Injury to the Endothelial Glycocalyx in Critically Ill Patients with COVID-19

Stahl, Klaus; Gronski, Phillip Alexander; Kiyan, Yulia; Seeliger, Benjamin; Bertram, Anna; Pape, Thorben; Welte, Tobias; Hoeper, Marius M.; Haller, Hermann; David, Sascha

doi:10.1164/rccm.202007-2676le

Cited by 110 publications

(142 citation statements)

References 9 publications

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“…As shown in Table 2 , a total of 16 studies were included for the title and abstract screening, and 2 studies were excluded due to duplicates. After a total of 11 studies were not deemed eligible for full-text review, 6 reports [ 3 , 87 , 88 , 89 , 90 , 91 ] were included in the review. Figure 14 presents a flowchart depicting the selection process.…”

Section: Literature Search Results For Veglx In Covid-19mentioning

confidence: 99%

Vascular Endothelial Glycocalyx Damage in COVID-19

Yamaoka‐Tojo

2020

IJMS

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The new coronavirus disease-2019 (COVID-19), which is spreading around the world and threatening people, is easily infecting a large number of people through airborne droplets; moreover, patients with hypertension, diabetes, obesity, and cardiovascular disease are more likely to experience severe conditions. Vascular endothelial dysfunction has been suggested as a common feature of high-risk patients prone to severe COVID-19, and measurement of vascular endothelial function may be recommended for predicting severe conditions in high-risk patients with COVID-19. However, fragmented vascular endothelial glycocalyx (VEGLX) is elevated in COVID-19 patients, suggesting that it may be useful as a prognostic indicator. Although the relationship between VEGLX and severe acute respiratory syndrome coronavirus 2 infections has not been well studied, some investigations into COVID-19 have clarified the relationship between VEGLX and the mechanism that leads to severe conditions. Clarifying the usefulness of VEGLX assessment as a predictive indicator of the development of severe complications is important as a strategy for confronting pandemics caused by new viruses with a high affinity for the vascular endothelium that may recur in the future.

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Section: Literature Search Results For Veglx In Covid-19mentioning

confidence: 99%

Vascular Endothelial Glycocalyx Damage in COVID-19

Yamaoka‐Tojo

2020

IJMS

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“… 48 The health (thickness and permeability) of the glycocalyx barrier is therefore critical to a range of diseases, for example, acute respiratory distress syndrome and COVID-19. 49 , 50 The glycocalyx can be remodeled by heparinase during inflammation; however, how the underlying endothelial adhesion molecules become accessible to leukocytes is not yet understood. 48 We are now investigating whether certain chemokines, for example, CXCL4, can physically remodel the glycocalyx structure to increase permeability and enable leukocyte rolling.…”

Section: Do Chemokine:gag Interactions Enable Immune Cell Recruitmentmentioning

confidence: 99%

Perspectives on the Biological Role of Chemokine:Glycosaminoglycan Interactions

Handel

Dyer

2020

J Histochem Cytochem.

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“…Hence glycocalyx destruction seems to mediate severe COVID-19. Recently, Stahl et al demonstrated that COVID-19 patients experience an acquired loss of the protective heparanase 2 and an increase in PBR ( 50 ). However, future research should be conducted to give further insights into the natural course of disease pathology and the role of HS.…”

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confidence: 99%