Innate Lymphoid Cells: New Targets for Cutaneous Squamous Cell Carcinoma Immunotherapy

Azin, Marjan; Demehri, Shadmehr

doi:10.1016/j.jid.2021.04.003

Cited by 3 publications

(5 citation statements)

References 14 publications

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“…Finally, in accordance with Das Mahapatra et al, the upregulation of genes involved in the immune response, such as the chemokines CCL5 (C-C motif chemokine ligand 5) or CXCL1 (C-X-C motif chemokine ligand 1) or IL4R were observed [ 20 ]. The tight association between SCC risk and immunosuppression stresses the pivotal role of the immune system in regulating SCC development and progression [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Study on Human Skin Samples: Identification of Two Subclasses of Actinic Keratoses

Dubois-Pot-Schneider

Khairallah

Brzenczek

et al. 2023

IJMS

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Actinic keratoses (AKs) are sun-damaged skin areas that affect 20% of the European adult population and more than 50% of people aged 70 years and over. There are currently no clinical or histological features allowing us to identify to which clinical class (i.e., regression or progression) an AK belongs. A transcriptomic approach seems to be a robust tool for AK characterization, but there is a need for additional studies, including more patients and elucidating the molecular signature of an AK. In this context, the present study, including the largest number of patients to date, is the first aiming at identifying biological features to objectively distinguish different AK signatures. We highlight two distinct molecular profiles: AKs featuring a molecular profile similar to squamous cell carcinomas (SCCs), which are called “lesional AKs” (AK_Ls), and AKs featuring a molecular profile similar to normal skin tissue, which are called “non-lesional AKs” (AK_NLs). The molecular profiles of both AK subclasses were studied, and 316 differentially expressed genes (DEGs) were identified between the two classes. The 103 upregulated genes in AK_L were related to the inflammatory response. Interestingly, downregulated genes were associated with keratinization. Finally, based on a connectivity map approach, our data highlight that the VEGF pathway could be a promising therapeutic target for high-risk lesions.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Study on Human Skin Samples: Identification of Two Subclasses of Actinic Keratoses

Dubois-Pot-Schneider

Khairallah

Brzenczek

et al. 2023

IJMS

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“…Furthermore, cetuximab, an epidermal growth factor receptor inhibitor that is effective in the treatment of advanced CSCC cases, exerts its effect in part due to NK cell activation 13,15 . Given this collective evidence, it is hypothesized that NK cell activation may be a novel therapeutic target for CSCC 16 . Although NK cell therapy for CSCC has not yet been studied in humans, in mouse models, induced NK deficiency resulted in increased CSCC tumor growth, and adoptive transfer of purified NK cells decreased tumor size 17,18 …”

Section: Nonmelanoma Skin Cancersmentioning

confidence: 99%

Section: Nonmelanoma Skin Cancersmentioning

confidence: 99%

“…13,15 Given this collective evidence, it is hypothesized that NK cell activation may be a novel therapeutic target for CSCC. 16 Although NK cell therapy for CSCC has not yet been studied in humans, in mouse models, induced NK deficiency resulted in increased CSCC tumor growth, and adoptive transfer of purified NK cells decreased tumor size. 17,18 Breast Carcinoma Breast cancer has historically been considered a cold tumor and evades the immune system through a variety of strategies that decrease NK cell activation.…”

Section: Nonmelanoma Skin Cancersmentioning

confidence: 99%

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Natural Killer Cell Recognition and Control of Epithelial Cancers

Pereira¹,

Carr

Gatti‐Mays

et al. 2022

Cancer J

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Natural killer (NK) cells possess an innate ability to recognize cancer and are key mediators of cytotoxic efficacy for anticancer antibodies. Recent advances in the ability to generate, qualify, and safely infuse NK cells have led to a wide variety of clinical trials in oncology. Although their efficacy is best established for liquid cancers, their potential application in solid cancers has received increased attention. Here, we provide general background across a disparate group of exemplary solid tumors for which there is evidence for an NK cell role, discuss NK cell recognition motifs specific to each and murine and human studies of each that are supportive of NK cell adoptive immunotherapy, and end with special considerations relevant to the solid tumor microenvironment.

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“…Squamous cell carcinoma (SCC) encompasses a variety of tumors originating in various anatomical locations, characterized by shared genetic mutations and expressions of squamous differentiation markers. Among the multiple types of SCC, cutaneous squamous cell carcinoma (cSCC), an invasive and metastatic form originating from keratinocytes, is the second most common cutaneous neoplasm diagnosed in dogs [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Expression Levels of Epidermal Growth Factor Receptor, Cyclooxygenase-2, and Ki-67 in Canine Cutaneous Squamous Cell Carcinomas

Luís,

Files,

Cardoso

et al. 2024

CIMB

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Squamous cell carcinoma (SCC) stands as the second most prevalent skin cancer in dogs, primarily attributed to UV radiation exposure. Affected areas typically include regions with sparse hair and pale or depigmented skin. The significance of spontaneous canine cutaneous SCC as a model for its human counterpart is underscored by its resemblance. This study assesses the expression of key markers—Epidermal Growth Factor Receptor (EGFR), Cyclooxygenase-2 (Cox-2), and Ki-67—in canine cutaneous SCC. Our objective is to investigate the association between their expression levels and classical clinicopathological parameters, unraveling the intricate relationships among these molecular markers. In our retrospective analysis of 37 cases, EGFR overexpression manifested in 43.2% of cases, while Cox-2 exhibited overexpression in 97.3%. The EGFR, Cox-2 overexpression, and Ki-67 proliferation indices, estimated through immunohistochemistry, displayed a significant association with the histological grade, but only EGFR labeling is associated with the presence of lymphovascular emboli. The Ki-67 labeling index expression exhibited an association with EGFR and Cox-2. These findings propose that EGFR, Cox-2, and Ki-67 hold promise as valuable markers in canine SCC. EGFR, Cox-2, and Ki-67 may serve as indicators of disease progression, offering insights into the malignancy of a lesion. The implications extend to the potential therapeutic targeting of EGFR and Cox-2 in managing canine SCC. Further exploration of these insights is warranted due to their translational relevance and the development of targeted interventions in the context of canine SCC.

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Innate Lymphoid Cells: New Targets for Cutaneous Squamous Cell Carcinoma Immunotherapy

Cited by 3 publications

References 14 publications

Transcriptomic Study on Human Skin Samples: Identification of Two Subclasses of Actinic Keratoses

Transcriptomic Study on Human Skin Samples: Identification of Two Subclasses of Actinic Keratoses

Natural Killer Cell Recognition and Control of Epithelial Cancers

Immunohistochemical Expression Levels of Epidermal Growth Factor Receptor, Cyclooxygenase-2, and Ki-67 in Canine Cutaneous Squamous Cell Carcinomas

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