Injections of Depot Antipsychotic Medications in Patients Suffering From Schizophrenia

Comparing Pain of the First-generation Long-Acting Antipsychotic Injections among Three Different IM Techniques

“…However, using the 10-point NRS for pain evaluation, the 5-minute post-injection did not show significance in pain level. In contrast, past researchers used the visual analog scale rating from 0 to 10, and found that the 5-minute post-injection pain level was between 2 and 4.5 [16]. However, pain levels did not show a significant difference in our study.…”

“…Past researchers did not describe whether the medication dosage for injection was different [15] or whether it was the same personnel who implemented the injection and set a standard protocol in the injection process, etc. [15,16], thus making it difficult to assess the effectiveness of various injection methods in reducing leakage and pain at the injection site. Although past literature has suggested different injection techniques for IM injection, findings remain inconclusive.…”

Efficacy and safety of long‐acting risperidone in elderly patients with schizophrenia and schizoaffective disorder

“…This will likely be a positive factor in influencing patients' acceptance of long-acting risperidone and an important advantage over conventional oil-based depot formulations, which often are associated with pain and other injection-site reactions (Hay, 1995;Bloch et al, 2001). Scores on the SF-36 scale indicated that treatment with long-acting risperidone was also associated with significant improvements in the quality of life of these elderly patients.…”

“…Gradual hydrolysis of the copolymer at the injection site ensures slow and steady release of risperidone over several weeks. Sustained-release aqueous-based agents may provide further benefits given that oil-based injections are associated with pain and other adverse events at the injection site (Hay, 1995;Bloch et al, 2001).…”

In vitro and in vivo demonstration of risperidone implants in mice

“…Additionally, depot injections are irreversible and thus lack flexibility in administration and clinical management (Barnes and Curson 1994). Depot treatments can also result in prolonged pain at the injection site, which increases the likelihood that patients will discontinue treatment (Bloch 2001;Kane et al 1998).…”