Injectable Sustained-Release Depots of PLGA Microspheres for Insoluble Drugs Prepared by hot-Melt Extrusion

Guo, Yuting; Yang, Yunning; He, Luying; Sun, Rong; Pu, Chenguang; Xie, Bin; He, Huan; Yin, Tian; Wang, Yanjiao

doi:10.1007/s11095-017-2228-x

Cited by 25 publications

(14 citation statements)

References 33 publications

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“…In fact, it is possible to produce injectable MP depots by coupling HME with micronization methods, such as wet milling or jet-milling in order to obtain spherical particles (Nykamp et al 2002;Guo et al 2017b). HME is a costeffective method characterized by the absence of an organic solvent, continuous operation, and easy scale up.…”

Section: Hot-melt Extrusionmentioning

confidence: 99%

Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing

Schoubben

Ricci

Giovagnoli

2019

J. Pharm. Investig.

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Background Polylactides (PLA) and poly lactide-co-glycolides (PLGA) undoubtedly are among the major drivers in the pharmaceutical market. Their relevance in pharmaceutics and biomedicine is well established in light of their sustainability, safety, tunable biodegradability, and versatility. However, polymer degradability and plasticity can somehow restrain industrial developability of PLA and PLGA formulations, especially in the form of microparticles (MP). Area covered This review wants to deal with the known manufacturing issues of PLA/PLGA MP, debating the potential contribution of modern and cutting-edge manufacturing technologies to the solution of unmet production needs. Technological and regulatory aspects will be considered outlining the potential role of advanced manufacturing techniques in the advancement of PLA/PLGA MP production processes. Expert opinion The multifaceted complexity of PLA/PLGA MP manufacturing processes demands adequate standardization and updated guidelines covering the so far unmet industrialization requirements. Novel and evolving manufacturing technologies will surely support the future development of bench-to-production plant transfer for such products. Careful evaluation of production costs is demanded in order to ensure process sustainability and patient's outreach.

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Section: Hot-melt Extrusionmentioning

confidence: 99%

Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing

Schoubben

Ricci

Giovagnoli

2019

J. Pharm. Investig.

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“…PLGA/PLA microspheres are prepared by this method without using any organic solvent. As no organic solvent is evaporated from dosage forms hence no pores are developed during solidification and drug encapsulation is 100% theoretically (30) . Alorgan Inc. using hot extrusion method developed an implant containing dexamethasone with PLGA as intravitreal injection.…”

Section: Organic Phase Separationmentioning

confidence: 99%

A Review on New Trends in Preparation of Long Acting Microspheres

Pathak¹,

Paliwal²

2019

J. Drug Delivery Ther.

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The Purpose of designing sustained or controlled delivery systems has always been to bring down the dose frequency that offers better patient compliance & reduced side effects Microspheres have shown to reduce the dose, side effects, frequency of administration and possibility of dose dumping, therefore increased patient compliance. There are several methods of preparation for microspheres, slight variation in basic method can produce numerous changes in final outcome. However various problems are still not resolved with these methods like wide size distribution & poor repeatability. Biodegradation rate of the microspheres in controlled by the composition of the microspheres and consecutively affects the release profile of drug, i.e. PGA, PLA and PCL have hydrolytic degradation role in order of PGA>PLA>>PCL. Keywords: controlled delivery, microspheres, patient compliance

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“…The carrier particles should be large enough (about 10 μm or more) to stay in the deposition site. This mechanism enables sustainable drug delivery during time controlled by microparticle degradation or drug diffusion from it [ 16 , 17 , 18 , 19 , 20 , 21 ]. The second mechanism requires small nanoparticles (with diameters usually lower than 100 nm), which together with their drug payload aggregate upon injection or when injected are suspended in a substance-forming gel in situ [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Reactions leading to functionalization of mesoporous silica nanoparticles (MSN-NH2) with PEG linker, followed by aza-dibenzocyclooctyne (DBCO) coupling. The reaction between DBCO-PEG-MSNs and18 F-labelled azide occurs under physiological-like conditions. The MSNs labeled with18 F were prepared for PET imaging.…”

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confidence: 99%

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Functionalized Particles Designed for Targeted Delivery

et al. 2021

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Pure bioactive compounds alone can only be exceptionally administered in medical treatment. Usually, drugs are produced as various forms of active compounds and auxiliary substances, combinations assuring the desired healing functions. One of the important drug forms is represented by a combination of active substances and particle-shaped polymer in the nano- or micrometer size range. The review describes recent progress in this field balanced with basic information. After a brief introduction, the paper presents a concise overview of polymers used as components of nano- and microparticle drug carriers. Thereafter, progress in direct synthesis of polymer particles with functional groups is discussed. A section is devoted to formation of particles by self-assembly of homo- and copolymer-bearing functional groups. Special attention is focused on modification of the primary functional groups introduced during particle preparation, including introduction of ligands promoting anchorage of particles onto the chosen living cell types by interactions with specific receptors present in cell membranes. Particular attention is focused on progress in methods suitable for preparation of particles loaded with bioactive substances. The review ends with a brief discussion of the still not answered questions and unsolved problems.

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Injectable Sustained-Release Depots of PLGA Microspheres for Insoluble Drugs Prepared by hot-Melt Extrusion

Abstract: Microspheres prepared by HME combined with wet-milling could achieve a long-term sustained release effect as a novel long-acting formulation strategy.

Cited by 25 publications

References 33 publications

Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing

Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing

A Review on New Trends in Preparation of Long Acting Microspheres

Functionalized Particles Designed for Targeted Delivery

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