Innate lymphoid cells are present in gingivitis and periodontitis

Kindstedt, Elin; Holm, Cecilia; Palmqvist, Py; Sjöström, Mats; Lejon, Kristina; Lundberg, Pernilla

doi:10.1002/jper.17-0750

Cited by 18 publications

(25 citation statements)

References 46 publications

(97 reference statements)

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“…Previous studies have shown that all ILCs subset are present in periodontal tissues from both gingivitis and periodontitis patients (20,21). One study found that ILC1s are the major subset with ILC compartment in soft tissue from both gingivitis and periodontitis (21). While the other group showed that ILC2s are the predominant subset in periodontitis (20).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, immune responses in oral barrier need to be tightly controlled to maintain homeostatic balance between tolerance to commensals and immunity to pathogens (18). Oral mucosa harbors all ILC subsets (19)(20)(21). Two recent studies have shown that ILCs are involved in periodontitis (20,21).One shows that all ILC subsets are increased in periodontitis patients, with a marked effect on ILC2s (20).…”

Section: Introductionmentioning

confidence: 99%

“…Oral mucosa harbors all ILC subsets (19)(20)(21). Two recent studies have shown that ILCs are involved in periodontitis (20,21).One shows that all ILC subsets are increased in periodontitis patients, with a marked effect on ILC2s (20). Another study shows ILC1s are the predominant subset with RANKL expression in gingivitis and periodontitis (21).…”

Section: Introductionmentioning

confidence: 99%

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ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients

Liu

Pan

et al. 2021

Front. Immunol.

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Innate lymphoid cells (ILCs) are emerging as important players in inflammatory diseases. The oral mucosal barrier harbors all ILC subsets, but how these cells regulate the immune responses in periodontal ligament tissue during periodontitis remains undefined. Here, we show that total ILCs are markedly increased in periodontal ligament of periodontitis patients compared with healthy controls. Among them, ILC1s and ILC3s, particularly NKp44+ILC3 subset, are the predominant subsets accumulated in the periodontal ligament. Remarkably, ILC1s and ILC3s from periodontitis patients produce more IL-17A and IFN-γ than that from healthy controls. Collectively, our results highlight the role of ILCs in regulating oral immunity and periodontal ligament inflammation and provide insights into targeting ILCs for the treatment of periodontitis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients

Liu

Pan

et al. 2021

Front. Immunol.

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“…Also, reports based on human tissue are available which showed that human periodontitis is associated with increases in each ILCs subtype in particular ILC2s (Qin et al., ) or ILC1s (Dutzan, Konkel, Greenwell‐Wild, & Moutsopoulos, ). In human gingivitis, the ILC compartment consisted mainly of ILC1 and ILC3 NCR−, although ILC2 and ILC3 NCR+ were also observed (Kindstedt et al., ). Furthermore, RANKL expression was detected on a fraction of the ILC1s suggesting a possible role of ILCs to directly contribute to inflammatory osteolysis (Kindstedt et al., ).…”

Section: Preamblementioning

confidence: 99%

“…In human gingivitis, the ILC compartment consisted mainly of ILC1 and ILC3 NCR−, although ILC2 and ILC3 NCR+ were also observed (Kindstedt et al., ). Furthermore, RANKL expression was detected on a fraction of the ILC1s suggesting a possible role of ILCs to directly contribute to inflammatory osteolysis (Kindstedt et al., ). However, considering that reduction of ILC2s in mice worsened serum‐induced arthritis and collagen‐induced arthritis, and that increasing ILC2 numbers in these models diminished arthritis, ILC2s have anti‐inflammatory functions (Omata et al., ).…”

Section: Preamblementioning

confidence: 99%

Osteoimmunology: Inflammatory osteolysis and regeneration of the alveolar bone

Gruber

2019

J Clinic Periodontology

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Aim Osteoimmunology covers the cellular and molecular mechanisms responsible for inflammatory osteolysis that culminates in the degradation of alveolar bone. Osteoimmunology also focuses on the interplay of immune cells with bone cells during bone remodelling and regeneration. The aim of this review was to provide insights into how osteoimmunology affects alveolar bone health and disease. Method This review is based on a narrative approach to assemble mouse models that provide insights into the cellular and molecular mechanisms causing inflammatory osteolysis and on the impact of immune cells on alveolar bone regeneration. Results Mouse models have revealed the molecular pathways by which microbial and other factors activate immune cells that initiate an inflammatory response. The inflammation‐induced alveolar bone loss occurs with the concomitant suppression of bone formation. Mouse models also showed that immune cells contribute to the resolution of inflammation and bone regeneration, even though studies with a focus on alveolar socket healing are rare. Conclusions Considering that osteoimmunology is evolutionarily conserved, osteolysis removes the cause of inflammation by provoking tooth loss. The impact of immune cells on bone regeneration is presumably a way to reinitiate the developmental mechanisms of intramembranous and endochondral bone formation.

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Innate lymphoid cells: New players in osteoimmunology

Wu,

Lin,

Yuan

et al. 2024

Eur J Immunol

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Innate lymphoid cells (ILCs) are the most recently identified immune cell types existing in lymphoid and nonlymphoid organs. Albeit they lack the expression of antigen receptors, ILCs play vital roles in innate immune responses by producing multiple effector cytokines. The ILC family includes conventional natural killer cells and cytokine‐producing ILCs, which are divided into group 1, group 2, and group 3 ILCs based on their effector cytokines and developmental requirements. Emerging evidence has indicated that ILCs are essential immune regulators of bone homeostasis, playing a critical role in osteoimmunology. In this mini‐review, we discuss recent advances in the understanding of ILC functions in bone homeostasis under physiological and pathological conditions, with an emphasis on the communication between ILCs and bone cells including osteoclasts and osteoblasts, as well as the underlying immunoregulatory networks involving ILC‐derived cytokines and growth factors. This review also discusses future research directions and the potential of targeting ILCs for the treatment of inflammation‐associated bone disorders.

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Innate lymphoid cells are present in gingivitis and periodontitis

Cited by 18 publications

References 46 publications

ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients

ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients

Osteoimmunology: Inflammatory osteolysis and regeneration of the alveolar bone

Innate lymphoid cells: New players in osteoimmunology

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