Inkjet-Printed Silver Electrode Array for in-vivo Electrocorticography

Donaldson, Preston D.; Ghanbari, Leila; Rynes, Mathew L.; Kodandaramaiah, Suhasa B.; Swisher, Sarah L.

doi:10.1109/ner.2019.8717083

Cited by 6 publications

(8 citation statements)

References 13 publications

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“…Further, the digital design methodology of the See-Shell could be used to develop polymer skulls with an expanded FOV to encompass the cerebellar cortex or more lateral regions of the cortex. Finally, future Mesoscopes could be designed to incorporate miniaturized amplifiers for integrating chronically implanted recording electrodes for simultaneous mesoscale imaging and deep brain neural recordings, or to interface with electrodes incorporated in the See-Shells for electrocorticography (ECoG) 58 . Wiring: A single coax cable was used to connect the CMOS sensor to the main DAQ board.…”

Section: Discussionmentioning

confidence: 99%

Miniaturized head-mounted device for whole cortex mesoscale imaging in freely behaving mice

Rynes

Surinach

Linn

et al. 2020

Preprint

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The advent of genetically encoded calcium indicators, along with surgical preparations such as thinned skulls or refractive index matched skulls, have enabled mesoscale cortical activity imaging in head-fixed mice. Such imaging studies have revealed complex patterns of coordinated activity across the cortex during spontaneous behaviors, goal-directed behavior, locomotion, motor learning, and perceptual decision making. However, neural activity during unrestrained behavior significantly differs from neural activity in head-fixed animals. Whole-cortex imaging in freely behaving mice will enable the study of neural activity in a larger, more complex repertoire of behaviors not possible in head-fixed animals. Here we present the “Mesoscope,” a wide-field miniaturized, head-mounted fluorescence microscope compatible with transparent polymer skulls recently developed by our group. With a field of view of 8 mm x 10 mm and weighing less than 4 g, the Mesoscope can image most of the mouse dorsal cortex with resolution ranging from 39 to 56 µm. Stroboscopic illumination with blue and green LEDs allows for the measurement of both fluorescence changes due to calcium activity and reflectance signals to capture hemodynamic changes. We have used the Mesoscope to successfully record mesoscale calcium activity across the dorsal cortex during sensory-evoked stimuli, open field behaviors, and social interactions. Finally, combining the mesoscale imaging with electrophysiology enabled us to measure dynamics in extracellular glutamate release in the cortex during the transition from wakefulness to natural sleep.

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Section: Discussionmentioning

confidence: 99%

Miniaturized head-mounted device for whole cortex mesoscale imaging in freely behaving mice

Rynes

Surinach

Linn

et al. 2020

Preprint

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“…1a) and exposed electrode pads with an average diameter of ~ 300 µm for interfacing the brain. Once the electrode arrays were fabricated, they were integrated into a 3D printed frame adapted from our previous work [9], [26], [27]. The PCB interface was bonded to the ECoG array using conductive epoxy (S. Fig.…”

Section: Desktop Fabricated Flexible Graphene Ecog Electrodesmentioning

confidence: 99%

“…Further, most neuroscience laboratories require rapid and flexible design alterations to adapt to various experimental contexts, which is hard to achieve in traditional microfabrication procedures. To simplify the fabrication procedure, inkjet printing conductive materials such as silver nanoparticle inks [9] and conductive polymers like PEDOT:PSS [10] has been used to create flexible and reconfigurable ECoG electrode arrays. Currently, these approaches require expensive printers and still rely on specialized or microfabrication techniques to insulate the electrode [11].…”

Section: Introductionmentioning

confidence: 99%

Fully Desktop Fabricated Flexible Graphene Electrocorticography (ECoG) Arrays

Hossain

Navabi

et al. 2022

Preprint

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Flexible Electrocorticography (ECoG) electrode arrays that conform to the cortical surface and record surface field potentials from multiple brain regions provide unique insights into how computations occurring in distributed brain regions mediate behavior. Current flexible ECoG devices require highly specialized microfabrication methods, precluding the ability to fabricate customizable and low-cost flexible ECoG devices easily. Here we present a fully desktop fabricated flexible graphene ECoG array. First, we synthesized a stable, conductive ink via liquid exfoliation of Graphene in Cyrene. Next, we have established a stencil-printing process for patterning the graphene ink via laser-cut stencils on flexible polyimide substrates. Benchtop tests indicate that the graphene electrodes have good conductivity of ~ 1.1 x 103 S.cm-1, flexibility to maintain their electrical connection under static bending, and electrochemical stability in a 15-day accelerated corrosion test. Chronically implanted graphene ECoG devices remain fully functional for up to 180 days, with average in vivo impedances of 24.72 ± 95.23 kΩ at 1 kHz. The ECoG device can measure spontaneous surface field potentials from mice under awake and anesthetized states and sensory stimulus-evoked responses. The stencil-printing fabrication process can be used to create Graphene ECoG devices with customized electrode layouts within 24 hours using commonly available laboratory equipment.

