Injectable Skin Fillers

Narins, Rhoda S.; Bowman, Paul H.

doi:10.1016/j.cps.2004.12.002

Cited by 113 publications

(101 citation statements)

References 22 publications

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“…Hypersensitivity skin reactions to injectable fillers can be mild, but cases of severe anaphylactic shocks due to the filler substance has been reported previously [31,36]. Delayed hypersensitivity to the injected product can occur with cosmetic devices and may arise several months or years after injection [41]. The risk for allergic reaction is highly dependent on the filler material itself.…”

Section: Material-independent Adverse Eventsmentioning

confidence: 99%

Critical Appraisal of the Safety of Dermal Fillers: A Primer for Clinicians

Luebberding

Alexiades-Armenakas

2013

Curr Derm Rep

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Injectable cosmetic wrinkle fillers are soft-tissue fillers approved as medical devices by the U.S. Food and Drug Administration (FDA). These devices are injected into the skin for correcting soft-tissue contour defects, such as moderate and severe wrinkles and folds, and for restoring the signs of facial fat loss in people with human immunodeficiency virus. Although the aesthetic treatment with injectable dermal fillers is considered to be safe, adverse events are involved with this minimally-invasive treatment. The FDA received 930 post-marked reports of adverse event from 2003 through 2008, of which 823 were deemed severe and 638 required medical treatment and follow-up.

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Section: Material-independent Adverse Eventsmentioning

confidence: 99%

Critical Appraisal of the Safety of Dermal Fillers: A Primer for Clinicians

Luebberding

Alexiades-Armenakas

2013

Curr Derm Rep

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“…Previous studies have shown that Macrolane remains in the breast up to 18 months after injection with volumes of 80 mL to 100 mL per breast (16)(17)(18)(19)(20). Because the surgeons in the current study only injected 30 mL to 40 mL per breast, on average, a similar comparison is not possible.…”

Section: Early Degradation Of Gelmentioning

confidence: 45%

Complications and management of breast enhancement using hyaluronic acid

Ishii¹,

Sakata²

2014

CAN J PLAST SURG

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“…Knowledge of different characteristics and limitations of injectable permanent tissue fillers, as well as training in specific injection techniques, have been reported; a necessary requirement to help a plastic surgeon to reduce the risk of complications and to increase the safe use of the product [2,15,30,206].…”

Section: Clinical Data On Injectable Tissue Fillers: a Reviewmentioning

confidence: 99%

“…Although product as well as treatment related complications have been described in more than onethird of the studies, no specifications of the causes of the complications were given. Although this category of products is associated with an apparently minimal or low incidence of severe complications, knowledge of the product characteristics and training in specific injection techniques are necessary for the safe use of the products [2,15,30,204].…”

Section: Semi-permanent Tissue Fillersmentioning

confidence: 99%

“…Adverse side effects can be caused by incorrect injection techniques (treatment related) or by the characteristics of the products (product related) [11,12]. Short-, mid-and long-term complications can be discerned (TABLE 1) [2,[13][14][15]. Short-term complications like pain, swelling, fever, immediate hypersensitivity reactions, occur immediately or within several days past treatment and disappear after several weeks.…”

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confidence: 99%

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Clinical data on injectable tissue fillers: a review

Vries

Geertsma

2013

Expert Review of Medical Devices

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Treatment with injectable tissue fillers for aesthetic purposes is increasingly popular. In parallel with this success, questions related to the safety of these treatments and the products involved are being raised more prominently. To gain insight in the safety aspects of injectable tissue fillers, we performed a literature review to collect studies reporting clinical data of injectable tissue fillers. We found several case reports where serious complications after more than three years are described. However, there are only a limited number of well-defined prospective clinical studies available with follow-up periods longer than three years. Furthermore, causes of complications, that is, treatment or product related, are often not specified in literature. Considering the intended functional period of fillers in combination with the known occurrence of long-term complications, there is a need for well-defined prospective clinical studies. In order to be able to discriminate between product failure (a product safety issue) or application methodology (a physician expertise or training issue), better identification of observed complications and whether they are product or treatment related, is needed. For the safe use of the fillers it is important that treatment with injectable tissue fillers is performed by a trained physician, who knows the product specifications and its applications. . Moreover, it is expected that due to increase in life expectancy, the demand for anti-aging treatments, like tissue augmentation with injectable tissue fillers, will grow [2]. Their success has been attributed to the fact that treatments with injectable tissue fillers are fast and appear to be relatively easy [2]. Only a relatively 'simple' subcutaneous injection is needed. Today, various injectable tissue fillers with different characteristics are available, for example, duration of the effect, material type and intended anatomical location.Although the application of an injectable tissue filler seems to be relatively simple and safe, reports of serious adverse effects have appeared in the literature [2][3][4][5][6][7][8]. Estimates of the occurrence of severe complications after treatment with various types of injectable tissue fillers range between 1:80 and 1:50,000 patients [9,10]. Adverse side effects can be caused by incorrect injection techniques (treatment related) or by the characteristics of the products (product related) [11,12]. Short-, mid-and long-term complications can be discerned (TABLE 1) [2,13-15]. Short-term complications like pain, swelling, fever, immediate hypersensitivity reactions, occur immediately or within several days past treatment and disappear after several weeks. A more severe short-term complication is necrosis [5,16]. Necrosis occurs immediately or within a few days if blood vessels are obstructed by the filler material or if they are injured during the treatment [17]. Mid-term complications such as delayed inflammatory reactions, ulceration and granuloma reaction may occur after 2-12 months. I...

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Injectable Skin Fillers

Cited by 113 publications

References 22 publications

Critical Appraisal of the Safety of Dermal Fillers: A Primer for Clinicians

Critical Appraisal of the Safety of Dermal Fillers: A Primer for Clinicians

Complications and management of breast enhancement using hyaluronic acid

Clinical data on injectable tissue fillers: a review

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