Injury and adaptive mechanisms in skeletal muscle

Cutlip, Robert G.; Baker, Brent A.; Hollander, Melinda S.; Ensey, James

doi:10.1016/j.jelekin.2008.06.007

Cited by 27 publications

(19 citation statements)

References 132 publications

(172 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since tissue injury increases production of inflammatory cytokines (as reviewed in [35,41,42]), we examined forelimb tissues for levels of TNF-alpha, IL-1alpha and IL-1beta. Flexor digitorum muscles and tendons, and forelimb bones (radius and ulna, and first row of carpal bones), had significantly increased inflammatory cytokines at the end of training (week 0) and at 12 weeks of task performance.…”

Section: Resultsmentioning

confidence: 99%

“…Greater motor performance deficits occur with shorter compared to longer rest cycles between bouts of muscle contractions [26]. Chronic stretch-shortening contractions studies show that skeletal muscle adaptation (defined as remodeling with functional gains) can occur if the muscle is able to compensate to the increased demands of an activity, but that maladaptive muscles changes (subdegenerative or subnecrotic injury with low levels of persistent inflammation and loss of function) occur if muscles are not able to meet these demands [25,35]. In bone, failure of adaptative process is also a key factor in microdamage and fatigue fracture mechanisms [28].…”

Section: Introductionmentioning

confidence: 99%

“…After tissue damage, inflammatory cells infiltrate tissues, which, along with injured cells, produce inflammatory cytokines and other mediators that either exacerbate damage or assist in tissue repair [35,41,42]. Inflammation and histopathology are often congruent [43], and the magnitude of an inflammatory response to tissue insult or overuse appears to be reflective of the extent of injury in the tissues [42,44-46].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The interaction of force and repetition on musculoskeletal and neural tissue responses and sensorimotor behavior in a rat model of work-related musculoskeletal disorders

Barbe

Gallagher

Massicotte

et al. 2013

BMC Musculoskelet Disord

117

178

View full text Add to dashboard Cite

BackgroundWe examined the relationship of musculoskeletal risk factors underlying force and repetition on tissue responses in an operant rat model of repetitive reaching and pulling, and if force x repetition interactions were present, indicative of a fatigue failure process. We examined exposure-dependent changes in biochemical, morphological and sensorimotor responses occurring with repeated performance of a handle-pulling task for 12 weeks at one of four repetition and force levels: 1) low repetition with low force, 2) high repetition with low force, 3) low repetition with high force, and 4) high repetition with high force (HRHF).MethodsRats underwent initial training for 4–6 weeks, and then performed one of the tasks for 12 weeks, 2 hours/day, 3 days/week. Reflexive grip strength and sensitivity to touch were assayed as functional outcomes. Flexor digitorum muscles and tendons, forelimb bones, and serum were assayed using ELISA for indicators of inflammation, tissue stress and repair, and bone turnover. Histomorphometry was used to assay macrophage infiltration of tissues, spinal cord substance P changes, and tissue adaptative or degradative changes. MicroCT was used to assay bones for changes in bone quality.ResultsSeveral force x repetition interactions were observed for: muscle IL-1alpha and bone IL-1beta; serum TNFalpha, IL-1alpha, and IL-1beta; muscle HSP72, a tissue stress and repair protein; histomorphological evidence of tendon and cartilage degradation; serum biomarkers of bone degradation (CTXI) and bone formation (osteocalcin); and morphological evidence of bone adaptation versus resorption. In most cases, performance of the HRHF task induced the greatest tissue degenerative changes, while performance of moderate level tasks induced bone adaptation and a suggestion of muscle adaptation. Both high force tasks induced median nerve macrophage infiltration, spinal cord sensitization (increased substance P), grip strength declines and forepaw mechanical allodynia by task week 12.ConclusionsAlthough not consistent in all tissues, we found several significant interactions between the critical musculoskeletal risk factors of force and repetition, consistent with a fatigue failure process in musculoskeletal tissues. Prolonged performance of HRHF tasks exhibited significantly increased risk for musculoskeletal disorders, while performance of moderate level tasks exhibited adaptation to task demands.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The interaction of force and repetition on musculoskeletal and neural tissue responses and sensorimotor behavior in a rat model of work-related musculoskeletal disorders

