Injektabel Komposit Hydroksiapatit-Gelatin sebagai Sistem Penghantaran Alendronat

Budiatin, Aniek Setiya; Khotib, Junaidi; Hasmono, Didik; Samirah, -

doi:10.20473/jfiki.v3i1.4085

Cited by 2 publications

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“…The hydroxyapatite has been used in the pharmacy fields such as tablet making (Mustaqim, 2017), dental implant (Sidiqa et al, 2012), injection manufacture (Budiatin et al, 2016). However, there was not an investigation on making toothpaste from hydroxyapatite tenggiri fish bone, hence this studyis conducted to investigate hydroxyapatite toothpaste that can cover the holes in the teeth.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite (HAp) From Tenggiri Fish Bones As Abrasive Material In Toothpaste Formula

Anggresani¹,

Sari²,

Rahmadevi³

2021

Valensi

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Cavities are one of the factors of dental and oral health problems that can be prevented by brushing teeth using toothpaste. Toothpaste can be made from a variety of chemicals, one of which is hydroxyapatite (HAp) which has good biocompatible properties. Hydroxyapatite can be obtained by utilizing tenggiri fish bone waste which has the main element of calcium. Fish bones soaked with NaOH and acetone are then calcined at 800 °C for 3 hours to obtain CaO powder and characterized its elemental content using X-Ray Fluorescence (XRF). CaO obtained was then reacted with (NH4)2HPO4 with a mole ratio of Ca/P 1.67 then heated at 90 °C, added NaOH up to pH 12, then the obtained deposits are filtered and calcined at 900 °C. The solids obtained from the calcination are then characterized using X-Ray Diffraction (XRD) and Scanning Electron Microscope (SEM). Hydroxyapatite (HAp) was formulated into toothpaste with the concentrations of 0% (F0), 45% (F1), 50% (F2), and 55% (F3). Toothpaste was evaluated using organoleptic tests, homogeneity tests, foam height tests, spreadability tests, pH and hedonic tests. XRD analysis shows that the resulting hydroxyapatite (HAp) has a crystal structure in accordance with ICSD standard No. 96-900-3549. SEM analysis showed that granular particles measuring 0.1 μm–0.3 μm in size. All formulated toothpastes (F0, F1, F2, and F3) meet the requirements of a good toothpaste. Hydroxyapatite (HAp) can be formulated into a good toothpaste with a concentration of 45%.

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Section: Introductionmentioning

confidence: 99%

Hydroxyapatite (HAp) From Tenggiri Fish Bones As Abrasive Material In Toothpaste Formula

Anggresani¹,

Sari²,

Rahmadevi³

2021

Valensi

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Effect of Glutaraldehyde Concentration Variation on Diclofenac Sodium Scaffolds as Cross-Linking Agent

Budiatin

Su’aida

Lamakluang

et al. 2022

RJPT

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Chitosan and gelatin were used as polymer scaffolds for cartilage tissue engineering. The scaffold was used as a biodegradable drug delivery system for diclofenac sodium to treat cartilage defects on osteoarthritis (OA). The materials were composed of diclofenac sodium, chitosan, gelatin, and cross-linking agent-glutaraldehyde (GTA) were form as scaffold. The purpose of this study to investigate the effect of GTA concentration variations (0.00%; 0.25%; 0.50%; 1.00%; 2.50%) on characteristics and the release of diclofenac sodium from chitosan-gelatin scaffold. The scaffolds were made by using the pre-freezing method with a temperature of -56 ± 5°C for 24 hours and characterized by porosity, pore size, swelling, degradation, toxicity test, and diclofenac sodium released from chitosan-gelatin scaffolds at pH and temperature body. The results showed, the addition of GTA increased the swelling ratio from 195.79 ± 7.04% to 793.49 ± 6.92% and minimized weight loss up to 50.98 ± 0.82%, percentage of living cells >60%, optimal porosity at 106.94 ± 9.38 % with pore size 135.48 ± 89.70 µm, diclofenac sodium as sustained release drug completed in 542 hours and the release was following zero-order kinetic. Chitosan-gelatin scaffold is a potential candidate for cartilage tissue engineering and drug delivery system for diclofenac sodium.

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Injektabel Komposit Hydroksiapatit-Gelatin sebagai Sistem Penghantaran Alendronat

Cited by 2 publications

References 0 publications

Hydroxyapatite (HAp) From Tenggiri Fish Bones As Abrasive Material In Toothpaste Formula

Hydroxyapatite (HAp) From Tenggiri Fish Bones As Abrasive Material In Toothpaste Formula

Effect of Glutaraldehyde Concentration Variation on Diclofenac Sodium Scaffolds as Cross-Linking Agent

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