Inkjet drug printing onto contact lenses: Deposition optimisation and non-destructive dose verification

Pollard, Thomas D.; Seoane-Viaño, Iria; Ong, Jun Jie; Januskaite, Patricija; Awwad, Sahar; Orlu, Mine; Bande, Manuel Febrero; Basit, Abdul W.; Goyanes, Álvaro

doi:10.1016/j.ijpx.2022.100150

Cited by 11 publications

(21 citation statements)

References 76 publications

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“…[ 6 ] Additionally, IJP offers great flexibility in terms of substrate, as formulated inks can be printed onto a wide variety of materials, including films, microneedles (MNs), clinical stents, contact lenses, and even nails. [ 7–11 ] This demonstrates the versatility of this technique in developing unique pharmaceutical forms and drug‐loaded medical devices.…”

Section: Introductionmentioning

confidence: 92%

“…The pharma-ink should be carefully designed to achieve the desired drug concentration, viscosity, surface tension, and other rheological properties. [11,56] These properties significantly impact the printing performance, including droplet formation, ejection, and deposition accuracy. Optimizing the pharma-ink involves selecting appropriate excipients, solvents, and drug carriers to ensure ink stability, compatibility, and suitability for the printing system.…”

Section: Unlocking Precision: Optimizing Ijp Parameters For Personali...mentioning

confidence: 99%

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Inkjet Printing of Pharmaceuticals

Carou‐Senra,

Rodríguez‐Pombo,

Awad

et al. 2023

Advanced Materials

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Inkjet printing (IJP) is an additive manufacturing process that selectively deposits ink materials, layer‐by‐layer, to create three‐dimensional (3D) objects or two‐dimensional (2D) patterns with precise control over their structure and composition. This technology has emerged as an attractive and versatile approach to address the ever‐evolving demands of personalized medicine in the healthcare industry. Although originally developed for non‐healthcare applications, IJP harnesses the potential of pharma‐inks, which are meticulously formulated inks containing drugs and pharmaceutical excipients. Delving into the formulation and components of pharma‐inks, the key to precise and adaptable material deposition enabled by IJP is unraveled. The review extends its focus to substrate materials, including paper, films, foams, lenses, and 3D‐printed materials, showcasing their diverse advantages, whilst exploring a wide spectrum of therapeutic applications. Additionally, the potential benefits of hardware and software improvements, along with artificial intelligence integration, are discussed to enhance IJP's precision and efficiency. Embracing these advancements, IJP holds immense potential to reshape traditional medicine manufacturing processes, ushering in the era of medical precision. However, further exploration and optimization are needed to fully utilize IJP's healthcare capabilities. As researchers push the boundaries of IJP, the vision of patient‐specific treatment is on the horizon of becoming a tangible reality.This article is protected by copyright. All rights reserved

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Section: Introductionmentioning

confidence: 92%

Section: Unlocking Precision: Optimizing Ijp Parameters For Personali...mentioning

confidence: 99%

Inkjet Printing of Pharmaceuticals

Carou‐Senra,

Rodríguez‐Pombo,

Awad

et al. 2023

Advanced Materials

Self Cite

View full text Add to dashboard Cite

show abstract

“…Direct printing and inkjet printing are two popular printing methods used in various applications, such as bioelectronics and SCL manufacturing. ,− Direct printing involves depositing a material directly onto a substrate in a controlled pattern, which can be categorized into two types, i.e., contact printing and noncontact printing. In contact printing, the printing material is transferred to the substrate by direct contact, while in noncontact printing, the material is deposited onto the substrate without physical contact.…”

Section: Technologies Overviewmentioning

confidence: 99%

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Seo,

Chung,

Kwon

et al. 2023

Chem. Rev.

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The eye contains a complex network of physiological information and biomarkers for monitoring disease and managing health, and ocular devices can be used to effectively perform point-of-care diagnosis and disease management. This comprehensive review describes the target biomarkers and various diseases, including ophthalmic diseases, metabolic diseases, and neurological diseases, based on the physiological and anatomical background of the eye. This review also includes the recent technologies utilized in eyewearable medical devices and the latest trends in wearable ophthalmic devices, specifically smart contact lenses for the purpose of disease management. After introducing other ocular devices such as the retinal prosthesis, we further discuss the current challenges and potential possibilities of smart contact lenses.

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“…Inkjet printing has garnered considerable attention amongst pharmaceutical scientist for its versatility in producing personalised medicines and unique dosage forms ( Alomari et al, 2015 ; Scoutaris et al, 2016a ). Notably, inkjet printing has been used to load drugs onto orodispersible films ( Alomari et al, 2018 ; Arshad et al, 2020 ; Jachowicz, 2017 ; Kiefer et al, 2021 ; Vuddanda et al, 2018 ), bioadhesive films for cervical administration ( Varan et al, 2017 ), transdermal microneedles ( Boehm et al, 2014 ; Uddin et al, 2015 ), coronary metal stents ( Scoutaris et al, 2016b ), contact lenses ( Pollard et al, 2023 ; Tetyczka et al, 2022 ), and even nails ( Pollard et al, 2022 ). Inkjet printing has also been used to dispense drug-loaded micro- and nanoparticles dispersed in the ink liquid ( Akagi et al, 2014 ; Boehm et al, 2013 ; Chou et al, 2021 ; Lee et al, 2012 ; Yeo et al, 2004 ).…”

Section: Introductionmentioning

confidence: 99%