Innate immune genes of the chicken MHC and related regions

Kaufman, Jim

doi:10.1007/s00251-021-01229-2

Cited by 12 publications

(12 citation statements)

References 108 publications

(162 reference statements)

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“…The signal of balancing selection detected in complement component gene C5AR2 contradicts the results of previous findings that report positive selection shaping the diversity of this highly variable innate immunity gene family (Kosiol et al, 2008 ; Webb et al, 2015 ). The complement complex is not only part of the innate immune system, but also a part of the major histocompatibility complex (Kaufman, 2022 ). Therefore, it may also undergo balancing selection typical for the crucial genes in this region (Hedrick, 1998 ).…”

Section: Discussionmentioning

confidence: 99%

Complex patterns shape immune genes diversity during invasion of common raccoon in Europe – Selection in action despite genetic drift

Konopiński

Fijarczyk

Biedrzycka

2022

Evolutionary Applications

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Rapid adaptation is common in invasive populations and is crucial to their long‐term success. The primary target of selection in the invasive species' new range is standing genetic variation. Therefore, genetic drift and natural selection acting on existing variation are key evolutionary processes through which invaders will evolve over a short timescale. In this study, we used the case of the raccoon Procyon lotor invasion in Europe to identify the forces shaping the diversity of immune genes during invasion. The genes involved in the defence against infection should be under intense selection pressure in the invasive range where novel pathogens are expected to occur. To disentangle the selective and demographic processes shaping the adaptive immune diversity of its invasive and expanding populations, we have developed species‐specific single‐nucleotide polymorphism markers located in the coding regions of targeted immune‐related genes. We characterised the genetic diversity of 110 functionally important immune genes in two invasive and one native raccoon genetic clusters, each presenting a different demographic history. Despite the strong effect of demographic processes in the invasive clusters, we detected a subset of genes exhibiting the diversity pattern suggestive of selection. The most likely process shaping the variation in those genes was balancing selection. The selected genes belong to toll‐like receptors and cytokine‐related genes. Our results suggest that the prevalence of selection depends on the level of diversity, that is – less genetically diverse invasive population from the Czech Republic displayed fewer signs of selection. Our results highlight the role of standing genetic variation in adapting to new environment. Understanding the evolutionary mechanisms behind invasion success would enable predicting how populations may respond to environmental change.

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Section: Discussionmentioning

confidence: 99%

Complex patterns shape immune genes diversity during invasion of common raccoon in Europe – Selection in action despite genetic drift

Konopiński

Fijarczyk

Biedrzycka

2022

Evolutionary Applications

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“…Because BLB1 and BLB2 are responsible for producing the MHC class II molecules, they are also vital for activating/initiating adaptive immunity in chicken ( Worley et al, 2008 ; Kaufman, 2021 ). The exon two of both BLB1 and BLB2 contributes to the fabrication of the peptide-binding groove/peptide binding region of the MHC class II molecules.…”

Section: Discussionmentioning

confidence: 99%

“…It possesses classical MHC class I and II genes that produce MHC class I and class II molecules, which are extremely important biological agents in the recognition of foreign pathogenic peptides. It also carries BG family genes and C-type lectin like loci ( Kaufman et al, 1999 ; Shiina et al, 2007 ; Kaufman, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Class I and II genes are extremely important in adaptive immune response, because they are recognized by cytotoxic and helper T lymphocytes, respectively; some are also important in innate immunity (i.e., the BF1 gene, the minor class I gene that corresponds with natural killer cells as ligands). The BG1 gene is also involved in adaptive immune response ( Goto et al, 2009 ; Chen et al, 2018 ; Kaufman, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Application of next-generation sequencing for the high-resolution typing of MHC-B in Korean native chicken

Ediriweera

Manjula²,

Cho³

et al. 2022

Front. Genet.

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The major histocompatibility complex-B (MHC-B) region of chicken is crucially important in their immunogenesis and highly diverse among different breeds, lines, and even populations. Because it determines the resistance/susceptibility to numerous infectious diseases, it is important to analyze this genomic region, particularly classical class I and II genes, to determine the variation and diversity that ultimately affect antigen presentation. This study investigated five lines of indigenous Korean native chicken (KNC) and the Ogye breed using next-generation sequencing (NGS) data with Geneious Prime-based assembly and variant calling with the Genome Analysis Toolkit (GATK) best practices pipeline. The consensus sequences of MHC-B (BG1-BF2) were obtained for each chicken line/breed and their variants were analyzed. All of the Korean native chicken lines possessed an excessive number of variants, including an ample amount of high-impact variants that provided useful information regarding modified major histocompatibility complex molecules. The study confirmed that next-generation sequencing techniques can effectively be used to detect MHC variabilities and the KNC lines are highly diverse for the MHC-B region, suggesting a substantial divergence from red junglefowl.

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“…Avian IS seems to be simpler than mammals. Although both do the same actions, different pathways are sometimes used [19,20].…”

Section: A Brief Overview Of the Avian Immune Systemmentioning

confidence: 99%

From Understanding the Immune Response against Coccidiosis to the Use of Coccidia Vaccines

Gomez-Osorio¹,

Dehaeck²,

Cuello³

et al. 2023

Poultry Farming - New Perspectives and Applications

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Avian coccidiosis is the most costly global poultry parasitic disease, which represents a threat to food production and sustainability. Coccidiosis is still ubiquitous even in modern poultry production systems. Protective immunity against coccidia does develop but differs for each Eimeria species and depends on the method of immunization and the immune response (including both early innate immune response by several proteins and professional phagocytes as well as acquired immune response with specialized cells). In addition, GALT is a master tissue in the immune response against coccidiosis because of its crucial functions: acquired immunity in both the cellular and humoral immune responses. Here, we present an extensive review on the immune response against coccidiosis and the use of vaccines as an alternative for consideration in integrated sustained coccidiosis control programs.

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Innate immune genes of the chicken MHC and related regions

Cited by 12 publications

References 108 publications

Complex patterns shape immune genes diversity during invasion of common raccoon in Europe – Selection in action despite genetic drift

Complex patterns shape immune genes diversity during invasion of common raccoon in Europe – Selection in action despite genetic drift

Application of next-generation sequencing for the high-resolution typing of MHC-B in Korean native chicken

From Understanding the Immune Response against Coccidiosis to the Use of Coccidia Vaccines

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