Inner ear contribution to bone conduction hearing in the human

Stenfelt, Stefan

doi:10.1016/j.heares.2014.12.003

Cited by 90 publications

(106 citation statements)

References 63 publications

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“…Figure 2 shows the impedance model of the inner ear used for the predictions. This model is essentially the same model used in a previous study (Stenfelt, 2015). In that study only predictions of the inner ear was computed (fluid inertia and inner ear compression).…”

Section: Ear Modelmentioning

confidence: 99%

“…To enable predictions from all five components, the model is slightly changed. Moreover, some of the parameters are updated compared to the parameters in the Stenfelt (2015) study. Table 1.…”

Section: Ear Modelmentioning

confidence: 99%

“…This depressed BC thresholds has been attributed to the lack of middle ear inertia (Tonndorf, 1966) as the ossicles resonance frequency for BC stimulation is close to 2 kHz (Homma et al, 2009;Stenfelt et al, 2002). However, in a model simulation of BC excitation of the inner ear (Stenfelt, 2015), the depressed BC thresholds close to 2 kHz could be simulated as a result of increased impedance at the oval window (OW). In those simulations, the effect of middle ear inertia was not included but the Carhart notch was seen as a result of increasing the impedance at the OW seen from inside the inner ear.…”

Section: Introductionmentioning

confidence: 99%

“…One way to circumvent this problem is to use a model that can simulate BC excitation. Several such models have been devised to investigate a specific aspect of BC stimulation, for example the occlusion effect (Brummund et al, 2014;Schroeter et al, 1986;Stenfelt et al, 2007), middle ear inertia (Homma et al, 2009;Williams et al, 1990), and inner ear fluid inertia and compression (Bohnke et al, 2006;Kim et al, 2011;Schick, 1991;Stenfelt, 2015). These models are often specific meaning they only investigate a single or a couple of phenomena and not the complete response of the ear to BC stimulation.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, an inner ear model for BC sound was presented that used excitation based on the motion of the inner ear boundary (Stenfelt, 2015). The motion of the surrounding bone was based on experimental investigations of bone vibration transmission in the skull base, and the model was able to simulate several experimental and clinical findings for BC sound reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Model predictions for bone conduction perception in the human

Stenfelt

2016

Hearing Research

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Five different pathways are often suggested as important for bone conducted (BC) sound: (1) sound pressure in the ear canal, (2) inertia of the middle ear ossicles, (3) inertia of the inner ear fluid, (4) compression of the inner ear space, and (5) pressure transmission from the skull interior. The relative importance of these pathways was investigated with an acousticimpedance model of the inner ear. The model incorporated data of BC generated ear canal sound pressure, middle ear ossicle motion, cochlear promontory vibration, and intracranial sound pressure. With BC stimulation at the mastoid, the inner ear inertia dominated the excitation of the cochlea but inner ear compression and middle ear inertia were within 10 dB for almost the entire frequency range of 0.1 to 10 kHz. Ear canal sound pressure gave little contribution at the low and high frequencies, but was around 15 dB below the total contribution at the mid frequencies. Intracranial sound pressure gave responses similar to the others at low frequencies, but decreased with frequency to a level of 55 dB below the total contribution at 10 kHz. When the BC inner ear model was evaluated against AC stimulation at threshold levels, the results were close up to approximately 4 kHz but deviated significantly at higher frequencies. 3 Highlights• A model for BC simulates the contribution from 5 components.• The inner ear compression and inertia and middle ear inertia are most important.• The contribution from intracranial sound pressure is insignificant at higher frequencies.• The model provides similar BM excitation for AC and BC threshold stimulation up to 4 kHz. KeywordsBone conduction, inner ear model, fluid inertia, inner ear compression, middle ear inertia

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Section: Ear Modelmentioning

confidence: 99%

Section: Ear Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Model predictions for bone conduction perception in the human

