Injections of dopaminergic, cholinergic, serotoninergic and gabaergic drugs into the nucleus accumbens: effects on locomotor activity in the rat

Jones, Douglas L.; Mogenson, Gordon J.; Wu, Michael

doi:10.1016/0028-3908(81)90038-1

Cited by 201 publications

(65 citation statements)

References 44 publications

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“…It is possible that this attenuated effect may have been due to a complex interaction between the serotonin and dopamine systems. Indeed, both systems have been shown to interact at a neuronal level, although the functional relevance of this interaction has not been fully determined (Costall et al, 1976;Jones et al, 1981;Parsons and Justice, 1993;Soubrie et al, 1984). It is possible that tryptophan depletion may result in the removal of serotonin's inhibitory influence on dopamine and noradrenaline neurotransmission (Gately et al, 1985;Lucki and Harvey, 1976;McRae-Degueurce et al, 1985;Segal, 1976;Tian et al, 1993), and this disinhibition is counteracted by simultaneous tyrosine depletion (impacting upon dopamine neurotransmission), thus resulting behaviorally in an attenuated effect on cognitive control.…”

Section: Discussionmentioning

confidence: 99%

Acute Serotonin and Dopamine Depletion Improves Attentional Control: Findings from the Stroop Task

Scholes

Harrison

O’Neill

et al. 2006

Neuropsychopharmacol

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Schizophrenia is associated with impairments of attentional control on classic experimental paradigms such as the Stroop task. However, at a basic level the neurochemical mechanisms that may be responsible for such impairments are poorly understood. In this study, we sought to investigate the influence of brain monoamine function on Stroop task performance in healthy participants using the established methods of acute dietary serotonin, dopamine, and combined monoamine depletion. The study was a double-blind placebo controlled design in which 12 healthy male participants completed the Stroop task under four acute treatment conditions: (a) balanced/placebo control, (b) acute tryptophan depletion, (c) acute tyrosine/phenylalanine depletion, and (d) acute tyrosine/phenylalanine/tryptophan depletion (combined monoamine depletion). Decreased Stroop interference indicating improved attentional control was observed after both tryptophan depletion and tyrosine/phenylalanine depletion, while there was no significant change in interference after combined monoamine depletion. Findings suggest that reduced tonic dopamine or serotonin activity within specific neural circuits (such as the striatum, anterior cingulate, or prefrontal cortex) may play a critical role in attentional control, possibly by improving gating of information via reducing noise in monoaminergic systems. These findings enhance our understanding of the neurochemical basis of attentional control and the possible cause of attentional control deficits in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Acute Serotonin and Dopamine Depletion Improves Attentional Control: Findings from the Stroop Task

Scholes

Harrison

O’Neill

et al. 2006

Neuropsychopharmacol

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“…GABAergic receptors in the nucleus accumbens also have been implicated in this respect (Jones et al, 1981). Moreover, the noradrenergic system seems involved in the apomorphine-induced hypoactivity (Sumners et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

The hypomotility elicited by small doses of apomorphine seems exclusively mediated by dopaminergic systems in the nucleus accumbens

Radhakishun

Ree

1987

European Journal of Pharmacology

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The reduction of motor activity elicited in rats by a subcutaneous injection of a small dose of apomorphine was reversed by pretreatment of the nucleus accumbens with haloperidol (10 pg), sulpiride (10 pg) or desenkephalin--f-endorphin (DE),E) (100 pg or 10 ng). These doses of the compounds did not change motor activity in placebo-treated rats. Pretreatment of the nucleus caudatus with the same neuroleptics or DE'rE did not diminish the effect of subcutaneously administered low doses of apomorphine. A small dose of apomorphine decreased motor activity when it was injected directly into the nucleus accumbens. This effect was dose dependently antagonized by subcutaneous pretreatment with DE~,E. It is suggested that the hypoactivity elicited by small doses of apomorphine is exclusively mediated by dopaminergic systems in the nucleus accumbens.

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“…Several studies in rodents have pointed out that the projection of the nucleus accumbens to the ventral pallidum is GABAergic in nature (Mogenson et al, 1980;. Pharmacological manipulations of this inhibitory pathway have demonstrated that this projection is essential for the modulation of locomotor behavior (eg Jones et al, 1981;Mogenson and Nielsen, 1983;Swerdlow and Koob, 1987). Hence, we hypothesize that stimulation of the GABA A receptors by infusing muscimol into the core subregion will lead to a reduced firing of the neurons present in the core.…”

Section: Effects Of Muscimol Infusion In the Core Or The Shell On Actmentioning

confidence: 84%

“…At the same time, other neurotransmitter systems within the nucleus accumbens, such as the dopaminergic system, can exert concomitant effects on the altered accumbal GABAergic system. Notably, damage to this neurotransmitter system as well as stimulation via dopaminergic agonists infused into the accumbens has been shown to result in enhanced locomotor activity (eg Boye et al, 2001;Jones et al, 1981;Parkinson et al, 1999;Sellings and Clarke, 2003; but see Taghzouti et al, 1985).…”

Section: Effects Of Muscimol Infusion In the Core Or The Shell On Actmentioning

confidence: 99%

The Effects of Temporary Inactivation of the Core and the Shell Subregions of the Nucleus Accumbens on Prepulse Inhibition of the Acoustic Startle Reflex and Activity in Rats

Pothuizen

Jongen-Rêlo

Feldon

2005

Neuropsychopharmacol

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The nucleus accumbens can be dissociated into at least two subregions: a 'core' and a 'shell'. Using temporary chemical inactivation of these subregions, we investigated whether they are differentially involved in the regulation of prepulse inhibition (PPI) of the acoustic startle reflex and activity. For this purpose, rats were bilaterally implanted with guide cannulae aimed at either the core or the shell and infused with the GABA A receptor agonist muscimol (0.5 mg/0.2 ml per side). The control group consisted of vehicle infused and unoperated rats. To ascertain the region selectivity of the infusions, 0.2 ml of [ 3 H]muscimol was infused into either the core or the shell of an additional group of rats. The behavioral results demonstrated that in comparison to the control group, inactivation of the core led to a loss of the prepulse intensity dependency of PPI. Moreover, core inactivation resulted in akinesia directly after infusion, but in hyperactivity 24 and 72 h thereafter in contrast to the control group. In both experiments, inactivation of the shell was ineffective compared to controls. Analysis of the autoradiograms revealed that the spread of drug into the other subregion was minimal, supporting the region selectivity of the inactivation. These results lend further support to the existence of a functional dissociation between the core and the shell, with the former being preferentially involved in PPI and locomotion. The persistent hyperactivity after the muscimol infusion into the core could be explained by compensatory mechanisms taking place in the nucleus accumbens.

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Injections of dopaminergic, cholinergic, serotoninergic and gabaergic drugs into the nucleus accumbens: effects on locomotor activity in the rat

Cited by 201 publications

References 44 publications

Acute Serotonin and Dopamine Depletion Improves Attentional Control: Findings from the Stroop Task

Acute Serotonin and Dopamine Depletion Improves Attentional Control: Findings from the Stroop Task

The hypomotility elicited by small doses of apomorphine seems exclusively mediated by dopaminergic systems in the nucleus accumbens

The Effects of Temporary Inactivation of the Core and the Shell Subregions of the Nucleus Accumbens on Prepulse Inhibition of the Acoustic Startle Reflex and Activity in Rats

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