Abstract:Background Countries in Sub-Saharan Africa (SSA) have seen rapid increases in injection drug use since 2008. In Uganda, the Global Sate of Harm report and studies conducted by Makerere University Crane Surveys have estimated HIV prevalence among people who inject drugs (PWID) at approximately 17%. The objective of the research was to document injection and other drug-related risks among people who use drugs in Uganda to develop comprehensive HIV/HCV prevention interventions. Methods Between August and Septembe… Show more
“…The substantial body of evidence on the increased vulnerability of PWID through transactional sex continued to grow. Sex work was reported by 49% of WWID in Kenya [32], 66% in Mexico [52], and the majority of qualitative interview sample in Uganda [53]. Notably, a growing number of studies are reporting the exposure to sex work among men.…”
Purpose of reviewThis review provides a summary of recently published research on sexually transmitted infections (STI) and related behaviors among people who inject drugs (PWID), covering three major areas: sexual behavior and its role in STI transmission among PWID, multilevel factors associated with STI risk, and strategies addressing sexual health of PWID. This review is timely given the growing priority of combination prevention approaches and integrated care for PWID.
Recent findingsModern research improves the understanding that PWID have an increased risk of STI, which varies by gender, setting, type of substance used, and presence of mental disorders. Major socioeconomic and structural factors, specific and nonspecific to PWID, facilitate inequality and sexual risk behavior. Sexual transmission continues to contribute substantially to the spread of bloodborne infections among PWID, accounting for at least 10% of new HIV cases according to epidemiological modeling. Despite the substantial evidence that behavioral interventions can improve sexual health and reduce sex-related risks among PWID, there is a research-practice gap, reflected in the scarcity of implementation studies published recently.
“…The substantial body of evidence on the increased vulnerability of PWID through transactional sex continued to grow. Sex work was reported by 49% of WWID in Kenya [32], 66% in Mexico [52], and the majority of qualitative interview sample in Uganda [53]. Notably, a growing number of studies are reporting the exposure to sex work among men.…”
Purpose of reviewThis review provides a summary of recently published research on sexually transmitted infections (STI) and related behaviors among people who inject drugs (PWID), covering three major areas: sexual behavior and its role in STI transmission among PWID, multilevel factors associated with STI risk, and strategies addressing sexual health of PWID. This review is timely given the growing priority of combination prevention approaches and integrated care for PWID.
Recent findingsModern research improves the understanding that PWID have an increased risk of STI, which varies by gender, setting, type of substance used, and presence of mental disorders. Major socioeconomic and structural factors, specific and nonspecific to PWID, facilitate inequality and sexual risk behavior. Sexual transmission continues to contribute substantially to the spread of bloodborne infections among PWID, accounting for at least 10% of new HIV cases according to epidemiological modeling. Despite the substantial evidence that behavioral interventions can improve sexual health and reduce sex-related risks among PWID, there is a research-practice gap, reflected in the scarcity of implementation studies published recently.
“…HIV/ AIDS is one of the most prevalent conditions in Uganda, with 6.7% of adults living with HIV in Uganda. 9 However, its accurate diagnosis was rare in the late 1990s and the early 2000, and with minimal or no attention paid to psychiatric complications of HIV at the time, 10 thus, more deaths occurred in 2002.…”
Background: There is higher global mortality among persons living with mental illness than the general population, attributed to the risky behaviours associated with mental illness, medical comorbidities, or side effects of psychiatric medications that result in premature death among psychiatric in patients. Objective: This audit aimed to describe the characteristics of patients with mental illness who died during admission at a tertiary psychiatric ward in Uganda. Methods: This was a retrospective chart review of patients who died while admitted to a psychiatry ward between January 1995 to July 2020. Results: We reviewed 30 charts, of which 18 (60%) patients were women. The majority of patients died during 2002 (13.3%). Many were diagnosed with a brief psychotic disorder, 7 (23.3%), followed by bipolar disorder 6 (20.0%). HIV and epilepsy were the most common comorbidities. The majority of the death causes of death were unknown, 20 (66.7), but heart attack (n=2) was the most identified cause.
Conclusion:The majority of the causes of mortality were unknown. The most common cause of mortality was heart attack, a common effect of metabolic disease and chronic antipsychotic use. Mortality audits are warranted to identify possible causes and to develop strategic interventions for mortality prevention.
“…Drug markets have expanded west, and Uganda has experienced increasing numbers of people who use and inject drugs (PWUD and PWID, respectively) [ 14 , 15 , 16 , 17 ]. HIV prevalence among PWID in Uganda is estimated to be around 17% in multiple studies [ 14 , 17 ], with heroin being the most commonly injected drug among over 70% of PWID [ 18 ]. Further, most women who inject drugs also exchange sex for money or drugs, begin injecting earlier, and their HIV prevalence is likely even higher [ 18 ].…”
Section: Introductionmentioning
confidence: 99%
“…HIV prevalence among PWID in Uganda is estimated to be around 17% in multiple studies [ 14 , 17 ], with heroin being the most commonly injected drug among over 70% of PWID [ 18 ]. Further, most women who inject drugs also exchange sex for money or drugs, begin injecting earlier, and their HIV prevalence is likely even higher [ 18 ]. There are no current estimates of HCV infection as testing is not routinely done in Uganda, although HCV rates are high in other East African countries [ 13 ].…”
Background: Although Africa has long borne the brunt of the human immunodeficiency virus (HIV) epidemic, until recently, the continent has been considered largely free of illicit drug use and injection drug use in particular. In Uganda, the number of people who use or inject drugs (PWUD and PWID, respectively) has increased, and PWID are a key population at high risk for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection. However, harm reduction practices, including providing clean injection equipment and medication-assisted treatment (MAT), have only recently been piloted in the country. This project aims to integrate buprenorphine into a harm reduction drop-in center (DIC). Methods: The Consolidated Framework for Implementation Research was used to guide our preparations to integrate buprenorphine into existing practices at a harm reduction DIC. We conducted key informant interviews with members of a community advisory board and DIC staff to document this process, its successes, and its failures. Results: Results indicate that criminalization of drug use and stigmatization of PWUD challenged efforts to provide buprenorphine treatment in less regulated community settings. Conclusions: DIC staff and their commitment to harm reduction and advocacy facilitated the process of obtaining necessary approvals.
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