Injection of botulin toxin into the sphincter of Oddi in patients with acute recurrent pancreatitis: An effective “Medical sphincterotomy”?

Francesco, Vincenzo Di; Bertolasi, Laura; Angelini, G; Bovo, P.; Vaona, B.; Filippini, M; Frulloni, Luca; Grasso, T.; Borsini, G.; Mastromauro, Marina; Rizzuto, Nicolo'; Tebaldi, Morena; Cavallini, Giorgio

doi:10.1016/s0016-5085(98)81830-1

Cited by 3 publications

(1 citation statement)

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“…In this model, they found that ampullary Botox injection led to a trend toward a reduced rate of pancreatic inflammation. In humans, Botox has been used for both diagnostic and therapeutic purposes in recurrent pancreatitis attributed to SOD [18,19]. Intrasphincteric botulinum toxin injection appeared to be safe and effective for reducing attacks of pancreatitis in these limited studies on small numbers of patients.…”

Section: Botulinum Toxin Injection After Biliary Sphincterotomymentioning

confidence: 99%

Botulinum Toxin Injection after Biliary Sphincterotomy

et al. 2004

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Biliary sphincterotomy in patients with sphincter of Oddi dysfunction without pancreatic protection is risky and should no longer be carried out. This study demonstrates that botulinum toxin injection into the residual pancreatic sphincter after biliary sphincterotomy is technically feasible and safe, showing a trend toward a reduced post-ERCP pancreatitis rate in patients with sphincter of Oddi dysfunction. Further studies will need to confirm the validity of these experimental results before this technique can be used routinely.

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Section: Botulinum Toxin Injection After Biliary Sphincterotomymentioning

confidence: 99%

Botulinum Toxin Injection after Biliary Sphincterotomy

et al. 2004

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Botulinum toxin in the therapy of gastrointestinal motility disorders

Gui

Rossi

Runfola

et al. 2003

Aliment Pharmacol Ther

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Summary Since 1980, botulinum toxin has been employed for the treatment of various voluntary muscle spastic disorders in the fields of neurology and ophthalmology. More recently, botulinum toxin has been proved to be effective in the therapy of dyskinetic smooth muscle disorders of the gastrointestinal tract. Achalasia and anal fissure are the gastrointestinal disorders in which botulinum toxin therapy has been most extensively investigated. Botulinum toxin is the best treatment option for achalasia in patients whose condition makes them unfit for pneumatic dilation or surgery. In anal fissure, botulinum toxin is highly effective and may become the treatment of choice. In the future, botulinum toxin application in the gastrointestinal tract will be extended to many other gastrointestinal disorders, such as non‐achalasic motor disorders of the oesophagus, dysfunction of Oddi's sphincter, achalasia of the internal anal sphincter and others. This article describes the mechanism of action, rationale of employment, indications and side‐effects of botulinum toxin application in smooth muscle disorders of the gastrointestinal tract, and compares the results of different techniques of botulinum toxin therapeutic application.

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Botulinum toxin for spastic gastrointestinal disorders

Hoogerwerf

Pasricha

1999

Best Practice & Research Clinical Gastroenterology

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Injection of botulin toxin into the sphincter of Oddi in patients with acute recurrent pancreatitis: An effective “Medical sphincterotomy”?

Cited by 3 publications

References 0 publications

Botulinum Toxin Injection after Biliary Sphincterotomy

Botulinum Toxin Injection after Biliary Sphincterotomy

Botulinum toxin in the therapy of gastrointestinal motility disorders

Botulinum toxin for spastic gastrointestinal disorders

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