Injection Site Abscesses Caused by Mycobacterium Chelonei

Gremillion, David H.; Mursch, Sara B.; Lerner, Charles

doi:10.1017/s019594170005760x

Cited by 53 publications

(15 citation statements)

References 14 publications

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“…4,6,10,11 Saline flushes and other intravenous multidose medications have also been reported to transmit blood-borne pathogens such as malaria, human immunodeficiency virus, or bacteria. 1,[13][14][15][16][24][25][26][28][29][30][31][32][33][34][35] For at least four reports of nosocomial transmission of blood-borne pathogens, investigators were able to epidemiologically link the transmission to saline flushes of indwelling peripheral intravenous cannulas. However, none of these reports included HCV.…”

Section: Discussionmentioning

confidence: 99%

Nosocomial Transmission of Hepatitis C Virus Associated With the Use of Multidose Saline Vials

Krause

Trepka

Whisenhunt

et al. 2003

Infect. Control Hosp. Epidemiol.

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Objective:To identify the source of an outbreak of acute hepatitis C virus (HCV) infection among 3 patients occurring within 8 weeks of hospitalization in the same ward of a Florida hospital during November 1998.Design:A retrospective cohort study was conducted among 41 patients hospitalized between November 11 and 19, 1998. Patients' blood was tested for antibodies to HCV, and HCV RNA-positive samples were genotyped and sequenced.Results:Of the 41 patients, 24 (59%) participated in the study. HCV genotype 1b infections were found in 5 patients. Three of 4 patients who received saline flushes from a multidose saline vial on November 16 had acute HCV infection, whereas none of the 9 patients who did not receive saline flushes had HCV infection (P= .01). No other significant exposures were identified. The HCV sequence was available for 1 case of acute HCV and differed by a single nucleotide (0.3%) from that of the indeterminate case.Conclusion:This outbreak of HCV probably occurred when a multidose saline vial was contaminated with blood from an HCV-infected patient. Hospitals should emphasize adherence to standard procedures to prevent blood-borne infections. In addition, the use of single-dose vials or prefilled saline syringes might further reduce the risk for nosocomial transmission of blood-borne pathogens.

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Section: Discussionmentioning

confidence: 99%

Nosocomial Transmission of Hepatitis C Virus Associated With the Use of Multidose Saline Vials

Krause

Trepka

Whisenhunt

et al. 2003

Infect. Control Hosp. Epidemiol.

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“…Other outbreaks of M. chelonae-abscessus group infection have involved plastic surgery (52,146), hemodialysis, and miscellaneous outbreaks including wound infections following laparoscopy, liposuction (107), and post-tympanostomy tube placement (98). Additionally, postinjection abscess outbreaks following the use of multidose vials (15,62,129) or contaminated biologicals (30,33,57,183) also have been reported. Vaccine-related outbreaks involving M. chelonae-abscessus as contaminants also are recorded (59,119).…”

Section: Chelonae-abscessus Groupmentioning

confidence: 99%

“…The second type of infection seen with M. chelonae involves community-acquired localized infections following trauma (62,205,206,210). These infections range from localized cellulitis or abscess to osteomyelitis.…”

Section: Chelonae-abscessus Groupmentioning

confidence: 99%

Clinical and Taxonomic Status of Pathogenic Nonpigmented or Late-Pigmenting Rapidly Growing Mycobacteria

2002

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The history, taxonomy, geographic distribution, clinical disease, and therapy of the pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria (RGM) are reviewed. Community-acquired disease and health care-associated disease are highlighted for each species. The latter grouping includes health care-associated outbreaks and pseudo-outbreaks as well as sporadic disease cases. Treatment recommendations for each species and type of disease are also described. Special emphasis is on the Mycobacterium fortuitum group, including M. fortuitum, M. peregrinum, and the unnamed third biovariant complex with its recent taxonomic changes and newly recognized species (including M. septicum, M. mageritense, and proposed species M. houstonense and M. bonickei). The clinical and taxonomic status of M. chelonae, M. abscessus, and M. mucogenicum is also detailed, along with that of the closely related new species, M. immunogenum. Additionally, newly recognized species, M. wolinskyi and M. goodii, as well as M. smegmatis sensu stricto, are included in a discussion of the M. smegmatis group. Laboratory diagnosis of RGM using phenotypic methods such as biochemical testing and high-performance liquid chromatography and molecular methods of diagnosis are also discussed. The latter includes PCR-restriction fragment length polymorphism analysis, hybridization, ribotyping, and sequence analysis. Susceptibility testing and antibiotic susceptibility patterns of the RGM are also annotated, along with the current recommendations from the National Committee for Clinical Laboratory Standards (NCCLS) for mycobacterial susceptibility testing

