Innate-like lymphocytes in intestinal infections

Bennett, Michael S.; Round, June L.; Leung, Daniel T.

doi:10.1097/qco.0000000000000189

Cited by 24 publications

(22 citation statements)

References 56 publications

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“…Intraepithelial lymphocytes within the GIT are part of the first line of defense within this large mucosal surface and have been described in eutherians as “innate‐like” lymphocytes (Bennett et al, ). These cells have been described in the GIT of adult opossums (Coutinho et al, ) and koalas and possums (Hemsley et al, ) and were observed in the villi of the phascogale from Day 5 postpartum and could be expected to demonstrate similar protective capacity in the marsupial GIT as in humans.…”

Section: Discussionmentioning

confidence: 99%

Histological Development of the Immune Tissues of a Marsupial, the Red‐Tailed Phascogale (Phascogale calura)

Borthwick

Old

2015

The Anatomical Record

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Red-tailed phascogale (Phascogale calura) pouch young at birth were relatively underdeveloped in comparison with their eutherian counterparts, and the lymphoid tissues of the immune system were found to be histologically immature. The phascogale thymus rapidly developed in the first few days of pouch life and was quickly populated with lymphocytes. By the end of pouch life, involution of the thymus was underway. The bone marrow started to develop in the early stage of pouch life, although adipocytes and megakaryocytes were not observed until slightly later. The liver was hematopoietic from birth and reached histological maturity toward the end of pouch life. The lymph nodes were difficult to detect macroscopically because of their small size, but were easily identified microscopically later in pouch life, particularly in the mesentery, and these lymph nodes exhibited germinal centers by the end of pouch life. The early spleen was predominately mesenchymal, but exhibited some erythropoiesis. Follicles with well-developed germinal centers were not observed until the latest stage of pouch life. Although intraepithelial lymphocytes were detected in the intestines early in pouch life, the discrete lymphoid aggregates and Peyer's patches characteristic of the gut-associated lymphoid tissue (GALT) were not detected until later in pouch life. This is the first report of histological development in phascogale pouch young, as well as the first report of the thymus, bone marrow, and lymph nodes in this dasyurid species at any age. Anat Rec, 299:207-219, 2016. V C 2015 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Histological Development of the Immune Tissues of a Marsupial, the Red‐Tailed Phascogale (Phascogale calura)

Borthwick

Old

2015

The Anatomical Record

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“…The mILL are involved in maintaining gut homeostasis and in early response to intestinal infections ( 4 , 5 ), in autoimmune diseases and cancer ( 6 , 7 ), are able to combat non-self in an MHC-independent fashion ( 8 , 9 ), produce unbiased natural polyreactive antibodies ( 10 , 11 ) and typical cytokine patterns ( 12 , 13 ).…”

Section: Mammalian Innate-like Lymphocytesmentioning

confidence: 99%

“…The main lymphocyte subpopulations displaying innate-like activities in mammals have been identified as γδT cells ( 5 ), mucosa-associated invariant T cells (MAIT) ( 14 ), natural killer T cells (NKT) ( 15 ), B1-B cells ( 16 ), and spleen marginal zone B cells ( 17 ).…”

Section: Mammalian Innate-like Lymphocytesmentioning

confidence: 99%

Fish Lymphocytes: An Evolutionary Equivalent of Mammalian Innate-Like Lymphocytes?

2018

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Lymphocytes are the responsible of adaptive responses, as they are classically described, but evidence shows that subpopulations of mammalian lymphocytes may behave as innate-like cells, engaging non-self rapidly and without antigen presentation. The innate-like lymphocytes of mammals have been mainly identified as γδT cells and B1-B cells, exert their activities principally in mucosal tissues, may be involved in human pathologies and their functions and tissue(s) of origin are not fully understood. Due to similarities in the morphology and immunobiology of immune system between fish and mammals, and to the uniqueness of having free-living larval stages where the development can be precisely monitored and engineered, teleost fish are proposed as an experimental model to investigate human immunity. However, the homology between fish lymphocytes and mammalian innate-like lymphocytes is an issue poorly considered in comparative immunology. Increasing experimental evidence suggests that fish lymphocytes could have developmental, morphological, and functional features in common with innate-like lymphocytes of mammals. Despite such similarities, information on possible links between conventional fish lymphocytes and mammalian innate-like lymphocytes is missing. The aim of this review is to summarize and describe available findings about the similarities between fish lymphocytes and mammalian innate-like lymphocytes, supporting the hypothesis that mammalian γδT cells and B1-B cells could be evolutionarily related to fish lymphocytes.

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“…Interestingly, at the same time, pathologists in Japan saw a very similar condition that affected the stomach, which they termed lymphomatoid gastropathy (132). The etiology of this condition is unknown, although we suspect it is an unusual response to an unknown antigenic stimulus (133). The condition can affect the entire gastrointestinal tract.…”

Section: Natural Killer Cell Enteropathymentioning

confidence: 99%

The Microscope as a Tool for Disease Discovery—A Personal Voyage

Jaffe

2017

Annu. Rev. Pathol. Mech. Dis.

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This review reflects the trajectory of my career in hematopathology, and my personal reflections on scientific advances in the field. During the course of more than 40 years, the approach to classification of hematological malignancies has evolved from descriptive approaches, based on either cytological or clinical features, to a modern approach, which incorporates cutting-edge technologies. My philosophy has focused on defining individual diseases, an approach that can best lead to an understanding of molecular pathogenesis. To quote Carolus Linnaeus (1, p. 19), the father of taxonomy, "The first step in wisdom is to know the things themselves; this notion consists in having a true idea of the objects; objects are distinguished and known by classifying them methodically and giving them appropriate names. Therefore, classification and name-giving will be the foundation of our science."

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Innate-like lymphocytes in intestinal infections

Cited by 24 publications

References 56 publications

Histological Development of the Immune Tissues of a Marsupial, the Red‐Tailed Phascogale (Phascogale calura)

Histological Development of the Immune Tissues of a Marsupial, the Red‐Tailed Phascogale (Phascogale calura)

Fish Lymphocytes: An Evolutionary Equivalent of Mammalian Innate-Like Lymphocytes?

The Microscope as a Tool for Disease Discovery—A Personal Voyage

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