Injection of intra-articular sodium hyaluronidate (Sinovial®) into the carpometacarpal joint of the thumb (CMC1) in osteoarthritis. A prospective evaluation of efficacy

Roux, Christian; Fontas, Éric; Breuil, Véronique; Brocq, Olivier; Albert, Christine M.; Euller-Ziegler, L.

doi:10.1016/j.jbspin.2006.08.008

Cited by 67 publications

(71 citation statements)

References 11 publications

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“…The use ofNSAIDs was also clearly reduced. These findings are in agreement with the results reported in previous trials (3,(13)(14). Fuchs and Stahls (1), after 3 injections of HA (one/week), observed a significant improvement of symptoms and function after one month, which persisted after 3 and 6 months.…”

Section: Discussionsupporting

confidence: 93%

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Ultrasound-Guided Hyaluronic Acid Injection in Carpometacarpal Osteoarthritis: Short-Term Results

Salini

Amicis

Abate

et al. 2009

Int J Immunopathol Pharmacol

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Section: Discussionsupporting

confidence: 93%

“…The treatment with HA has also been shown useful in CMC-OA, with pain reduction and functional improvement (3,(13)(14)(15). However, few trials have been published and the total number of cases treated is at present scanty.…”

mentioning

confidence: 99%

Ultrasound-Guided Hyaluronic Acid Injection in Carpometacarpal Osteoarthritis: Short-Term Results

Salini

Amicis

Abate

et al. 2009

Int J Immunopathol Pharmacol

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“…In clinical studies, administration of Sinovial Ò resulted in a marked reduction in pain, improvement of joint mobility and decreased use of rescue medication (see later section) [12,24,25]. Importantly, the effects of Sinovial Ò are evident from the first injection (out of a cycle of [3][4][5] and last up to 6 months, suggesting a long-lasting carryover effect of the treatment [12,24,25].…”

Section: Overview Of Sinovial òmentioning

confidence: 99%

“…Importantly, the effects of Sinovial Ò are evident from the first injection (out of a cycle of [3][4][5] and last up to 6 months, suggesting a long-lasting carryover effect of the treatment [12,24,25].…”

Section: Overview Of Sinovial òmentioning

confidence: 99%

The role of intra-articular hyaluronan (Sinovial®) in the treatment of osteoarthritis

2010

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Osteoarthritis (OA) leads to significant pain and disability. For pain relief, a tailored approach using non-pharmacological and pharmacological therapies is recommended. If adequate symptom relief is not achieved with acetaminophen, other pharmacological options include non-steroidal anti-inflammatory drugs (NSAIDs), topical analgesics, intra-articular corticosteroids and intra-articular hyaluronic acid (HA) viscosupplementation. Most of these therapies generally do not improve functional ability or quality of life or are associated with tolerability concerns. In OA patients, concentration and molecular weight (MW) of HA are reduced, diminishing elastoviscosity of the synovial fluid, joint lubrication and shock absorbancy, and possibly anti-inflammatory, analgesic and chondroprotective effects. In knee OA, viscosupplementation with 3-5 weekly intra-articular HA injections diminishes pain and improves disability, generally within 1 week and for up to 3-6 months and is well tolerated. HAs have comparable efficacy as NSAIDs, with less gastrointestinal adverse events, and compared with intra-articular corticosteroids, benefits last generally longer. High MW hylans provide comparable benefits versus HA, albeit with an increased risk of immunogenic adverse events. In mild-to-moderate hip OA, intra-articular injection of HA moderately improved pain and function, generally for up to 3 months with no serious adverse events. Efficacy in other joints is being evaluated. Viscosupplementation with intra-articular Sinovial(®) (other trade names: Yaral(®), Intragel(®)) injections (an HA of low-medium MW) relieves pain and improves function in OA of the knee, and other joints including the carpometacarpal joint of the thumb and the shoulder. HA viscosupplementation, including use of Sinovial(®), is a valuable treatment approach for OA patients, if other therapies are contraindicated or have failed.

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“…Several conservative treatments have been proposed (corticosteroids, non steroidal antiinflammatory drugs, prolotherapy, splinting), but none of these has shown to delay the progression of osteoarthritis or reverse joint damage (Fuchs et al, 2006). In particular, an early improvement in Visual Analogic Scale score was observed after 2 weeks post treatment (Heyworth et al, 2008), with the effects lasting until 1 -3 months (Coaccioli et al, 2006;Roux et al, 2007;Schumacher et al, 2004;Stahl et al, 2005). The long term effects of hyaluronan were demonstrated only in few studies (Fuchs et al, 2006;Heyworth et al, 2008;), in which the pain relief was reported at 6 months (Di Sante et al, 2011).…”

Section: Carpo -Metacarpal Osteoarthritismentioning

confidence: 99%

Hyaluronic Acid in the Treatment of Osteoarthritis: What is New

Abate¹,

Salini²

2012

Osteoarthritis - Diagnosis, Treatment and Surgery

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Injection of intra-articular sodium hyaluronidate (Sinovial®) into the carpometacarpal joint of the thumb (CMC1) in osteoarthritis. A prospective evaluation of efficacy

Cited by 67 publications

References 11 publications

Ultrasound-Guided Hyaluronic Acid Injection in Carpometacarpal Osteoarthritis: Short-Term Results

Ultrasound-Guided Hyaluronic Acid Injection in Carpometacarpal Osteoarthritis: Short-Term Results

The role of intra-articular hyaluronan (Sinovial®) in the treatment of osteoarthritis

Hyaluronic Acid in the Treatment of Osteoarthritis: What is New

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