Innate defences against viraemia

A Novel Serum Protein That Is Selectively Produced by Cytotoxic Lymphocytes

“…Thus, at present, it seems unlikely that Ksp37 functions as a modulator of cytotoxicity or as a cytotoxic effector molecule by itself. Cytotoxic lymphocytes produce various kinds of antimicrobial molecules such as IFN-␥ and granulysin (55), and human serum has been reported to possess nonspecific antiviral activity (56). However, Ksp37 had no effect on the growth of E. coli and on the in vitro infectivity of polioviruses, coxsackieviruses, echoviruses, adenoviruses, and herpes simplex viruses (our unpublished data).…”

A Novel Serum Protein That Is Selectively Produced by Cytotoxic Lymphocytes

“…Thus, at present, it seems unlikely that Ksp37 functions as a modulator of cytotoxicity or as a cytotoxic effector molecule by itself. Cytotoxic lymphocytes produce various kinds of antimicrobial molecules such as IFN-␥ and granulysin (55), and human serum has been reported to possess nonspecific antiviral activity (56). However, Ksp37 had no effect on the growth of E. coli and on the in vitro infectivity of polioviruses, coxsackieviruses, echoviruses, adenoviruses, and herpes simplex viruses (our unpublished data).…”

Antiinflammatory Properties of HDL

“…18 HDLs account for a significant component of the antiviral activity of human plasma. 61 Van Lenten et al 62 reported that HDLs lose their antiinflammatory properties during acute influenza infection. HDLs isolated from mice infected with influenza A virus lose their ability to protect LDLs against oxidation by human artery wall cells and are ineffective in preventing the LDL-induced monocyte chemotactic activity in a human artery wall coculture.…”

NK and NKT Cell-Independent Contribution of Interleukin-15 to Innate Protection against Mucosal Viral Infection

“…Indeed, as we and others (3,21,22,32,33) have shown, the activation of innate immunity following local delivery of Toll-like receptor (TLR) ligands, such as unmethylated CpGcontaining DNA, to the vaginal mucosa can protect female mice against genital infection with herpes simplex virus type 2 (HSV-2). Numerous factors are involved in the innate immune defense, but NK and NKT cells and interleukin-15 (IL-15) are of particular interest since they can rapidly respond to viral pathogens (8,11,12,19,20,29,35). We recently demonstrated that IL-15 and NK and NKT cells are critical for innate protection against intravaginal (IVAG) HSV-2 infections (4).…”

A Novel Serum Protein That Is Selectively Produced by Cytotoxic Lymphocytes

“…Thus, at present, it seems unlikely that Ksp37 functions as a modulator of cytotoxicity or as a cytotoxic effector molecule by itself. Cytotoxic lymphocytes produce various kinds of antimicrobial molecules such as IFN-␥ and granulysin (55), and human serum has been reported to possess nonspecific antiviral activity (56). However, Ksp37 had no effect on the growth of E. coli and on the in vitro infectivity of polioviruses, coxsackieviruses, echoviruses, adenoviruses, and herpes simplex viruses (our unpublished data).…”

Antiinflammatory Properties of HDL

“…18 HDLs account for a significant component of the antiviral activity of human plasma. 61 Van Lenten et al 62 reported that HDLs lose their antiinflammatory properties during acute influenza infection. HDLs isolated from mice infected with influenza A virus lose their ability to protect LDLs against oxidation by human artery wall cells and are ineffective in preventing the LDL-induced monocyte chemotactic activity in a human artery wall coculture.…”

NK and NKT Cell-Independent Contribution of Interleukin-15 to Innate Protection against Mucosal Viral Infection

“…Indeed, as we and others (3,21,22,32,33) have shown, the activation of innate immunity following local delivery of Toll-like receptor (TLR) ligands, such as unmethylated CpGcontaining DNA, to the vaginal mucosa can protect female mice against genital infection with herpes simplex virus type 2 (HSV-2). Numerous factors are involved in the innate immune defense, but NK and NKT cells and interleukin-15 (IL-15) are of particular interest since they can rapidly respond to viral pathogens (8,11,12,19,20,29,35). We recently demonstrated that IL-15 and NK and NKT cells are critical for innate protection against intravaginal (IVAG) HSV-2 infections (4).…”

A Novel Serum Protein That Is Selectively Produced by Cytotoxic Lymphocytes

“…Thus, at present, it seems unlikely that Ksp37 functions as a modulator of cytotoxicity or as a cytotoxic effector molecule by itself. Cytotoxic lymphocytes produce various kinds of antimicrobial molecules such as IFN-␥ and granulysin (55), and human serum has been reported to possess nonspecific antiviral activity (56). However, Ksp37 had no effect on the growth of E. coli and on the in vitro infectivity of polioviruses, coxsackieviruses, echoviruses, adenoviruses, and herpes simplex viruses (our unpublished data).…”

Antiinflammatory Properties of HDL

“…18 HDLs account for a significant component of the antiviral activity of human plasma. 61 Van Lenten et al 62 reported that HDLs lose their antiinflammatory properties during acute influenza infection. HDLs isolated from mice infected with influenza A virus lose their ability to protect LDLs against oxidation by human artery wall cells and are ineffective in preventing the LDL-induced monocyte chemotactic activity in a human artery wall coculture.…”

NK and NKT Cell-Independent Contribution of Interleukin-15 to Innate Protection against Mucosal Viral Infection

“…Indeed, as we and others (3,21,22,32,33) have shown, the activation of innate immunity following local delivery of Toll-like receptor (TLR) ligands, such as unmethylated CpGcontaining DNA, to the vaginal mucosa can protect female mice against genital infection with herpes simplex virus type 2 (HSV-2). Numerous factors are involved in the innate immune defense, but NK and NKT cells and interleukin-15 (IL-15) are of particular interest since they can rapidly respond to viral pathogens (8,11,12,19,20,29,35). We recently demonstrated that IL-15 and NK and NKT cells are critical for innate protection against intravaginal (IVAG) HSV-2 infections (4).…”