2000
DOI: 10.1002/1099-1654(200011/12)10:6<395::aid-rmv298>3.0.co;2-v
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Innate defences against viraemia

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Cited by 9 publications
(4 citation statements)
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“…Thus, at present, it seems unlikely that Ksp37 functions as a modulator of cytotoxicity or as a cytotoxic effector molecule by itself. Cytotoxic lymphocytes produce various kinds of antimicrobial molecules such as IFN-␥ and granulysin (55), and human serum has been reported to possess nonspecific antiviral activity (56). However, Ksp37 had no effect on the growth of E. coli and on the in vitro infectivity of polioviruses, coxsackieviruses, echoviruses, adenoviruses, and herpes simplex viruses (our unpublished data).…”
Section: Discussionmentioning
confidence: 99%
“…Thus, at present, it seems unlikely that Ksp37 functions as a modulator of cytotoxicity or as a cytotoxic effector molecule by itself. Cytotoxic lymphocytes produce various kinds of antimicrobial molecules such as IFN-␥ and granulysin (55), and human serum has been reported to possess nonspecific antiviral activity (56). However, Ksp37 had no effect on the growth of E. coli and on the in vitro infectivity of polioviruses, coxsackieviruses, echoviruses, adenoviruses, and herpes simplex viruses (our unpublished data).…”
Section: Discussionmentioning
confidence: 99%
“…18 HDLs account for a significant component of the antiviral activity of human plasma. 61 Van Lenten et al 62 reported that HDLs lose their antiinflammatory properties during acute influenza infection. HDLs isolated from mice infected with influenza A virus lose their ability to protect LDLs against oxidation by human artery wall cells and are ineffective in preventing the LDL-induced monocyte chemotactic activity in a human artery wall coculture.…”
Section: Antioxidant Properties Of Hdlmentioning
confidence: 99%
“…Two naturally occurring nonspecific broad-spectrum antiviral agents, University of Texas Inhibitor glycoprotein and high-density lipoprotein, have been identified in human serum [22][23][24]. In addition, certain saturated medium-chain and unsaturated long-chain fatty acids and their corresponding monoglycerides inactivate HSV and other enveloped viruses rapidly after contact [25][26][27].…”
Section: Vzv Orf32mentioning
confidence: 99%
“…VZV DNA can also be detected in plasma and all subpopulations of PBMCs (CD4 þ T, CD8 þ T, and B lymphocytes and monocytes/macrophages) obtained from children with varicella [15]. Of note, cell-associated VZV virions are not affected by the presence of non-specific antiviral substances in the serum [22][23][24][25][26][27]. The virus hematogenously reaches various organs, including the reticuloendothelial system of the liver and spleen, where VZV drastically replicates, bringing about secondary viremia.…”
Section: Tissue Tropism Of Vzvmentioning
confidence: 99%