Injectable Superparamagnetic Ferrogels for Controlled Release of Hydrophobic Drugs

Qin, Jian; Asempah, Isaac; Laurent, Sophie; Fornara, Andrea; Müller, Robert N.; Muhammed, Mamoun

doi:10.1002/adma.200800764

Cited by 158 publications

(135 citation statements)

References 51 publications

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“…Peptides containing the arginine-glycine-aspartic acid (RGD) amino acid sequence, a ubiquitous cell-binding domain found in many extracellular matrix molecules, were covalently coupled to the alginate. Iron oxide particles with diameters ∼10 nm were embedded in the alginate, which results in a superparamagnetic gel (39). Macroporous structures with interconnected pores in the micrometer range were generated from the gels.…”

mentioning

confidence: 99%

“…Recent studies have shown controlled release of a number of drugs from ferrogels subject to magnetic fields (32)(33)(34)(35)(36)(37). Ferrogels have also been made biodegradable (38) and injectable (39). However, typical ferrogels for drug delivery demonstrate very limited deformation and volumetric change, and the pore sizes in most ferrogels are in the nanometer range (36), which limits transport of large molecules and cells through the gels.…”

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confidence: 99%

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Active scaffolds for on-demand drug and cell delivery

Zhao

Kim

Cezar

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

591

472

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Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external regulation. We present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. The active porous scaffold, in the form of a macroporous ferrogel, gives a large deformation and volume change of over 70% under a moderate magnetic field. The deformation and volume variation allows a new mechanism to trigger and enhance the release of various drugs including mitoxantrone, plasmid DNA, and a chemokine from the scaffold. The porous scaffold can also act as a depot of various cells, whose release can be controlled by external magnetic fields.

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mentioning

confidence: 99%

mentioning

confidence: 99%

Active scaffolds for on-demand drug and cell delivery

Zhao

Kim

Cezar

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

591

472

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“…[630] However, since ferrogels have an intrinsically hydrophilic nature, most of these studies are focused only on water-soluble drug. In this matter, a pioneering study performed by Qin et al [631] addressed the problem of effective incorporation of important hydrophobic drugs in ferrogels by employing Pluronic-F127 micelles encapsulating SPIONs. In fact, in addition to proper biocompatibility, high stability, and low toxicity features, [632] Pluronic copolymers could associate into micelles via hydrophobic interactions above a certain critical concentration and temperature.…”

Section: Magnetic Drug Targetingmentioning

confidence: 99%

“…Reproduced with permission. [631] www.advancedsciencenews.com www.advhealthmat.de on magnetic tumor targeting in CT26 tumor-bearing mice (Figures 39a,b). It was shown that uptake in tumors exposed to magnetic field (TU+) is significantly higher compared to that of unexposed (TU−) (Figure 39c).…”

Section: Magnetic Drug Targetingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

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192

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…Lin, Watanabe, Kimura, Hanabusa, & Shirai, 2003;Mitsumata et al, 1999;Resendiz-Hernandez, Rodriguez-Fernandez, & GarciaCerda, 2008;Szabo, Czako-Nagy, Zrinyi, & Vertes, 2000;Zrinyi, Barsi, & Buki, 1997), and their derivative copolymers (C. L. Lin, Chiu, & Don, 2006). Also prevalent are gelatin (Saslawski, Weingarten, Benoit, & Couvreur, 1988) and copolymers of polyethylene oxide (Qin et al, 2009;Wormuth, 2001). Significantly less attention has been given to hydrophobic magnetic elastomers, which include a few instances of polydimethylsiloxane (Evans et al, 2007;Jolly, Carlson, Munoz, & Bullions, 1996;Varga, Feher, Filipcsei, & Zrinyi, 2003) and polystyrene (Timonen et al, 2010).…”

Section: Polymer Candidatesmentioning

confidence: 99%