Stenfelt

2016

Hearing Research

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Hearing Preservation in Patients Who Undergo Labyrinthectomy and Translabyrinthine Procedures

Reddy

Yan

Liu

et al. 2020

JAMA Otolaryngol Head Neck Surg

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fluids, maintenance of a fluid-filled vestibule, and preservation of the cochlear nerve and its vasculature are believed to be necessary to retaining hearing after an inner-ear operation. However, some studies have reported no hearing loss despite the violation of the vestibule, questioning the importance of maintaining a fluid-filled vestibule in preserving hearing.OBJECTIVE To report on the preservation of hearing after a complete labyrinthectomy for Meniere disease and after disruption of the vestibule.EVIDENCE REVIEW This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. A search of PubMed, Scopus, Ovid, and Cochrane Library databases was conducted to identify English-language articles on hearing preservation after labyrinthectomy, published from 1947 through December 11, 2019. The search strategy used a combination of boolean operators and included the following Medical Subject Heading terms and keywords: hearing preservation, labyrinth surgery, labyrinthectomy, vestibule violation, vestibule disruption, translabyrinthine approach, schwannoma removal, and semicircular canal ablation. Studies that included disruption of the vestibule and hearing preservation were included.FINDINGS This systematic review identified 10 studies with 10 patients who underwent surgical removal of cholesteatoma or vestibular schwannoma and displayed postoperative hearing preservation. This study also reported on 1 patient with Meniere disease who retained hearing after undergoing a complete labyrinthectomy. Among these 11 patients, the mean (range) age was 45.1 (27-55) years, and 8 patients (73%) were women. Multiple theories exist that explain the mechanism behind hearing preservation, such as sealing of the ductus reuniens or closure of the remaining vestibule.CONCLUSIONS AND RELEVANCE This systematic review describes a set of patients who did not experience hearing loss after a labyrinthectomy or surgical violation of the vestibule, which seems to contradict prevailing principles for retaining hearing after inner-ear surgical procedures. This finding suggests that hearing preservation is possible after labyrinthine destruction despite the absence of a fluid-filled vestibule and that other mechanisms, such as occlusion of the ductus reuniens with granulation tissue or bone dust, may be sufficient to achieve that outcome.

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Indispensable Role of Ion Channels and Transporters in the Auditory System

Mittal

Aranke

Debs

et al. 2016

Journal Cellular Physiology

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Ear is a complex system where appropriate ionic composition is essential for maintaining the tissue homeostasis and hearing function. Ion transporters and channels present in the auditory system plays a crucial role in maintaining proper ionic composition in the ear. The extracellular fluid, called endolymph, found in the cochlea of the mammalian inner ear is particularly unique due to its electrochemical properties. At an endocochlear potential of about +80 mV, signaling initiated by acoustic stimuli at the level of the hair cells is dependent on the unusually high potassium (K ) concentration of endolymph. There are ion channels and transporters that exists in the ear to ensure that K is continually being cycled into the stria media endolymph. This review is focused on the discussion of the molecular and genetic basis of previously and newly recognized ion channels and transporters that support sensory hair cell excitation based on recent knock-in and knock-out studies of these channels. This article also addresses the molecular and genetic defects and the pathophysiology behind Meniere's disease as well as how the dysregulation of these ion transporters can result in severe defects in hearing or even deafness. Understanding the role of ion channels and transporters in the auditory system will facilitate in designing effective treatment modalities against ear disorders including Meniere's disease and hearing loss. J. Cell. Physiol. 232: 743-758, 2017. © 2016 Wiley Periodicals, Inc.

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Inner ear contribution to bone conduction hearing in the human

Cited by 90 publications

References 63 publications

Model predictions for bone conduction perception in the human

Model predictions for bone conduction perception in the human

Hearing Preservation in Patients Who Undergo Labyrinthectomy and Translabyrinthine Procedures

Indispensable Role of Ion Channels and Transporters in the Auditory System

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