Injection laryngoplasty with hyaluronic acid for glottal insufficiency in unilateral vocal fold paralysis: a systematic review of the literature

Švejdová, Anna; Dršata, J; Mejzlík, Jan; Homolac, Michal; Krtickova, Jana; Šatanková, Jana; Chrobok, V

doi:10.1007/s00405-022-07437-0

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…Among the acoustic parameters, CPP was the only statistically significant parameter. This is consistent with the recent studies that present CPP as an important indicator for UVCP [2,5,20]. Aerodynamic parameters are measures of objective voice intensity in patients with UVCP.…”

Section: Discussionsupporting

confidence: 92%

“…Complications are mostly mild such as edema and/or inflammation. Complications can be managed with antibiotics and corticosteroids [5]. This study had several limitations.…”

Section: Discussionmentioning

confidence: 92%

“…Its non-immunogenic nature is attributed to the absence of amino acids [4]. It has very low tissue reactivity and promotes tissue repair and regeneration in vocal cords by providing synthetic building blocks for the extracellular matrix [2,5]. It was initially presented by Hertegård et al [6] in 2002 as an injection material for glottic insufficiency resulting from various causes, including UVCP.…”

Section: Introductionmentioning

confidence: 99%

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The Investigation of Hyaluronic Acid (The Chaeum Premium No.2®) to Evaluate the Efficacy and Safety for Injection Laryngoplasty in Unilateral Vocal Cord Paralysis: A Single Center, Phase II Trial

Park,

Kim

2024

J Korean Soc Laryngol Phoniatr Logop

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Background and Objectives This study aimed to evaluate the clinical efficacy and safety of hyaluronic acid (HA) (The Chaeum Premium No.2®) for injection laryngoplasty (IL) in unilateral vocal cord paralysis (UVCP) patients.Materials and Method This clinical trial has been registered with the clinical research information service of the Republic of Korea (No. KCT0007597). Ten patients with UVCP were enrolled. Auditory-perceptual evaluation, acoustic analysis, aerodynamic analysis, electroglottography, laryngoscopy, and voice handicap index (VHI)-30 were assessed before injection, at 1, 3, and 6 months after injection.Results All auditory-perceptual parameters gradually showed statistically significant improvements at 1, 3, and 6 months after injection. Acoustic, aerodynamic parameters, electroglottography, and VHI-30 showed gradual improvements at 1 and 3 months after injection. Then, they showed slight deterioration 6 months after injection. There were no adverse effects in all patients.Conclusion IL using HA is an effective and safe treatment for UVCP patients.

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Section: Discussionsupporting

confidence: 92%

“…Complications are mostly mild such as edema and/or inflammation. Complications can be managed with antibiotics and corticosteroids [5]. This study had several limitations.…”

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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The Investigation of Hyaluronic Acid (The Chaeum Premium No.2®) to Evaluate the Efficacy and Safety for Injection Laryngoplasty in Unilateral Vocal Cord Paralysis: A Single Center, Phase II Trial

Park,

Kim

2024

J Korean Soc Laryngol Phoniatr Logop

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“…The most important advantage of intracordal HA injection for patients is that it eliminates the risk of aspiration almost immediately after the procedure ( 32 ), thereby reducing the occurrence of pulmonary complication and speed oral diet implementation, which are the most important factors affecting the prognosis after oesophagectomy. In addition, improving voice quality increase satisfaction of patients ( 14 , 33 ). Another advantage is that reabsorption of the injection material is possible ( 14 , 33 ), so it can serve as a bridge before being diagnosed with permanent RLNP and performing other permanent techniques for treatment of RLNP.…”

Section: Discussionmentioning

confidence: 99%

Management for recurrent laryngeal nerve paralysis following oesophagectomy for oesophageal cancer: thoracic surgeon perspective

Lee,

Yun,

Jeong

et al. 2024

J Thorac Dis

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“…Hyaluronic acid comes in small, medium, and large particle gels. Hyaluronic acid injections tend to last for 6–12 months after injection, with the large particle gels lasting longer than the small particle gels 13 . A slight overcorrection of the vocal folds is needed when injecting Hyaluronic acid, and it is best injected lateral to the vocal folds.…”

Section: Treatment Of Small Glottic Gapmentioning

confidence: 99%

Options for treatment of a small glottic gap

Heman‐Ackah

Ivey

Alexander

2023

Laryngoscope Investig Oto

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Background Glottic insufficiency, or glottic gap as it is commonly called, is a common cause of dysphonia, producing symptoms of soft voice, decreased projection, and vocal fatigue. The etiology of glottic gap can occur from issues related to muscle atrophy, neurologic impairment, structural abnormalities, and trauma related causes. Treatment of glottic gap can include surgical and behavioral therapies or a combination of the two. When surgery is chosen, closure of the glottic gap is the primary goal. Options for surgical management include injection medialization, thyroplasty, and other methods of medializing the vocal folds. Methods This manuscript reviews the current literature regarding the options for treatment of glottic gap. Discussion This manuscript discusses options for treatment of glottic gap, including the indications for temporary and permanent treatment modalities; the differences between the available materials for injection medialization laryngoplasty and how they affect the vibratory function of the vocal folds and vocal outcome; and the evidence that supports an algorithm for treatment of glottic gap. Level of Evidence 3a—Systematic review of case–control studies.

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Injection laryngoplasty with hyaluronic acid for glottal insufficiency in unilateral vocal fold paralysis: a systematic review of the literature

Cited by 7 publications

References 22 publications

The Investigation of Hyaluronic Acid (The Chaeum Premium No.2<sup>®</sup>) to Evaluate the Efficacy and Safety for Injection Laryngoplasty in Unilateral Vocal Cord Paralysis: A Single Center, Phase II Trial

The Investigation of Hyaluronic Acid (The Chaeum Premium No.2<sup>®</sup>) to Evaluate the Efficacy and Safety for Injection Laryngoplasty in Unilateral Vocal Cord Paralysis: A Single Center, Phase II Trial

Management for recurrent laryngeal nerve paralysis following oesophagectomy for oesophageal cancer: thoracic surgeon perspective

Options for treatment of a small glottic gap

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