Innate Type 2 Immunity Is Associated with Eosinophilic Pleural Effusion in Primary Spontaneous Pneumothorax

Kwon, Bo‐In; Hong, Seokchan; Shin, Kihyuk; Choi, Eun‐Hye; Hwang, Jiwon; Lee, Seung‐Hyo

doi:10.1164/rccm.201302-0295oc

Cited by 42 publications

(31 citation statements)

References 49 publications

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“…A recent study in patients with eosinophilic pleural effusion (EPE) associated with primary spontaneous pneumothorax (PSP) reported elevated expression of TSLP and IL-33 in the pleural fluid along with elevat-ed IL-5, eotaxin-3, and enhanced ILC2 responses (Kwon et al 2013). This study provokes the hypothesis that ILC2s may be the key driver of eosinophilia in the context of EPE and PSP.…”

Section: Ilc2s and Other Lung Diseasesmentioning

confidence: 80%

Group 2 Innate Lymphoid Cells in Health and Disease

Kim

Artis

2015

Cold Spring Harb Perspect Biol

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Group 2 innate lymphoid cells (ILC2s) play critical roles in anti-helminth immunity, airway epithelial repair, and metabolic homeostasis. Recently, these cells have also emerged as key players in the development of allergic inflammation at multiple barrier surfaces. ILC2s arise from common lymphoid progenitors in the bone marrow, are dependent on the transcription factors RORa, GATA3, and TCF-1, and produce the type 2 cytokines interleukin (IL)-4, IL-5, IL-9, and/or IL-13. The epithelial cell -derived cytokines IL-25, IL-33, and TSLP regulate the activation and effector functions of ILC2s, and recent studies suggest that their responsiveness to these cytokines and other factors may depend on their tissue environment. In this review, we focus on recent advances in our understanding of the various factors that regulate ILC2 function in the context of immunity, inflammation, and tissue repair across multiple organ systems.

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Section: Ilc2s and Other Lung Diseasesmentioning

confidence: 80%

Group 2 Innate Lymphoid Cells in Health and Disease

Kim

Artis

2015

Cold Spring Harb Perspect Biol

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“…34 Enhanced accumulations of ILC2s have been reported at sites of eosinophilic inflammation, including nasal polyps and sinus mucosa in patients with chronic rhinosinusitis, skin lesions in patients with atopic dermatitis, and pleural effusions from patients with spontaneous pneumothorax. [35][36][37] Recent studies have reported that ILC2s, with a greater capacity to produce IL-5 and IL-13 on stimulation with epithelium-derived cytokines ex vivo, are found in the blood of allergic asthmatic patients compared with healthy control subjects. 38 In addition, increased numbers of ILC2s are found in the bronchoalveolar lavage fluid of patients with severe asthma compared with those in disease-matched control subjects.…”

Section: Abbreviations Usedmentioning

confidence: 99%

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

Smith

Chen

Kjarsgaard

et al. 2016

Journal of Allergy and Clinical Immunology

395

368

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“…29–32 Here, to extend this investigation and to examine whether innate type 2 immune response and/or ILC2s can be used as a biomarker of human diseases, we performed a prospective study. We addressed two specific questions: First, because blood specimens are more widely available than tissue specimens in clinical studies, we evaluated whether the innate type 2 response can be observed and whether ILC2s can be identified in peripheral blood.…”

Section: Introductionmentioning

confidence: 99%

Enhanced innate type 2 immune response in peripheral blood from patients with asthma

Bartemes

Kephart

Fox

et al. 2014

Journal of Allergy and Clinical Immunology

340

322

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Background In mice, group 2 innate lymphoid cells (ILC2s) likely mediate helminth immunity, inflammation and tissue repair and remodeling. However, the involvement of ILC2s in human diseases, such as asthma, is not well understood. Objective The goals of this study were to investigate whether peripheral blood specimens can be used to monitor innate type 2 immunity in human subjects and to examine whether ILC2s are involved in human asthma. Methods Peripheral blood mononuclear cells (PBMCs) from subjects with allergic asthma (AA), subjects with allergic rhinitis (AR), or healthy controls (HC) were cultured in vitro with IL-25 or IL-33. Flow cytometry and cell sorting were used to identify, isolate, and quantitate ILC2s in PBMCs. Results Human PBMCs produced IL-5 and IL-13 when stimulated with IL-33 or IL-25 in the presence of IL-2 without antigens. In addition, IL-7 or thymic stromal lymphopoietin were able to replace IL-2. The cell population with phenotypic ILC2 characteristics, lineage−CD127+CRTH2+ cells, responded to IL-33 and produced large quantities of IL-5 and IL-13, but undetectable IL-4. PBMCs from subjects with AA produced significantly larger amounts of IL-5 and IL-13 in response to IL-25 or IL-33 compared to subjects with AR or HC. The prevalence of ILC2s in blood was greater in the AA group compared to the AR or HC groups. Conclusion Innate type 2 immune responses are increased in asthma but not in allergic rhinitis, suggesting potential differences in the immunopathogenesis of these diseases. Peripheral blood is useful for evaluating innate type 2 immunity in humans.

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Innate Type 2 Immunity Is Associated with Eosinophilic Pleural Effusion in Primary Spontaneous Pneumothorax

Abstract: Our results indicate that innate immune responses characterized by the production of IL-33, TSLP, and IL-5 are associated with the development of EPE in PSP by an ILC2-dependent and Th2-independent mechanism.

Cited by 42 publications

References 49 publications

Group 2 Innate Lymphoid Cells in Health and Disease

Group 2 Innate Lymphoid Cells in Health and Disease

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

Enhanced innate type 2 immune response in peripheral blood from patients with asthma

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