Injectable stretchable self-healing dual dynamic network hydrogel as adhesive anti-oxidant wound dressing for photothermal clearance of bacteria and promoting wound healing of MRSA infected motion wounds

Li, Meng; Liang, Yongping; Liang, Yuqing; Pan, Guoying; Guo, Baolin

doi:10.1016/j.cej.2021.132039

Cited by 172 publications

(123 citation statements)

References 56 publications

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“…PTT is a kind of artificial increasing of tissue temperature with the contribution of PHTAs that can absorb light and convert it into heat to cause the denaturation of protein, the cavitation and rupture of cells, the formation of bubbles, and the fragmentation of DNA, leading to the thermal ablation of the undesired cells at the target site to achieve a good therapeutic effect. − Based on high inherent specificity and low invasive burden, PTT is an attractive and promising local heating approach which can accelerate the blood flow in the wound area, while stimulating the proliferation of fibroblasts and reducing inflammation, thereby accelerating the wound healing process. − …”

Section: Photothermal Therapymentioning

confidence: 99%

Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

et al. 2021

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Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic therapy (PDT) show great application prospects in the prevention of wound infection and promoting wound healing. In addition, hydrogels have shown attractive advantages in the field of wound dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive hydrogels (MPRHs) that integrate the advantages of light and hydrogels are increasingly used in biomedicine, especially in the field of wound repair. However, a comprehensive review of MPRHs for wound regeneration is still lacking. This review first focuses on various types of MPRHs prepared by diverse photosensitizers, photothermal agents (PHTAs) including transition metal sulfide/oxides nanomaterials, metal nanostructure-based PHTAs, carbon-based PHTAs, conjugated polymer or complex-based PHTAs, and/or photodynamic agents (PHDAs) such as ZnO-based, black-phosphorus-based, TiO 2 -based, and small organic molecule-based PHDAs. We also then discuss how PTT, PDT, and photothermal/photodynamic synergistic therapy can modulate the microenvironments of bacteria to inhibit infection. Overall, multifunctional hydrogels with both therapeutic and tissue regeneration capabilities have been discussed and existing challenges, as well as future research directions in the field of MPRHs and their application in wound management are argued.

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Section: Photothermal Therapymentioning

confidence: 99%

Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

et al. 2021

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“… 4 Exposure, ischaemia and dehydration often damage the microenvironment of the wound site and interfere with the healing process, particularly in large‐scale and chronic wounds. 5 , 6 In addition, due to the absence of a series of specific molecular and cellular processes in the healing process, chronic wounds in diabetic patients take a long time to heal. 7 , 8 Therefore, for effective wound healing, an appropriate microenvironment and supplementation with growth factors can ameliorate the local microenvironment in diabetic ulcer patients, promoting skin regeneration and functional restoration.…”

Section: Introductionmentioning

confidence: 99%

Functional extracellular matrix hydrogel modified with MSC‐derived small extracellular vesicles for chronic wound healing

et al. 2022

Cell Proliferation

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Objectives Diabetic wound healing remains a global challenge in the clinic and in research. However, the current medical dressings are difficult to meet the demands. The primary goal of this study was to fabricate a functional hydrogel wound dressing that can provide an appropriate microenvironment and supplementation with growth factors to promote skin regeneration and functional restoration in diabetic wounds. Materials and Methods Small extracellular vesicles (sEVs) were bound to the porcine small intestinal submucosa‐based hydrogel material through peptides (SC‐Ps‐sEVs) to increase the content and achieve a sustained release. NIH3T3 cell was used to evaluate the biocompatibility and the promoting proliferation, migration and adhesion abilities of the SC‐Ps‐sEVs. EA.hy926 cell was used to evaluate the stimulating angiogenesis of SC‐Ps‐sEVs. The diabetic wound model was used to investigate the function/role of SC‐Ps‐sEVs hydrogel in promoting wound healing. Results A functional hydrogel wound dressing with good mechanical properties, excellent biocompatibility and superior stimulating angiogenesis capacity was designed and facilely fabricated, which could effectively enable full‐thickness skin wounds healing in diabetic rat model. Conclusions This work led to the development of SIS, which shows an unprecedented combination of mechanical, biological and wound healing properties. This functional hydrogel wound dressing may find broad utility in the field of regenerative medicine and may be similarly useful in the treatment of wounds in epithelial tissues, such as the intestine, lung and liver.

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“…Previous works have reported diverse strategies for the preparation of multifunction adhesive hydrogels, including chemical anchorage, physical adhesion, mechanical interlocking and bio-inspired means ( Karami et al, 2018 ; Yang et al, 2018 ). Physical adhesion interactions, like hydrogen bonds, electrostatic and hydrophobic interactions, at the interface between the hydrogel and substrate were studied due to their multipurpose and reusable abilities ( Xing et al, 2021 ; Li et al, 2022 ). For example, Guo developed adhesive hydrogels based on derivatives of hyaluronic acid, poly (ethylene glycol)- co -poly (glycerol sebacate) and cuttlefish melanin nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…For example, Guo developed adhesive hydrogels based on derivatives of hyaluronic acid, poly (ethylene glycol)- co -poly (glycerol sebacate) and cuttlefish melanin nanoparticles. The amino and catechol groups formed multiple interactions with tissue, which enabled the attachment to the skin surface to be maintained ( Li et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic

Xiao

et al. 2022

Front. Bioeng. Biotechnol.

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Hydrogels with adhesive properties have the potential for rapid haemostasis and wound healing in uncontrolled non-pressurized surface bleeding. Herein, a typical hydrogen bond-crosslinked hydrogel with the above functions was constructed by directly mixing solutions of humic acid (HA) and polyvinylpyrrolidone (PVP), in which the HA worked as a crosslinking agent to form hydrogen bonds with the PVP. By altering the concentration of HA, a cluster of stable and uniform hydrogels were prepared within 10 s. The dynamic and reversible nature of the hydrogen bonds gave the HA/PVP complex (HPC) hydrogels injectability and good flexibility, as well as a self-healing ability. Moreover, the numerous functional groups in the hydrogels enhanced the cohesion strength and interaction on the interface between the hydrogel and the substrate, endowing them with good adhesion properties. The unique chemical composition and cross-linking mechanism gave the HPC hydrogel good biocompatibility. Taking advantage of all these features, the HPC hydrogels obtained in this work were broadly applied as haemostatic agents and showed a good therapeutic effect. This work might lead to an improvement in the development of multifunctional non-covalent hydrogels for application to biomaterials.

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Injectable stretchable self-healing dual dynamic network hydrogel as adhesive anti-oxidant wound dressing for photothermal clearance of bacteria and promoting wound healing of MRSA infected motion wounds

Cited by 172 publications

References 56 publications

Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

Functional extracellular matrix hydrogel modified with MSC‐derived small extracellular vesicles for chronic wound healing

A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic

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