Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies

Ekdahl, Kristina Nilsson; Lambris, John D.; Elwing, Hans; Ricklin, Daniel; Nilsson, Per H.; Teramura, Yuji; Nicholls, Ian A.; Nilsson, Bo

doi:10.1016/j.addr.2011.06.012

Cited by 167 publications

(146 citation statements)

References 105 publications

(109 reference statements)

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“…the hydrophilicity of the superficial layer on the material. A review, published in 2011 dealt with the concept of native immune system response (cascade system) [25]. The article emphasized the importance of the non-denaturation of protein structure at the material/body interface to avoid activation of the primary immune system.…”

Section: Surfaces and Bioadhesionmentioning

confidence: 99%

PNIPAM grafted surfaces through ATRP and RAFT polymerization: Chemistry and bioadhesion

Conzatti

Cavalié

Combes

et al. 2017

Colloids and Surfaces B: Biointerfaces

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a b s t r a c tBiomaterials surface design is critical for the control of materials and biological system interactions. Being regulated by a layer of molecular dimensions, bioadhesion could be effectively tailored by polymer surface grafting. Basically, this surface modification can be controlled by radical polymerization, which is a useful tool for this purpose. The aim of this review is to provide a comprehensive overview of the role of surface characteristics on bioadhesion properties. We place a particular focus on biomaterials functionalized with a brush surface, on presentation of grafting techniques for "grafting to" and "grafting from" strategies and on brush characterization methods. Since atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization are the most frequently used grafting techniques, their main characteristics will be explained. Through the example of poly(N-isopropylacrylamide) (PNIPAM) which is a widely used polymer allowing tuneable cell adhesion, smart surfaces involving PNIPAM will be presented with their main modern applications.

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Section: Surfaces and Bioadhesionmentioning

confidence: 99%

PNIPAM grafted surfaces through ATRP and RAFT polymerization: Chemistry and bioadhesion

Conzatti

Cavalié

Combes

et al. 2017

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

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“…TLRs and nucleotide binding oligomerization domain-like receptors (NODs), particularly NOD2, recognize oxidized products, priming a deleterious cascade of proinflammatory signaling [8]. Inflammation is further worsened by the same blood-dialyzer contact, water impurities, anemia, and antioxidant loss during dialysis [9,10], all of which activate the complement cascade and neutrophil granulocytes. Furthermore, iron administration, which is essential for anemia management, exerts direct mitochondrial toxicity [11], reacting with H 2 O 2 and producing OH and AOPPs [12].…”

Section: Causes Of Increased Inflammation In Esrdmentioning

confidence: 99%

“…The latter phenomenon is linked to leukocyte apoptosis and impaired phagocytosis [37], impaired antigen presentation function [38,39], and increased cytokine production [7]. Dialytic treatment may activate antibodies and complements; indeed, dialyzers absorb albumin, complement component 3 (C3), C1q, immunoglobulin G and ficolin, leading to activation of the alternative [9,40], classical, and lectin [41] pathways of complement. All these alterations in innate immunity unavoidably have affects in adaptive immunity as well, inducing elevated number of high IL-2-producing T-cells [27], low number of B-lymphocytes (due to apoptosis) [42], dysfunctional memory CD4 + T-cells [43], reduced CD4/CD8 ratio, increased Th1/Th2 ratio, and depletion of memory CD4 and CD8 T-cells and regulatory T-cells (Tregs; more likely to exhibit an IL-17 pro-inflammatory phenotype) [44].…”

Section: Adaptive and Innate Immunity Abnormalities In Esrdmentioning

confidence: 99%

Targeting Immunity in End-Stage Renal Disease

2017

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Background: Despite the stable incidence of end-stage renal disease (ESRD), it continues to be associated with an unacceptably high cardiovascular risk. Summary: ESRD is characterized by enhanced oxidative stress and severe inflammation, which boost cardiovascular risk, thus increasing cardiovascular-associated mortality rate. While substantial effort has been made in the technological innovation of dialytic techniques, few significant advances have been made to reduce inflammation in patients with ESRD. Indeed, this contrasts with the extensive scientific breakthroughs made in the basic field of science in targeting inflammation. There is thus a pressing need for clinical trials to test the effect of reducing inflammation in patients with ESRD. Here, we will revisit the negative effect of ESRD on inflammation and explore the impact of enhanced inflammation on cardiovascular outcomes and survival in patients with ESRD. Finally, we will discuss the need for clinical trials that target inflammation in ESRD, as well as weigh potential disadvantages and offer novel innovative approaches. Key Message: We will try to understand why the issue of inflammation has not been successfully addressed thus far in patients with ESRD, while at the same time weighing the potential disadvantages and offering novel innovative approaches for targeting inflammation in patients with ESRD.

