Injection of bleomycin as a primary therapy of cystic lymphangioma

Okada, Akira; Kubota, Akio; Fukuzawa, Masahiro; Imura, Kenji; Kamata, Shinkichi

doi:10.1016/0022-3468(92)90331-z

Cited by 128 publications

(93 citation statements)

References 5 publications

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“…Intralesional Bleomycin microsphere in oil-emulsion has reported good response because it is retained for longer period of time. 17, " Report of intralesional aqueous solution of Bleomycin is limited 16,19 In our study, intralesional aqueous solution of Bleomycin has good response in cystic type of lymphangioma as compared to cavernous and other complex lymphangioma 19 . One patient showed complete disappearance after single dose of Bleomycin.…”

Section: Discussionmentioning

confidence: 57%

Non surgical management of cystic lymphangioma

Rawat

Sinha

Kanojia

et al. 2006

Indian J Otolaryngol Head Neck Surg

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Section: Discussionmentioning

confidence: 57%

Non surgical management of cystic lymphangioma

Rawat

Sinha

Kanojia

et al. 2006

Indian J Otolaryngol Head Neck Surg

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“…Niramis et al noted 83% of response whereas Baskin et al noted about 95% of response, suggesting good activity of bleomycin for the purpose. [16][17][18] Two recurrences were seen in this study. The study defined recurrence as the reappearance of the tumour after complete resolution or increase in size after initial significant reduction in size was seen.…”

supporting

confidence: 50%

Ultrasound guided intralesional bleomycin therapy for cystic lymphangioma in childhood

Pan¹

2017

Int J Contemp Pediatr

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Background: Lymphangiomas are benign hamartomatous lymphatic tumors, characterized by multiple communicating lymphatic channels and cystic spaces. They occur in nearly all regions of the body but are most frequently seen in the neck (75%), axilla (20%), and inguinal areas (2%). This study aims to evaluate the effectiveness of intralesional bleomycin sclerotherapy in the treatment of cystic lymphangioma in children and to determine the incidence of complications in the treatment.Methods: This is a prospective study of 36 children diagnosed with cystic lymphangioma and treated with intralesional injection of bleomycin aqueous solution from 2008 to 2015.Results: Complete resolution was seen in (16/36) of lesions, (17/36) had a good response and (3/36) had a poor response. The tumour recurred in 3 patients. No other serious complications or side effects were observed.Conclusions: Intralesional bleomycin therapy was very effective in the treatment of cystic lymphangioma. Our results were comparable to other published studies. Bleomycin administered as intralesional injection was found to be safe as there was no serious complication or side effect observed in this study.

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“…Many adjunctive therapies for treatment of lymphangioma have been described with varying results. Successful outcomes have been reported following the use of intralesional Bleomycin, sclerotherapy with OK432 or percutaneous embolization with Ethibloc [15][16][17] . Local injection of fibrin glue and laser photocoagulation have been used for postnatal treatment 18,19 .…”

Section: Discussionmentioning

confidence: 99%