Injury Severity is a Key Contributor to Coagulation Dysregulation and Fibrinogen Consumption
Andrew R. Gosselin,
Christopher G. Bargoud,
Abhishek Sawalkar
et al.
Abstract:Background: Traumatic injury is a leading cause of death for those under the age of 45, with 40% occurring due to hemorrhage. Severe tissue injury and hypoperfusion lead to marked changes in coagulation, thereby preventing formation of a stable blood clot and increasing hemorrhage associated mortality. Objectives: We aimed to quantify changes in clot formation and mechanics occurring after traumatic injury and the relationship to coagulation kinetics, and fibrinolysis. Methods: Plasma was isolated from injured… Show more
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