Injection of baclofen into the ventromedial hypothalamus stimulates gastric motility in the rat

Wood, K. L.; Addae, Jonas I.; Andrews, Paul; Stone, T.W.

doi:10.1016/0028-3908(87)90267-x

Cited by 15 publications

(5 citation statements)

References 16 publications

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“…Baclofen has a marked stimulatory effect on gastric motility and acid secretion in several species, including rats (2), dogs (3) and man (4). Its stimulatory effects were completely abolished by surgical and chemical vagotomy (5)(6)(7)(8). These findings suggest that a muscarinic receptor mechanism participates in these actions of baclofen.…”

Section: Introductionmentioning

confidence: 68%

Effect of selective and non-selective muscarinic blockade on baclofen inhibition of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats

et al. 1996

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The effects of baclofen, a gamma-amino-n-butyric acid receptor B agonist, on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine and how its effects are influenced by selective (M1) and non-selective (M1 and M2) pharmacological blockade of muscarinic receptors were investigated in inbred Wistar rats. Rats were given s.c. injections of 8 mg/kg body wt baclofen with and without 0.5 mg/kg body wt atropine (non-selective M1 and M2 muscarinic receptor antagonist) or 1.0 mg/kg body wt pirenzepine (selective M1 muscarinic receptor antagonist) every other day after a 25 week carcinogen treatment. At week 52 baclofen significantly decreased the incidence of gastric cancers. Concomitant treatment with atropine significantly attenuated the inhibition by baclofen of gastric carcinogenesis, but combined use with pirenzepine had no significant effect on the inhibition by baclofen of gastric carcinogenesis. Baclofen also significantly decreased the labeling index of the antral mucosa. Baclofen plus atropine attenuated the decrease in the labeling index of the antral mucosa due to baclofen, but baclofen plus pirenzepine had no significant effect on the labeling index. These results suggest that the inhibition of gastric carcinogenesis by baclofen is mediated through muscarinic receptors and M2 receptors, but not M1 receptors, are involved in this response.

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Section: Introductionmentioning

confidence: 68%

Effect of selective and non-selective muscarinic blockade on baclofen inhibition of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats

et al. 1996

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“…36 Animal studies have shown that baclofen accentuates gastric tone and increases the frequency and amplitude of gastric and duodenal contractions. [37][38][39][40][41] Human studies have established that baclofen therapy reduces reflux symptoms in patients with reflux disease. [42][43][44][45]3 The histopathology of gastric tissues in group IV only showed superficial mucosal necrosis in the glandular stomach, with edematous sub mucosa as demonstrated in Figure 5(d), while controls and group III rats showed normal gastric histopathology.…”

Section: Resultsmentioning

confidence: 99%

Baclofen systemic toxicity: Experimental histopathological and biochemical study

et al. 2017

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“…Gamma-aminobutyric acid is considered to be an important regulator of gastrointestinal functions in the central nervous system (1)(2)(3)(4)(5). There are some evidence that central ad ministration of GABA agonists and anta gonists caused significant alteration in gastric motility (5,6), gastric secretion (1,7,8) and intestinal electrolyte transport (9). Particu larly, baclofen, a lipophilic derivative of GABA has a marked stimulatory effect on vagal ac tivity, gastric motility and acid secretion in anesthetized rats (2,6,7,(10)(11)(12)(13), conscious dogs (4,14) and humans (15).…”

mentioning

confidence: 99%

“…There are some evidence that central ad ministration of GABA agonists and anta gonists caused significant alteration in gastric motility (5,6), gastric secretion (1,7,8) and intestinal electrolyte transport (9). Particu larly, baclofen, a lipophilic derivative of GABA has a marked stimulatory effect on vagal ac tivity, gastric motility and acid secretion in anesthetized rats (2,6,7,(10)(11)(12)(13), conscious dogs (4,14) and humans (15). These stimula tory effects of baclofen were completely abolished by surgical and chemical vagotomy (6,10,11,14).…”

mentioning

confidence: 99%

“…Particu larly, baclofen, a lipophilic derivative of GABA has a marked stimulatory effect on vagal ac tivity, gastric motility and acid secretion in anesthetized rats (2,6,7,(10)(11)(12)(13), conscious dogs (4,14) and humans (15). These stimula tory effects of baclofen were completely abolished by surgical and chemical vagotomy (6,10,11,14). Furthermore, we have shown that parenteral administration of baclofen induced gastroduodenal ulcers in the anes thetized rat (13).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of GABA antagonists and structural GABA analogues on baclofen stimulated gastric acid secretion in the rat.

Hara

Gotō

1990

Jpn.J.Pharmacol

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Injection of baclofen into the ventromedial hypothalamus stimulates gastric motility in the rat

Cited by 15 publications

References 16 publications

Effect of selective and non-selective muscarinic blockade on baclofen inhibition of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats

Effect of selective and non-selective muscarinic blockade on baclofen inhibition of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats

Baclofen systemic toxicity: Experimental histopathological and biochemical study

Effects of GABA antagonists and structural GABA analogues on baclofen stimulated gastric acid secretion in the rat.

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