Injectable Self‐Healing Antibacterial Bioactive Polypeptide‐Based Hybrid Nanosystems for Efficiently Treating Multidrug Resistant Infection, Skin‐Tumor Therapy, and Enhancing Wound Healing

Abstract

The surgical procedure in skin-tumor therapy usually results in cutaneous defects, and multidrug-resistant bacterial infection could cause chronic wounds. Here, for the first time, an injectable self-healing antibacterial bioactive polypeptide-based hybrid nanosystem is developed for treating multidrug resistant infection, skin-tumor therapy, and wound healing. The multifunctional hydrogel is successfully prepared through incorporating monodispersed polydopamine functionalized bioactive glass nanoparticles (BGN@ PDA) into an antibacterial F127-ε-Poly-L-lysine hydrogel. The nanocomposites hydrogel displays excellent self-healing and injectable ability, as well as robust antibacterial activity, especially against multidrug-resistant bacteria in vitro and in vivo. The nanocomposites hydrogel also demonstrates outstanding photothermal performance with (near-infrared laser irradiation) NIR irradiation, which could effectively kill the tumor cell (>90%) and inhibit tumor growth (inhibition rate up to 94%) in a subcutaneous skin-tumor model. In addition, the nanocomposites hydrogel effectively accelerates wound healing in vivo. These results suggest that the BGN-based nanocomposite hydrogel is a promising candidate for skin-tumor therapy, wound healing, and antiinfection. This work may offer a facile strategy to prepare multifunctional bioactive hydrogels for simultaneous tumor therapy, tissue regeneration, and anti-infection.

Recent Development of Polydopamine Anti-Bacterial Nanomaterials

“…Similarly, Fu's group [98] also adopted this strategy as they modified PDA with an antimicrobial peptide, magainin I, which can interact with bacteria and cause significant bacterial death under near-infrared irradiation. In addition, Lei et al [99] developed a multifunctional bioactive nanocomposite hydrogel with self-healing and antibacterial capabilities based on a bioactive polypeptide (Figure 7b1). The multifunctional hydrogel was prepared by incorporating PDA-functionalized bioactive glass nanoparticles into F127-ε-poly-L-lysine hydrogel, which not only exhibited superior self-healing and injectable properties, but also robust antibacterial ability, especially against multidrugresistant bacteria associated with skin tumors and wound healing (Figure 7b2).…”

Integrated Copper Nanomaterials‐Decorated Microsphere Photothermal Platform for Comprehensive Melanoma Treatment

“…[2] However, these treatments often result in incomplete tumor removal, limited efficacy of chemotherapeutic drugs, and the development of full-thickness skin defects, leading to tumor recurrence, metastasis, and an increased risk of infection or chronic wounds. [3][4][5] Antibiotics are commonly used to treat bacterial infections, but the growing prevalence of antibiotic resistance poses a challenge. [6,7] Furthermore, radiation dermatitis, a common side effect of radiotherapy characterized by reactive oxygen species (ROS) production and inflammation, significantly affects the quality of life of patients and lacks effective treatment options.…”