Injury of the corticoreticular pathway in patients with proximal weakness following cerebral infarct: Diffusion tensor tractography study

Delayed gait disturbance due to injury of the corticoreticular pathway in a patient with mild traumatic brain injury

“…This result indicates the importance of CRP evaluation to elucidate the cause of proximal weakness in patients with head trauma. Several studies have reported on CRP injury using DTI [2][3][4][5]. However, regarding CRP injury with TBI, to the best of the authors' knowledge, only one patient has been reported.…”

“…Recently, use of diffusion tensor imaging has enabled reconstruction of the CRP in the live human brain (DTI) [2]. Therefore, several studies have reported on injury of the CRP in several brain pathologies, including intracerebral haemorrhage, cerebral infarct and traumatic brain injury (TBI) [3][4][5].…”

The different maturation of the corticospinal tract and corticoreticular pathway in normal brain development: diffusion tensor imaging study

“…For analysis of the CST, the seed region of interest (ROI) was placed on the CST portion of the pontomedullary junction, and the target ROI on the CST portion of the anterior mid-pons (Yeo et al, 2012b; Seo and Jang, 2013). For analysis of the CRP, the seed ROI was placed on the reticular formation of the medulla, and the target ROI on the midbrain tegmentum (Yeo et al, 2012a, 2013; Do et al, 2013; Jang et al, 2013; Figure 2A). The CST and CRP were determined by selection of fibers passing through seed and target ROIs (Figure 2B).…”

“…The CST is known to be primarily involved in fine motor skills, such as hand function (York, 1987; Ahn et al, 2006; Schaechter et al, 2009; Lo et al, 2010; Wang et al, 2010). On the contrary, the corticoreticular pathway (CRP), one of the extrapyramidal motor pathways, is known to be concerned with innervation of the proximal and axial muscles involved in gross motor skills, such as postural control and locomotion (Matsuyama et al, 2004; Yeo et al, 2012a,b, 2013; Do et al, 2013). These different functional roles of the CST and CRP in motor control have been reported in many previous studies using diffusion tensor imaging (DTI; Ahn et al, 2006; Schaechter et al, 2009; Yeo et al, 2012b, 2013; Do et al, 2013; Jang et al, 2013).…”

“…Diffusion tensor tractography (DTT), a three-dimensional visualized version of DTI, provides a concrete description of the architecture and integrity of the CST and CRP (Ahn et al, 2006; Schaechter et al, 2009; Yeo et al, 2012a,b, 2013; Do et al, 2013; Jang et al, 2013). Several previous studies have demonstrated that DTI and DTT are very helpful in estimation of the state of neural tracts (Mori et al, 1999; Kunimatsu et al, 2004; Smith et al, 2004; Yeo et al, 2012b, 2013; Do et al, 2013; Jang et al, 2013). However, little is known about differences in maturation of the CST and CRP (Lebel and Beaulieu, 2011).…”