Innate immunity in diabetic nephropathy: Pathogenic mechanisms and therapeutic targets
Le‐Xin Chen,
Shu‐Ru Lu,
Zhi‐Hao Wu
et al.
Abstract:Diabetic nephropathy (DN) represents a prevalent chronic microvascular complication of diabetes mellitus (DM) and is a major cause of end‐stage renal disease. The anfractuous surrounding of DN pathogenesis and the intricate nature of this metabolic disorder often pose challenges in both the diagnosis and treatment of DN compared to other kidney diseases. Hyperglycaemia in DM predispose vulnerable renal cells into microenvironmental disequilibrium and thereby results in innate immunocytes infiltration including… Show more
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