Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens

Netea, Mihai G.; Schlitzer, Andreas; Placek, Katarzyna; Joosten, Leo A. B.; Schultze, Joachim L.

doi:10.1016/j.chom.2018.12.006

Cited by 371 publications

(340 citation statements)

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“…Co-treatment with a nanoimmunotherapeutic agent that prevents CD40-CD40L co-stimulation 186 led to the induction of tolerance. these observations highlight that the innate and adaptive immune systems work in conjunction, and that immune memory can be best considered a feature relevant to phagocytes and lymphocytes 187 .…”

Section: Published Online XX Xx Xxxxmentioning

confidence: 88%

Defining trained immunity and its role in health and disease

et al. 2020

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| Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed 'trained immunity', a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define 'trained immunity' as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity. ✉

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Section: Published Online XX Xx Xxxxmentioning

confidence: 88%

Defining trained immunity and its role in health and disease

et al. 2020

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“…Infection-specific cues influence macrophage phenotypes through "trained immunity" (20). The type, dose, and duration of microbial stimuli can guide monocytes and macrophages toward new antiinflammatory, proinflammatory, or other more complex phenotypes (21).…”

Section: Introductionmentioning

confidence: 99%

Pneumonia recovery reprograms the alveolar macrophage pool

et al. 2020

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“…14 BCG has been proved to provide nonspecific protection of mice against influenza virus infection probably by the induction of trained immunity. 14 Most, if not all, of the infants received regular immunizations, including BCG, in China and other Asian countries, and it is well known that influenza can cause more ARDS in the adults, yet very less in children.…”

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confidence: 99%