Inmunosenescencia: pruebas cutáneas de hipersensibilidad retardada en adultos mayores chilenos autovalentes

Blackburn, Tim; Mur, R. Paola; Jofré, Anna; Coll, Carlos; Jurlow, M. Elizabeth

doi:10.4067/s0034-98872000000400003

Cited by 2 publications

(1 citation statement)

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“…The third domain is the barrier of acquired immunity, which has age-related reduced hematopoiesis of naïve lymphocytes [8]. Furthermore, functional changes related to skin immunosenescence include reduced delayed skin hypersensitivity [10]. This reduction is plausibly linked to an aging-related maturative inhibition of dendritic cells and a functional decline in Th1 immunity.…”

Section: Skin Immunosenescence: Structural and Functional Hallmarksmentioning

confidence: 99%

Immunosenescence and Skin: A State of Art of Its Etiopathogenetic Role and Crucial Watershed for Systemic Implications

Papa

Pomi

Borgia

et al. 2023

IJMS

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Immunosenescence is a complex multifactorial phenomenon consisting of wide-ranging remodeling of the immune system during the life span, resulting in an age-related qualitative–quantitative decline of immune cells and cytokines. A growing body of evidence in the international literature is highlighting the etiopathogenetic role of skin immunosenescence in the onset of various dermatologic conditions. Skin immunosenescence also serves as an interesting watershed for the onset of system-wide conditions in the context of allergic inflammation. Moreover, in recent years, an increasingly emerging and fascinating etiopathogenetic parallelism has been observed between some mechanisms of immunosenescence, both at cutaneous and systemic sites. This would help to explain the occurrence of apparently unconnected comorbidities. Throughout our review, we aim to shed light on emerging immunosenescent mechanisms shared between dermatologic disorders and other organ-specific diseases in the context of a more extensive discussion on the etiopathogenetic role of skin immunosenescence. A promising future perspective would be to focus on better understanding the mutual influence between skin and host immunity, as well as the influence of high inter-individual variability on immunosenescence/inflammaging. This can lead to a more comprehensive “immunobiographic” definition of each individual.

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Section: Skin Immunosenescence: Structural and Functional Hallmarksmentioning

confidence: 99%