Innate immune mechanisms linking non-esterified fatty acids and respiratory disease

Wood, Lisa G.; Scott, Hayley A.; Garg, Manohar L.; Gibson, Peter G.

doi:10.1016/j.plipres.2008.10.001

Cited by 61 publications

(59 citation statements)

References 290 publications

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“…Thus, subjects with the highest fat intakes were consuming a proportion of fat that is well above the dietary recommendations of 20-35% energy from fat (US Department of Health and Human Services and US Department of Agriculture, 2005). Various pro-inflammatory mediators increase following a high fat challenge (reviewed in Wood et al, 2009). A number of studies have shown that a meal with fat content ranging from 50-140 g, representing 30-64% total energy, causes oxidative stress and inflammation (Mohanty et al, 2002;Nappo et al, 2002, Aljada et al, 2004Jellema et al, 2004;Blackburn et al, 2006;Patel et al, 2007).…”

Section: Dietary Fat Inflammation and Lung Functionmentioning

confidence: 99%

Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function

et al. 2010

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Background/objectives: Preservation of lung health with aging is an important health issue in the general population, as loss of lung function with aging can lead to the development of obstructive lung disease and is a predictor of all-cause and cardiovascular mortality. Inflammation is increasingly linked to loss of lung function and evidence suggests that consumption of dietary fat exacerbates inflammation. We aimed to determine the association between dietary fat intake and lung function in older people. Subjects/methods: Participants from the Hunter community study, a population-based cohort, were recruited during 2004 and 2005. Participants received a clinical assessment, including spirometry, and provided a blood sample. Diets were analyzed using food-frequency questionnaires. Plasma interleukin (IL)-6 and C-reactive protein was measured by Enzyme-Linked immunosorbent assay. Results: Using backward stepwise linear regression, %energy from dietary fat, age and plasma IL-6 were considered as negative predictors of forced expiratory volume in one second (FEV 1 ) in men. Also in men, %energy intake from dietary fat, age, body mass index and IL-6 were negative predictors of %predicted forced vital capacity (FVC). Smoking and age were negative predictors of FEV 1 /FVC. In women, plasma IL-6 and age were negative predictors of %FVC, whereas obesity was positively associated with FEV 1 /FVC. Conclusions: An increased proportion of fat in the diet is associated with the reduced lung function in older men. Dietary-fat induced innate immune activation and IL-6 release may contribute to this effect. Dietary interventions involving fat restriction should be further investigated as means of preserving lung function with aging.

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Section: Dietary Fat Inflammation and Lung Functionmentioning

confidence: 99%

Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function

et al. 2010

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“…A high-fat diet can also lead to increased systemic inflammation, independent of BMI, due to an increase in circulating fatty acid levels, which activate innate immune responses [9]. Systemic inflammation is evident in asthma, with pro-inflammatory mediators elevated in asthmatics compared with healthy controls [10].…”

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confidence: 99%

Airway inflammation is augmented by obesity and fatty acids in asthma

Scott¹,

Gibson²,

Garg³

et al. 2011

European Respiratory Journal

273

242

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Obesity and asthma are associated, but the mechanism(s) of the association have yet to be elucidated. The aim of this study was to assess airway inflammation in relation to obesity and plasma fatty acids in males and females with and without asthma.Obese (n568) and nonobese (n547) adults with asthma, and obese (n516) and nonobese (n563) healthy controls had induced sputum and venous blood samples analysed for inflammatory markers.There was a positive interaction between obesity and asthma on sputum neutrophil percentage (p50.012) and C-reactive protein level (p50.003). Although sputum eosinophil percentage was elevated in asthma (p50.001), there was no effect of obesity (p50.16). Sputum neutrophil percentage was positively associated with body mass index in females with asthma (b51.015, 95% CI 0.258-1.772; p50.009) and neutrophilic asthma was present in a greater proportion of obese compared with non-obese females (42.9% versus 16.2%; p50.017). In males with asthma, sputum neutrophil percentage was positively associated with total plasma saturated fatty acids (b50.108, 95% CI 0.036-0.180; p50.004) and negatively with monounsaturated fatty acids (b5 -0.068, 95% CI -0.131--0.005; p50.035).This was the first study to demonstrate an increase in neutrophilic airway inflammation in obese asthma. This relationship was significant only in females with asthma. In males, saturated and monounsaturated fatty acids were important predictors of neutrophilic airway inflammation in asthma.

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“…The negative effects may be due to the high levels of free fatty acids (FFAs), which are the primary lipolysis products by lipase [83]. It was reported that excess saturated and n-6 polyunsaturated fatty acids could aggravate the inflammatory response through activating the inflammatory regulator NF-kB in human [84]. Meanwhile, fish fed high levels of n-3 unsaturated fatty acids had lower non-specific immune responses and immune related genes expression of large yellow croaker [85].…”

Section: Interesting Results: High Levels Of Exogenous Lipase Supplemmentioning

confidence: 99%

Impact of exogenous lipase supplementation on growth, intestinal function, mucosal immune and physical barrier, and related signaling molecules mRNA expression of young grass carp (Ctenopharyngodon idella)

Liu

Feng²,

Jiang

et al. 2016

Fish & Shellfish Immunology

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Innate immune mechanisms linking non-esterified fatty acids and respiratory disease

Cited by 61 publications

References 290 publications

Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function

Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function

Airway inflammation is augmented by obesity and fatty acids in asthma

Impact of exogenous lipase supplementation on growth, intestinal function, mucosal immune and physical barrier, and related signaling molecules mRNA expression of young grass carp (Ctenopharyngodon idella)

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