Inland Water Survey in Great Britain

Cunningham, Brysson

doi:10.1038/1401106a0

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“…The plaque-forming cells (PFC) were counted by the method of Cunningham [5]. Table 1 shows the high immunogenicity of both fraction 1 and the lysate.…”

Section: Methodsmentioning

confidence: 99%

Antigenic properties of a water soluble fraction of sheep erythrocytes

1972

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Soluble antigen of sheep erythrocytes 387average potential life-span of B cells is of the order of 8 weeks and of T cells 16 weeks. If the life-span of T and B cells is different, it might be asked why the increase in percent labeling of CBA small TDL was linear (Fig. 3), implying the presence of only one cell population homogeneous with respect t o lifespan. The explanation probably lies in the fact that B cells comprise only about 15 % of the normal TDL population studied. Hence, since the difference in life-span of the two cell types is not dramatic, it is unlikely t o be detected by measures which screen the total TDL pool. Studies on immunological memory to a protein antigen have demonstrated that B cells primed t o that antigen are present in thoracic duct lymph for months after priming [ 101. The present findings that some B cells recirculate, albeit more slowly than T cells, and have a relatively long life-span, suggest that memory B cells may form part of the recirculating pool. We would like to acknoledge the assistance of Dr. A . Rasten in the studies involving the use of radioiodinated immune complexes.A technique for preparing soluble extracts of sheep erythrocytes is described. A fraction thereof is fully immunogenic and inhibits antibody formed by spleen cells from only those mice immunized with sheep red blood cells, but not from those which received extracts of horse red blood cells.The specificity of this fraction varies from one sheep to another.

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“…The plaque-forming cells (PFC) were counted by the method of Cunningham [5]. Table 1 shows the high immunogenicity of both fraction 1 and the lysate.…”

Section: Methodsmentioning

confidence: 99%