Injury-prone: peripheral nerve injuries associated with prone positioning for COVID-19-related acute respiratory distress syndrome

Malik, George R.; Wolfe, Alexis R.; Soriano, Rachna; Rydberg, Leslie; Wolfe, Lisa F.; Deshmukh, Swati; Ko, Jason H.; Nussbaum, Ryan; Dreyer, Sean; Jayabalan, Prakash; Walter, James M.; Franz, Colin K.

doi:10.1016/j.bja.2020.08.045

Cited by 86 publications

(92 citation statements)

References 11 publications

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“…Peripheral neuropathy in the setting of COVID-19 has increasingly been reported [ 5 , 6 , 12 , 16 – 20 ]. Mechanisms of nerve involvement in COVID-19 are not fully understood.…”

Section: Nervesmentioning

confidence: 99%

“…Iatrogenic peripheral neuropathy has been reported in the setting of COVID-19 with a higher-than-expected incidence, raising the possibility that the SARS-CoV-2 virus may predispose peripheral nerves to injury via theoretical mechanisms that have yet to be firmly established [ 12 , 19 , 20 ]. COVID-19 patients may plausibly be more susceptible to iatrogenic nerve injuries secondary to a virus-induced state of hyperinflammation or overlapping comorbidities that predispose to both nerve injury and severe COVID-19 symptoms that necessitate hospitalization [ 20 ]. Prone positioning for optimization of oxygenation in hospitalized COVID-19 patients has been widely adopted; while life-saving, these measures may have adverse effects on the peripheral nervous system [ 27 ].…”

Section: Nervesmentioning

confidence: 99%

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Musculoskeletal involvement of COVID-19: review of imaging

et al. 2021

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The global pandemic of coronavirus disease 2019 (COVID-19) has revealed a surprising number of extra-pulmonary manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. While myalgia is a common clinical feature of COVID-19, other musculoskeletal manifestations of COVID-19 were infrequently described early during the pandemic. There have been emerging reports, however, of an array of neuromuscular and rheumatologic complications related to COVID-19 infection and disease course including myositis, neuropathy, arthropathy, and soft tissue abnormalities. Multimodality imaging supports diagnosis and evaluation of musculoskeletal disorders in COVID-19 patients. This article aims to provide a first comprehensive summary of musculoskeletal manifestations of COVID-19 with review of imaging.

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“…Peripheral neuropathy in the setting of COVID-19 has increasingly been reported [ 5 , 6 , 12 , 16 – 20 ]. Mechanisms of nerve involvement in COVID-19 are not fully understood.…”

Section: Nervesmentioning

confidence: 99%

Section: Nervesmentioning

confidence: 99%

Musculoskeletal involvement of COVID-19: review of imaging

et al. 2021

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“…Malik et al [ 124 ] studied 83 patients after hospitalization for ARDS due to COVID-19. Of these patients, 12 (14.5%) showed peripheral nerve injury.…”

Section: Potential Neurological Issues With the Prone Positioning In mentioning

confidence: 99%

Peripheral Nervous System Manifestations Associated with COVID-19

Andalib

Biller

Napoli

et al. 2021

Curr Neurol Neurosci Rep

136

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Purpose of Review The present review discusses the peripheral nervous system (PNS) manifestations associated with coronavirus disease 2019 (COVID-19). Recent Findings Nerve pain and skeletal muscle injury, Guillain-Barré syndrome, cranial polyneuritis, neuromuscular junction disorders, neuro-ophthalmological disorders, neurosensory hearing loss, and dysautonomia have been reported as PNS manifestations in patients with COVID-19. Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19. COVID-19 has shown syndromic complexity. Not only does SARS-CoV-2 affect the central nervous system but also it involves the PNS. The PNS involvement may be due to dysregulation of the immune system attributable to COVID-19. Here we review the broad spectrum of PNS involvement of COVID-19.

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“… 29 In a UK cohort of 100 patients, pain was the sixth most frequently reported persistent symptom on average 48 days after discharge, especially in patients who had been treated at an intensive care unit (ICU; 30%) but also in about 15% of the ward patients. 35 Furthermore, regarding the recommended prone position during moderate to severe acute respiratory distress syndrome due to SARS-CoV2, complications such as peripheral nerve injury have recently been reported, 50 which may lead to chronic neuropathic pain.…”

Section: Postinfectious Pain Associated With Expected Long-term Comentioning

confidence: 99%

Pain during and after COVID-19 in Germany and worldwide: a narrative review of current knowledge

Meyer-Frießem

Gierthmühlen

Baron

et al. 2021

PR9

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Pain is a common symptom accompanying the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Nonspecific discomfort such as sore throat and body ache are frequent. Parainfectious pain such as headache, myalgia, or neuropathic pain has also been reported. The latter seems to be associated with an autoimmune response or an affection of the peripheral neuromuscular system or the central nervous system because of the viral infection. Furthermore, chronic pain can be a complication of intensive care unit treatment due to COVID-19 itself (such as intensive care-acquired weakness) or of secondary diseases associated with the SARS-CoV-2 infection, including Guillain-Barr é syndrome, polyneuritis, critical illness polyneuropathy, or central pain following cerebrovascular events. Data on long-lasting painful symptoms after clinically manifest COVID-19 and their consequences are lacking. In addition, preexisting chronic pain may be exacerbated by limited and disrupted health care and the psychological burden of the COVID-19 pandemic. Medical providers should be vigilant on pain during and after COVID-19.

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Injury-prone: peripheral nerve injuries associated with prone positioning for COVID-19-related acute respiratory distress syndrome

Cited by 86 publications

References 11 publications

Musculoskeletal involvement of COVID-19: review of imaging

Musculoskeletal involvement of COVID-19: review of imaging

Peripheral Nervous System Manifestations Associated with COVID-19

Pain during and after COVID-19 in Germany and worldwide: a narrative review of current knowledge

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