2020
DOI: 10.1155/2020/5291714
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Abstract: Innate immune effectors constitute the first line of host defense against pathogens. However, the roles of these effectors are not clearly defined during Klebsiella pneumoniae (K. pneumoniae) respiratory infection. In the current study, we established an acute pneumonia model of K. pneumoniae respiratory infection in mice and confirmed that the injury was most severe 48 h post infection. Flow cytometric assay demonstrated that alveolar macrophages were the predominant cells in BALF before infection, and neutro… Show more

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Cited by 9 publications
(13 citation statements)
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References 41 publications
(13 reference statements)
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“…Furthermore, the work showed that CCR2 + monocytes were the main producers of TNF-α in infected mice. Work carried out in mice challenged with clinical isolates of K. pneumoniae also showed increases in the pulmonary levels of TNF-α, IL-1β, IL-6 [32], CXCL1, MCP-1, and MIP-2 [33], as well as neutrophil infiltration in the respiratory tract [32,33].…”
Section: Discussionmentioning
confidence: 93%
See 1 more Smart Citation
“…Furthermore, the work showed that CCR2 + monocytes were the main producers of TNF-α in infected mice. Work carried out in mice challenged with clinical isolates of K. pneumoniae also showed increases in the pulmonary levels of TNF-α, IL-1β, IL-6 [32], CXCL1, MCP-1, and MIP-2 [33], as well as neutrophil infiltration in the respiratory tract [32,33].…”
Section: Discussionmentioning
confidence: 93%
“…On the other hand, studies carried out in immunocompetent mice infected with the clinical isolates K. pneumoniae KPC+ or OXA-48+ showed that doses of 10 7 CFUs or higher are necessary to achieve a respiratory infection that reaches densities of 6-7 log 10 CFUs/g lung [31]. Similarly, doses of 10 8 CFUs were required to achieve respiratory infections in adult C57BL/6 [32] and BALB/c [33] mice with clinical isolates of K. pneumoniae. Consistent with these studies, doses of 10 7 CFUs or higher of LABACER 01 or LABACER 27 were required in this study to achieve respiratory infection in adult immunocompetent BALB/c mice.…”
Section: Discussionmentioning
confidence: 99%
“…Clinical strains of A. baumannii SJZ24, SJZ26, and SJZ09 were isolated from Bethune International Peace Hospital in Shijiazhuang, China, in 2016 ( Zeng et al, 2019 ). P. aeruginosa strain XN-1 ( Gao et al, 2020 ), K. pneumoniae strain YBQ ( Liu et al, 2020 ), and S. pneumoniae were isolated from Chongqing Southwest Hospital. S. aureus strain KM-22 was isolated from the Second Affiliated Hospital of Kunming Medical University ( Zeng et al, 2020 ).…”
Section: Methodsmentioning
confidence: 99%
“…A string test indicated that YBQ exhibits a hypermucoviscous phenotype ( 7 ). Animal challenge studies indicate that YBQ is a strain with high virulence ( 8 ). Here, we report the complete genome sequence of YBQ, which may be essential for further study of the virulence and pathogenic mechanism of this isolate.…”
Section: Announcementmentioning
confidence: 99%