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“…If the foreign material cannot be phagocytosed or removed, the acute inflammation persists to initiate ongoing chronic inflammation, thrombotic reaction, foreign body reaction and fibrosis ( Figure 1.4) (Nilsson, Korsgren et al 2010). Among these reactions, biomaterial-associated inflammation has been shown to severely limit the performance of many devices (Selvam, Kundu et al 2011) and initiates many diseases, such as arteriosclerosis, thrombosis, and fibrosis (Ekdahl, Lambris et al 2011). Studies have shown that biomaterial-related inflammation may also promote cancer metastasis ).…”

Section: The Interactions Between Biomaterials and Biological Systemsmentioning

confidence: 99%

“…Figure 1.6 shows the activation of complement system induced by implanted biomaterials, which involves four major steps (Hamad, Al-Hanbali et al 2010, Ekdahl, Lambris et al 2011. The first step is the recognition of non-self materials by three different pathways ( The activation of the complement system may be governed by the adsorbed protein layer around implanted biomaterials.…”

Section: Role Of Complement System In Biomaterial-induced Inflammationmentioning

confidence: 99%

Delivery of therapeutic peptides from thermoplastic polyurethane films

Zhang¹

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Thermoplastic polyurethanes (TPUs) are widely used in biomedical applications due to their excellent mechanical properties and biocompatibility. Their roles as matrices to incorporate therapeutics have been investigated in different areas. With the advance of peptides as therapeutics, there is critical need for investigating delivery of peptides using drug delivery systems. However, there is little work on understanding the release of peptides from TPUs. The aim of this study is to understand how therapeutic peptides might be incorporated and released from TPUs.Initially, we compared the effect of supercritical carbon dioxide treatment and solvent casting on the loading and release of model drugs from polyurethane films. We found that scCO2 treatment may cause a shift of hard segment to the surface of film, but this treatment did not significantly affect physical properties of TPUs. This rearrangement of hard segment caused by scCO2 may affect drug release. We then examined the loading and release of 3 model drugs using scCO2 and compared with solvent casting. ScCO2 was able to load all these 3 model drugs consistently and homogeneously into the films, and the release of these 3 drugs was qualitatively similar by scCO2 or solvent casting.However, the amount of drug accumulated in the films by scCO2 was much less than the total amount of drug in the reaction vessel. This could be a practical limitation for therapeutics such as peptides that are expensive to synthesise. In addition, we found the composition of hard and soft segments may contribute greatly to the efflux of drugs.On the basis of these results, we next investigated the in vitro efflux of peptides from polyurethane films by solvent casting. Interestingly, we found there was a correlation between cumulative release and molecular weight of the peptides. Because one of the causes of implant failure is localised inflammation, we were specifically interested in the delivery of C5aR antagonists from TPU films. First, we found that cyclic peptides may be more stable under harsh casting conditions (elevated temperatures, organic solvents) compared to the linear peptides. Mild conditions are required to retain the bioactivity of peptides. Interestingly, similar to the efflux results of model drugs, the release profiles of peptides were also dependent on the composition of hard and soft segments of TPUs. We also found serum proteins in the medium could facilitate the release of peptides. In addition, in vitro bioactivity of the released peptides was examined by measuring intercellular Ca 2+ concentration mobilization in a cell model of C5a receptor signaling. The ii results demonstrate that released peptides retained their bioactivity. To better control the efflux of peptides, we examined blending of different TPUs. We found that the initial rate and extent of drug released from Tecoflex 80A was significant suppressed by increasing the amount of ElastEon 5325 in the blend. These results offer a simple approach for controlling drug release from TPUs.Furt...

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Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies

Cited by 167 publications

References 105 publications

PNIPAM grafted surfaces through ATRP and RAFT polymerization: Chemistry and bioadhesion

PNIPAM grafted surfaces through ATRP and RAFT polymerization: Chemistry and bioadhesion

Targeting Immunity in End-Stage Renal Disease

Delivery of therapeutic peptides from thermoplastic polyurethane films

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