Barbe

Gallagher

Massicotte

et al. 2013

BMC Musculoskelet Disord

117

178

View full text Add to dashboard Cite

show abstract

“…One important risk factor for MSDs is force level or load on the joint (Silverstein et al, 1997; Bernard, 1997; Punnett et al, 2004; Fan et al, 2009). Skeletal muscle can generate large internal forces on the joints, tendons and nerve during movement that may lead to MSDs (Cutlip et al, 2009). Surface electromyography (EMG) and EMG-assisted spine loading models have been used to assess internal forces acting on the spine and the risk of low back disorders (Kim and Marras, 1987; Marras and Sommerich, 1991a; McGill and Norman, 1986; Garnder-Morse et al, 1995; Potvin, 2008).…”

Section: Introductionmentioning

confidence: 99%

Musculoskeletal disorder risk during automotive assembly: current vs. seated

et al. 2012

View full text Add to dashboard Cite

Musculoskeletal disorder risk was assessed during automotive assembly processes. The risk associated with current assembly processes was compared to using a cantilever chair intervention. Spine loads and normalized shoulder muscle activity were evaluated during assembly in eight regions of the vehicle. Eight interior cabin regions of the vehicle were classified by reach distance, height from vehicle floor and front to back. The cantilever chair intervention tool was most effective in the far reach regions regardless of the height. In the front far reach regions both spine loads and normalized shoulder muscle activity levels were reduced. In the middle and close reach regions spine loads were reduced, however, shoulder muscle activity was not, thus an additional intervention would be necessary to reduce shoulder risk. In the back far reach region, spine loads were not significantly different between the current and cantilever chair conditions. Thus, the effectiveness of the cantilever chair was dependent on the region of the vehicle.

show abstract

“…As can be surmised by the breadth of the description of MSDs by the BLS nomenclature, the spectrum of disorders, conditions, and diseases are numerous (i.e., ranging from overt soft-tissue injury to overexertion and repetitive use events that may lead to the maladaptation of soft tissue without overt injury) and, indeed, include those states where alterations (both in function and physiology) are effected [21,22]. MSDs such as soft-tissue strain/sprain injury that result from mechanical/physical loading of soft-tissue are clinically diagnosable injuries/disorders and can result following exposure in any environment and at any age.…”

Section: Musculoskeletal Disorders (Msds): Dynapenia Sarcopenia Andmentioning

confidence: 99%

Efficacy of Age-Specific High-Intensity Stretch-Shortening Contractions in Reversing Dynapenia, Sarcopenia, and Loss of Skeletal Muscle Quality

Baker

2018

JFMK

View full text Add to dashboard Cite

During the aging process, skeletal muscle performance and physiology undergoes alterations leading to decrements in functional capacity, health-span, and independence. Background: The utility and implementation of age-specific exercise is a paramount research agenda focusing on ameliorating the loss of both skeletal muscle performance and physiology; yet, to date, no consensus exists as to the most appropriate mechanical loading protocol design or overall exercise prescription that best meets this need. Thus, the purpose of this review is to highlight the most optimal type of exercise presently available and provide the most current, evidence-based findings for its efficacy. The hypothesis that high-intensity, stretch-shortening contractions (SSCs)-a form of "resistance-type exercise" training-present as the preferred exercise mode for serving as an intervention-based modality to attenuate dynapenia, sarcopenia, and decreased muscle quality with aging, even restoring the overall youthful phenotype, will be demonstrated. Conclusions: Appreciating the fundamental evidence supporting the use of high-intensity SSCs in positively impacting aging skeletal muscle's responsivity and their use as a specific and sensitive countermeasure is crucial. Moreover, from an applied perspective, SSCs may improve skeletal muscle quality and rejuvenate health-span and, ultimately, lead to augmented functional capacity, independence, and quality of life concomitant with decreased morbidity.

show abstract

Injury and adaptive mechanisms in skeletal muscle

Cited by 27 publications

References 132 publications

The interaction of force and repetition on musculoskeletal and neural tissue responses and sensorimotor behavior in a rat model of work-related musculoskeletal disorders

The interaction of force and repetition on musculoskeletal and neural tissue responses and sensorimotor behavior in a rat model of work-related musculoskeletal disorders

Musculoskeletal disorder risk during automotive assembly: current vs. seated

Efficacy of Age-Specific High-Intensity Stretch-Shortening Contractions in Reversing Dynapenia, Sarcopenia, and Loss of Skeletal Muscle Quality

Contact Info

Product

Resources

About