Inmunoglobulina G intravenosa como tratamiento adyuvante en epilepsia infantil farmacorresistente

Gonzalez-Castillo, Zurisadai; Gómez, Elsa Solórzano; Gómez, Armando Torres; Sobero, J.A. Venta; Moctezuma, Juvenal Gutiérrez

doi:10.1016/j.nrl.2017.09.005

Neurología

2020

DOI: 10.1016/j.nrl.2017.09.005

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Inmunoglobulina G intravenosa como tratamiento adyuvante en epilepsia infantil farmacorresistente

Zurisadai Gonzalez-Castillo

Elsa Solórzano Gómez

Armando Torres Gómez

et al.

Abstract: According to the results of this study, intravenous immunoglobulin may be an effective therapy for reducing the frequency and duration of seizures in paediatric patients with drug-resistant epilepsy.

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Expression Profile of Immunoglobulin G Glycosylation in Children With Epilepsy in Han Nationality

Shi²,

Wang³

et al. 2022

Front. Mol. Neurosci.

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BackgroundEpilepsy is a chronic brain disease that recurs during childhood, and more than half of adult epilepsy originates from childhood. Studies suggested that immunoglobulin G (IgG) glycosylation are closely related to neurological diseases. Here we analyzed the characteristics of the immunoglobulin glycosylation profile of children with epilepsy.MethodsPatients were recruited in Taian, Shandong Province from December 2019 to March 2020. Serum IgG glycome composition was analyzed by hydrophilic interaction liquid chromatography with ultra-high-performance liquid chromatography approach.ResultsThe proportion of fucosylated glycans in total IgG glycans was 93.72% in the epilepsy patients, which was significantly lower than that in the control group (94.94%). A lower level of total monogalactosylated and digalactosylated glycans were observed in the epilepsy patients group (30.76 and 40.14%) than that in the controls (36.17 and 42.69%). There was no significant difference between the two groups in bisected GlcNAc glycans and sialylated glycans.ConclusionThe decrease of core fucosylation and galactosylation may promote the inflammatory reaction of the body and participate in the occurrence of epilepsy in children.

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Expression Profile of Immunoglobulin G Glycosylation in Children With Epilepsy in Han Nationality

Shi²,

Wang³

et al. 2022

Front. Mol. Neurosci.

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show abstract

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Inmunoglobulina G intravenosa como tratamiento adyuvante en epilepsia infantil farmacorresistente

Abstract: According to the results of this study, intravenous immunoglobulin may be an effective therapy for reducing the frequency and duration of seizures in paediatric patients with drug-resistant epilepsy.

Cited by 1 publication

References 21 publications

Expression Profile of Immunoglobulin G Glycosylation in Children With Epilepsy in Han Nationality

Expression Profile of Immunoglobulin G Glycosylation in Children With Epilepsy in Han Nationality

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