden hearing loss ≧30 dB, within 3 frequencies, developing over 72 h. The control group was composed of 271 sex- and age-matched subjects (142 males/129 females) who agreed to participate in this observational study and provided blood samples for laboratory investigations. Cardiovascular risk factors examined were: diabetes mellitus, smoking history, hypercholesterolemia, hypertriglyceridemia and hypertension. Results: On the univariate analysis, diabetes prevalence was higher in the ISSNHL group (15.6%) compared to controls (8.5%) (p = 0.03). Also hypercholesterolemia was significantly more frequent in the ISSNHL group compared to the control population. There were no statistically significant differences between the 2 populations concerning other cardiovascular risk factors. The risk of ISSNHL tended to increase as the number of cardiovascular risk factors increased (p for linear trend = 0.018). Conclusions: Our findings suggest that diabetes mellitus, hypercholesterolemia and a high burden of cardiovascular risk factors are associated with the risk of ISSNHL.

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“…This may be an important etiologic factor in labyrinthine disorders 14 . The main proposed mechanisms are the interference on nutrient transportation through thickened capillary walls, flow reductions due to narrowed vessels, and secondary degeneration of the vestibulocochlear nerve causing neuropathy [15][16][17] .…”

Section: Causes Of Hearing Loss and Diabetes Mellitusmentioning

confidence: 99%

Estudo da prevalência de hipoacusia em indivíduos com diabetes mellitus tipo 1

Malucelli¹,

Malucelli²,

Fonseca³

et al. 2012

Braz. j. otorhinolaryngol.

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Diabetes mellitus (DM) is a chronic degenerative disease that impairs normal insulin production and use. DM chronic auditory complications may include spiral ganglion atrophy, degeneration of the vestibulocochlear nerve myelin sheath, reduction of the number of spiral lamina nerve fibers, and thickening of the capillary walls of the stria vascularis and small arteries. Objective This paper aims to verify the hearing thresholds of individuals with type 1 DM. Materials and Methods Sixty patients were enrolled in this trial and divided into case and control groups featuring diabetic and non-diabetic subjects respectively. All individuals were interviewed and underwent physical examination, ENT examination, and audiometric tests. Results Statistically significant difference was observed in hearing thresholds of case group subjects at 250, 500, 10,000, 11,200, 12,500, 14,000 and 16,000 Hz for both ears and ear average. Case group subjects had higher likelihood of having hypacusis at any frequency regardless of ear than controls. Conclusion Statistically significant differences were seen in the audiological findings of case group subjects when compared to controls. Thorough audiological examination including high frequency audiometry is required for subjects with diabetes mellitus type 1.

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Inner Ear Damage Secondary to Diabetes Mellitus: II. Changes in Aging SHR/N-cp Rats

Cited by 54 publications

References 13 publications

Clinical Study to Evaluate the Association Between Sensorineural Hearing Loss and Diabetes Mellitus in Poorly Controlled Patients Whose HbA1c >8

Clinical Study to Evaluate the Association Between Sensorineural Hearing Loss and Diabetes Mellitus in Poorly Controlled Patients Whose HbA1c >8

Diabetes, Cardiovascular Risk Factors and Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

Estudo da prevalência de hipoacusia em indivíduos com diabetes mellitus tipo 1

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