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“…Os mais prováveis agentes de contaminação micobacteriana, indutores de surtos de micobacteriose pós-cirúrgica, são a água de serventia hospitalar, matérias, soluções e instrumentos utilizados nos procedimentos cirúrgicos (Foz et al, 1978;Gremillion et al, 1983;Wallace-Jr et al, 1998;Sethi et al, 2001;Phillips;Von Reyn, 2001;Winthrop et al, 2002;Mackay et al, 2002). Nesse sentido e visando ações profiláticas, foi investigada, por métodos bacteriológicos e moleculares, a presença de micobactérias ambientais em águas, soluções e luvas cirúrgicas, utilizadas nas etapas de procedimentos cirúrgicos executados no Hospital Universitário Getúlio Vargas (HUGV), pertencente à Universidade Federal do Amazonas (UFAM), na cidade de Manaus/AM.…”

Section: Introductionunclassified

Pesquisa de Micobactérias Ambientais em água de torneira, luvas e soluções utilizadas em procedimentos cirúrgicos no Hospital Universitário Getúlio Vargas - Manaus/AM

et al. 2009

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RESUMOInvestigou-se por métodos bacteriológicos (cultivo) e moleculares (PCR -Restriction Enzyme Analysis, PRA), a presença de micobactérias ambientais em águas de torneira, soluções e luvas cirúrgicas, utilizadas nas etapas dos procedimentos cirúrgicos executados no centro cirúrgico do Hospital Universitário Getulio Vargas (HUGV), na cidade de Manaus-Amazonas/Brasil. Foram colhidas e analisadas 105 amostras sendo: 24 de águas (colhidas das 2 torneiras existentes no centro cirúrgico), 8 de solução de Povidine e 7 de solução de Clorhexidina, que servem para a higienização das mãos dos cirurgiões; 39 de luvas cirúrgicas (superfícies internas e externas); e 27 de soluções que foram efetivamente utilizadas durante o ato cirúrgico. Por método bacteriológico obteve-se 41 isolados micobacterianos apenas de águas das torneiras. Pelo PRA obteve-se a detecção de DNA micobacteriano somente na amostra de água que forneceu acima de 100 colônias de micobactérias por tubo semeado. Os isolados foram identificados como sendo Mycobacterium celatum perfil 2, M. gordonae perfil 3, M. gordonae perfil 6, M. intracellulare perfil 1, M. lentiflavum perfil 3 e M. mucogenicum perfil 1. O encontro de M. mucogenicum, espécie já incriminada em surtos pós-cirúrgicos, indica que devem ser efetuados procedimentos de limpeza e monitoramento em todos os pontos de distribuição de águas, visando à prevenção de surtos de micobacterioses nosocomiais induzidos pelo uso das águas nas diferentes atividades de manuseio ou higienização dos pacientes submetidos a procedimentos invasivos. PALAVRAS-CHAVE:Micobactérias Ambientais, MNT, água, soluções anti-sépticas, luvas, procedimentos cirúrgicos. Investigation of Environmental Mycobacteria in tap water, surgical gloves and antiseptic solutions used in surgical procedures at the Getúlio Vargas University Hospital, Manaus-AM/BrazilABSTRACT Using bacteriological (culture) and molecular (PCR -Restriction Enzyme Analysis, PRA) methods, we investigated the presence of environmental mycobacteria in tap water, antiseptic solutions and surgical gloves, used in carrying out surgical procedures at the Getúlio Vargas University Hospital Surgical Center, in Manaus -Amazonas/Brazil. Samples (105) were collected and analyzed from: tap water (24 -collected from 3 taps in the surgical center); povidone-iodine solution, PVP-I, (8); Chlorhexidine solution (7), that were used to hygienize surgeons' hands; surgical gloves (39); and solutions that were effectively used during the surgical procedure (27). Using bacteriological method 41 mycobacteria were isolated, all from samples of tap water. Using PRA, mycobacterial DNA was detected only in the sample from water that provided over 100 colonies per inoculated culture tubes. The isolated were identified as Mycobacterium celatum pattern II, M. gordonae pattern III, M. gordonae pattern VI, M. intracellulare pattern I, M. lentiflavum pattern III and M. mucogenicum pattern I. The isolating of M. mucogenicum, a species that had already been incriminated for causing post-surgical outb...

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Injection Site Abscesses Caused by Mycobacterium Chelonei

Cited by 53 publications

References 14 publications

Nosocomial Transmission of Hepatitis C Virus Associated With the Use of Multidose Saline Vials

Nosocomial Transmission of Hepatitis C Virus Associated With the Use of Multidose Saline Vials

Clinical and Taxonomic Status of Pathogenic Nonpigmented or Late-Pigmenting Rapidly Growing Mycobacteria

Pesquisa de Micobactérias Ambientais em água de torneira, luvas e soluções utilizadas em procedimentos cirúrgicos no Hospital Universitário Getúlio Vargas - Manaus/AM

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