Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis

Sampson, Steven; Reed, Marty; Silvers, Holly J.; Meng, Michael; Mandelbaum, Bert R.

doi:10.1097/phm.0b013e3181fc7edf

“…No major complication such as deep infection, muscle atrophy, deep vein thrombosis, fever, hematoma, tissue hypertrophy, adhesion formation, or other major adverse events occurred among study subjects. Similar studies by Sampson S et al [6] , Filardo G et al [7] , Kon E et al [5] , Sun Y et al [8] and Giannini S et al [9] showed no major complication or adverse effects. In our study, three cases in GFRP group showed temporary worsening of pain for about 24 hours which resolved spontaneously.…”

Section: Discussionsupporting

confidence: 64%

Comparative study of static versus dynamic intramedullary nailing of tibia

Somani¹,

Saji²,

Rabari³

et al. 2017

Int. J. Orthop. Sci.

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Worldwide osteoarthritis is the most common joint disorder. It results from mechanical and biological events that destabilize the normal processes of degradation and synthesis of articular cartilage chondrocytes, extracellular matrix and subchondral bone. These changes include increased water content, decreased proteoglycan content and altered collagen matrix, leading to the degeneration of articular cartilage. There is trend on rise to use platelet rich plasma to promote healing of the degenerated cartilage. The aim of the study was to evaluate whether the newer method i.e platelet rich plasma has any significant advantage. The study included a total of 50 cases with individuals ageing greater than 40 years. Patients without evidence of degenerative arthritis and with KL grade 3 and grade 4 were excluded from the study. At 1 month only 14% cases showed excellent, 68% cases showed and. 18% cases showed fair results. At 3 months follow up 16% cases showed excellent, 82% cases showed good and fair results were seen in 2% cases. No case had poor results. At 6 months follow up 16% cases showed excellent, 86% cases showed good and 6% cases showed fair results and no case had poor results. Platlet rich plasma is an excellent method of treatment in early osteoarthritis of knee.

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“…No major complication such as deep infection, muscle atrophy, deep vein thrombosis, fever, hematoma, tissue hypertrophy, adhesion formation, or other major adverse events occurred among study subjects. Similar studies by Sampson S et al [6] , Filardo G et al [7] , Kon E et al [5] , Sun Y et al [8] and Giannini S et al [9] showed no major complication or adverse effects. In our study, three cases in GFRP group showed temporary worsening of pain for about 24 hours which resolved spontaneously.…”

Section: Discussionsupporting

confidence: 63%

Outcome of surgically treated displaced medial epicondyle fracture of humerus in children: A prospective study

Sahu¹,

Ahmad²

2017

Int. J. Orthop. Sci.

0

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Worldwide osteoarthritis is the most common joint disorder. It results from mechanical and biological events that destabilize the normal processes of degradation and synthesis of articular cartilage chondrocytes, extracellular matrix and subchondral bone. These changes include increased water content, decreased proteoglycan content and altered collagen matrix, leading to the degeneration of articular cartilage. There is trend on rise to use platelet rich plasma to promote healing of the degenerated cartilage. The aim of the study was to evaluate whether the newer method i.e platelet rich plasma has any significant advantage. The study included a total of 50 cases with individuals ageing greater than 40 years. Patients without evidence of degenerative arthritis and with KL grade 3 and grade 4 were excluded from the study. At 1 month only 14% cases showed excellent, 68% cases showed and. 18% cases showed fair results. At 3 months follow up 16% cases showed excellent, 82% cases showed good and fair results were seen in 2% cases. No case had poor results. At 6 months follow up 16% cases showed excellent, 86% cases showed good and 6% cases showed fair results and no case had poor results. Platlet rich plasma is an excellent method of treatment in early osteoarthritis of knee.

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“…It can relieve the clinical symptoms in short term and possibly prevent TMJ disease progression in long term. Due to the fact that PRP is a natural source of autologous GFs, it also improves cartilage repairs in degenerative knee pathologic disorder [19,27,28].…”

Section: Resultsmentioning

confidence: 99%

“…Platelets rich plasma (PRP) has recently been used successfully for the treatment of knee degenerative pathologic disorders, because it is safe and has the potential to reduce pain and improve function [18,19].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

Al-Delayme

¹

,

Alnuamy

²

,

Hamid

³

et al. 2016

J. Maxillofac. Oral Surg.

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Objective The objective of this study was to determine average improvement during the rest and active mouth opening after ultrasound guided platelets rich plasma injection in the tempromandibular superior joint space for the patients complaining from non-reducing disk displacement. Patients and Methods Thirty-four patients with non-reducing disk displacement underwent guided ultrasound injection of platelet rich plasma to the upper joint space. The extent of maximal mouth opening, chewing efficiency, sound intensity of the TMJ, and tenderness of the TMJ and the masticatory muscles at rest, motion and mastication were thoroughly assessed at the beginning of the study and scheduled for next follow-up at 1st, 3rd, and 6th months. Results Injection with platelets rich plasma was significantly more effective in improvements of the extent of maximal mouth opening, statistics result demonstrated a significant reduction in the VAS values of pain at rest, motion and mastication compared to the baseline VAS values. Conclusion PRP injection to the upper temporomandibular joint space provided improvement in signs and symptoms of patient with non-reducing disk displacement of the temporomandibular joint.

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Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis

Abstract: The positive trends and safety profile demonstrated could potentially be used to inspire a larger, blinded, and randomized clinical trial to determine whether platelet-rich plasma is safe and effective for the treatment of knee osteoarthritis.

Cited by 279 publications

References 20 publications

Comparative study of static versus dynamic intramedullary nailing of tibia

Comparative study of static versus dynamic intramedullary nailing of tibia

Outcome of surgically treated displaced medial epicondyle fracture of humerus in children: A prospective study

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

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