Injuries of the Cingulum and Fornix After Rupture of an Anterior Communicating Artery Aneurysm

Hong, Ji Heon; Choi, Byung Yeon; Chang, Chul Hoon; Kim, Seong Ho; Jung, Young Jin; Byun, Woo Mok; Jang, Sung Ho

doi:10.1227/neu.0b013e3182367124

Cited by 31 publications

(38 citation statements)

References 30 publications

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“…The anterior cingulum has been associated with both verbal and visual spatial memory (Kantarci et al, 2011; Mielke et al, 2009) as well as the fornix (Mielke et al, 2009; Palacios et al, 2011). The cingulum and fornix are major components of the Papez circuit (Abdul-Rahman et al, 2011; Hong et al, 2012; Shah et al, 2012), a circuit known for the formation of new memories (episodic). Damage to this circuit results in anterograde amnesia (Thomas et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Characterization of a normal control group: Are they healthy?

Aine¹,

Sanfratello²,

Adair³

et al. 2014

NeuroImage

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We examined the health of a control group (18–81 years) in our aging study, which is similar to control groups used in other neuroimaging studies. The current study was motivated by our previous results showing that one third of the elder control group had moderate to severe white matter hyperintensities and/or cortical volume loss which correlated with poor performance on memory tasks. Therefore, we predicted that cardiovascular risk factors (e.g., hypertension, high cholesterol) within the control group would account for significant variance on working memory task performance. Fifty-five participants completed 4 verbal and spatial working memory tasks, neuropsychological exams, diffusion tensor imaging (DTI), and blood tests to assess vascular risk. In addition to using a repeated measures ANOVA design, a cluster analysis was applied to the vascular risk measures as a data reduction step to characterize relationships between conjoint risk factors. The cluster groupings were used to predict working memory performance. The results show that higher levels of systolic blood pressure were associated with: 1) poor spatial working memory accuracy; and 2) lower fractional anisotropy (FA) values in multiple brain regions. In contrast, higher levels of total cholesterol corresponded with increased accuracy in verbal working memory. An association between lower FA values and higher cholesterol levels were identified in different brain regions from those associated with systolic blood pressure. The conjoint risk analysis revealed that Risk Cluster Group 3 (the group with the greatest number of risk factors) displayed: 1) the poorest performance on the spatial working memory tasks; 2) the longest reaction times across both spatial and verbal memory tasks; and 3) the lowest FA values across widespread brain regions. Our results confirm that a considerable range of vascular risk factors are present in a typical control group, even in younger individuals, which have robust effects on brain anatomy and function. These results present a new challenge to neuroimaging studies both for defining a cohort from which to characterize `normative' brain circuitry and for establishing a control group to compare with other clinical populations.

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Section: Discussionmentioning

confidence: 99%

Characterization of a normal control group: Are they healthy?

Aine¹,

Sanfratello²,

Adair³

et al. 2014

NeuroImage

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“…Since introduction of DTI, many studies have investigated injury of the cingulum in various brain pathologies, including subarachnoid hemorrhage, traumatic brain injury, and hypoxic ischemic brain injury (Sugiyama et al, 2009; Wilde et al, 2010, 2011; Wu et al, 2010; McCauley et al, 2011; Wang et al, 2011; Hong et al, 2012; Lee et al, 2012; Baek et al, 2013; Sanjuan et al, 2013; Zheng et al, 2013). Most of these studies investigated injury of the cingulum using DTI parameters [Sugiyama et al, 2009; Wilde et al, 2010, 2011; Wu et al, 2010; McCauley et al, 2011; Wang et al, 2011; Hong et al, 2012; Lee et al, 2012; Sanjuan et al, 2013; Zheng et al, 2013 (Epub ahead of print)].…”

Section: Discussionmentioning

confidence: 99%

“…Most of these studies investigated injury of the cingulum using DTI parameters [Sugiyama et al, 2009; Wilde et al, 2010, 2011; Wu et al, 2010; McCauley et al, 2011; Wang et al, 2011; Hong et al, 2012; Lee et al, 2012; Sanjuan et al, 2013; Zheng et al, 2013 (Epub ahead of print)]. Only a few studies have reported that discontinuation of the anterior cingulum was related to cognitive dysfunction following brain injury (Baek et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Injury of the cingulum in patients with putaminal hemorrhage: a diffusion tensor tractography study

Kwon

Choi

Kim

et al. 2014

Front. Hum. Neurosci.

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Objectives: Little is known about the pathophysiological mechanisms of cognitive impairment in patients with putaminal hemorrhage (PH). Using diffusion tensor tractography, we investigated injury of the cingulum in patients with PH.Methods: We recruited 63 patients with PH, who were classified according to three groups, based on integrity of the cingulum to the lower portion of the genu of the corpus callosum: group A; preserved integrity, group B; discontinuation of integrity in the affected hemisphere, and group C; discontinuation of integrity in both hemispheres.Results: Thirty four patients (54.0%) belonged to group A, 16 patients (25.4%) to group B, and the remaining 13 patients (20.6%) to group C. Regarding the Mini-Mental State Examination, significant differences were observed between group A and group C, and between group B and group C without significant difference between group A and group B (p < 0.05). In terms of the volume of hematoma, significant differences were observed among the three groups (p < 0.05). Regarding the most anterior point of the hematoma, significant differences were observed between group A and groups B and C (p < 0.05); in contrast, regarding the most point of hematoma, significant differences were observed between group C and groups A and B, respectively (p < 0.05).Conclusion: We found that the anterior cingulum is vulnerable to PH. Therefore, our results suggest the necessity for evaluation of the cingulum in patients with PH particularly if the hematoma is large or close to the anterior margin or midline of the brain.

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“…35 However, the authors did not analyze the sites of lesions or present the neuropsychological data of their cases. On the contrary, all our patients demonstrated infarction in the column of the fornix and underwent formal neuropsychological tests, which indicated their disproportionate impairment of memory but only limited intellectual decline [IQ Ϫ MQ ϭ 26 (mean), all Ͼ 15].…”

Section: Figmentioning

confidence: 99%

MR Imaging of Subcallosal Artery Infarct Causing Amnesia after Surgery for Anterior Communicating Artery Aneurysm

Mugikura¹,

Kikuchi

Fujii

et al. 2014

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: During surgery to treat an aneurysm in the anterior communicating artery, injury to the subcallosal artery, a perforator of the anterior communicating artery, may lead to infarction that produces basal forebrain amnesia after surgery. Our purpose was to examine whether 3D MR imaging can detect subcallosal artery infarction in patients with amnesia after surgery for an anterior communicating artery aneurysm.

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Injuries of the Cingulum and Fornix After Rupture of an Anterior Communicating Artery Aneurysm

Cited by 31 publications

References 30 publications

Characterization of a normal control group: Are they healthy?

Characterization of a normal control group: Are they healthy?

Injury of the cingulum in patients with putaminal hemorrhage: a diffusion tensor tractography study

MR Imaging of Subcallosal Artery Infarct Causing Amnesia after Surgery for Anterior Communicating Artery Aneurysm

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