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“…The most representative mask-less microfabrication process is printing technology. Printing-based low-cost, high throughput, and large-area microelectronic devices with the capability of mask-less additive micromanufacturing have been developed over the last two decades. , Among various printing technologies, drop-on-demand inkjet printing showed excellence in micropatterning various organic or inorganic electrode materials on flexible substrates at low temperatures for biomedical applications. , Owing to the possibility of thousands of multinozzle inkjet printing for parallel microfabrication processing, we can fabricate high-resolution patterns with high throughput over large areas. , Moreover, inkjet printing has been integrated into a roll-to-roll printing scheme for continuous high-throughput fabrication, and the possibility of even integrating the conventional thin-film vacuum deposition into the roll-to-roll process has been demonstrated for taking advantage of well-studied vacuum deposited thin film materials. − However, inkjet printing of transparent electrode materials for the aforementioned applications has been challenging either due to the high annealing temperature of the transparent electrode materials or due to the high cost and complexity of the fabrication processes. For example, wide-bandgap metal oxide conductive sol–gel ink materials such as indium tin oxide (ITO) or antimony-doped tin oxide (ATO) have been proposed as printed transparent electrodes .…”

Section: Introductionmentioning

confidence: 99%

“…15,16 Among various printing technologies, drop-on-demand inkjet printing showed ex- cellence in micropatterning various organic or inorganic electrode materials on flexible substrates at low temperatures for biomedical applications. 17,18 Owing to the possibility of thousands of multinozzle inkjet printing for parallel microfabrication processing, we can fabricate high-resolution patterns with high throughput over large areas. 19,20 Moreover, inkjet printing has been integrated into a roll-to-roll printing scheme for continuous high-throughput fabrication, and the possibility of even integrating the conventional thin-film vacuum deposition into the roll-to-roll process has been demonstrated for taking advantage of well-studied vacuum deposited thin film materials.…”

Section: ■ Introductionmentioning

confidence: 99%

Inkjet-Printed Polyelectrolyte Seed Layer-Based, Customizable, Transparent, Ultrathin Gold Electrodes and Facile Implementation of Photothermal Effect

Kim

Hong

et al. 2023

ACS Appl. Mater. Interfaces

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Recently, interest in transparent electrodes has been increasing in biomedical engineering applications for such as electro-optical hybrid neuro-technologies. However, conventional photolithography-based electrode fabrication methods have limited design customization and large-area applicability. For biomedical engineering applications, it is crucial that we can easily customize the electrode design for different patients over a large body area. In this paper, we propose a novel method to fabricate customization-friendly, transparent, ultrathin, gold microelectrodes using inkjet printing technology. Unlike with typical direct printing of conductive inks, we inkjet-printed a polymer nucleation-inducing seed layer, followed by mask-less vacuum deposition of ultrathin gold (<6 nm) to produce selectively, high-transparency electrodes in the predefined shapes of the inkjet-printed polymer. Owing to the design flexibility of inkjet printing, the transparent ultrathin gold electrodes can be highly efficient in design customization over a large area. Simultaneously, a layer of nonconductive gold islands is formed in the nonprinted region, and this nanostructured layer can implement a photothermal effect that offers versatility for novel biomedical applications. As a demonstration of the effectiveness of these transparent electrodes, and the facile implementation of the photothermal effect for biomedical applications, we successfully fabricated transparent resistive temperature detectors. We used these to directly sense the photothermal effect and to demonstrate their bioimaging capabilities.

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Inkjet-Printed Silver Electrode Array for in-vivo Electrocorticography

Cited by 6 publications

References 13 publications

Miniaturized head-mounted device for whole cortex mesoscale imaging in freely behaving mice

Miniaturized head-mounted device for whole cortex mesoscale imaging in freely behaving mice

Fully Desktop Fabricated Flexible Graphene Electrocorticography (ECoG) Arrays

Inkjet-Printed Polyelectrolyte Seed Layer-Based, Customizable, Transparent, Ultrathin Gold Electrodes and Facile Implementation of Photothermal Effect

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