Injectable, self-healing and pH responsive stem cell factor loaded collagen hydrogel as a dynamic bioadhesive dressing for diabetic wound repair

Zhang, Li; Zhou, Yuting; Su, Dandan; Wu, Shuying; Zhou, Juan; Chen, Jinghua

doi:10.1039/d1tb01163d

Cited by 38 publications

(35 citation statements)

References 33 publications

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“…Therefore, the wounded area pH has become crucial in formulating target-specific and stimuli-responsive hydrogels. Compared to native pH, the wound fluid remains acidic due to the release of organic acids and microbial infection [ [157] , [158] , [159] , [160] ].…”

Section: Films Scaffolds and Hydrogelsmentioning

confidence: 99%

Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens

Sathishkumar

Kasi²,

He³

et al. 2023

Bioactive Materials

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Section: Films Scaffolds and Hydrogelsmentioning

confidence: 99%

Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens

Sathishkumar

Kasi²,

He³

et al. 2023

Bioactive Materials

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“…Sericin is a polymer biomaterial with excellent biocompatibility and is mainly used as a wound dressing [ 16–18 ]. Zhang et al [ 19 ] found that sericin hydrogel combined with stem cell factors can effectively generate blood vessels and promote collagen deposition. The crosslinking of the porosity of sericin materials can encapsulate growth factors for drug delivery [ 20–22 ].…”

Section: Introductionmentioning

confidence: 99%

Genetically engineered FGF1-sericin hydrogel material treats intrauterine adhesion and restores fertility in rat

Guan

Wang

Zhang

et al. 2022

Regenerative Biomaterials

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Endometrial injury can cause intrauterine adhesions (IUA) and induce the formation of endometrial fibrosis, leading to infertility and miscarriage. At present, there is no effective treatment method for severe IUA and uterine basal injury with adhesion area larger than 1/3 of the uterus. In this study, we prepared FGF1 silk sericin hydrogel material (FGF1-SS hydrogel) to treat endometrial injury and prevent endometrial fibrosis. Compared with the silk sericin hydrogel material (WT-SS hydrogel), FGF1-SS hydrogel significantly promotes the cell migration and infiltration ability of endometrial stromal cells (ESCs). More importantly, FGF1-SS hydrogel can release FGF1 stably for a long time and inhibit The ESCs injury model forms fibrosis through the TGF-β/Smad pathway. In the IUA rat model, FGF1-SS hydrogel treatment effectively restored the number of uterine glands and uterine wall thickness in rats, with a fertility rate of 65.1 ± 6.4%. The results show that FGF1-SS hydrogel is expected to be a candidate to prevent IUA.

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“…prepared umbilical cord stem cell factor (SCF)‐loaded collagen/polyethylene glycol (Col/APG@SCF) hydrogels. [ 144 ] Compared with noncytokine hydrogels, Col/APG@SCF hydrogels could inhibit proinflammatory cytokine TNF‐a expression and promote macrophage to M2 phenotype polarization.…”

Section: Hydrogels For Wound Healingmentioning

confidence: 99%

Progress in Hydrogels for Skin Wound Repair

Zhang

Wang

et al. 2022

Macromolecular Bioscience

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As the first defensive line between the human body and the outside world, the skin is vulnerable to damage from the external environment. Skin wounds can be divided into acute wounds (mechanical injuries, chemical injuries, and surgical wounds, etc.) and chronic wounds (burns, infections, diabetes, etc.). In order to manage skin wound, a variety of wound dressings have been developed, including gauze, films, foams, nanofibers, hydrocolloids, and hydrogels. Recently, hydrogels have received much attention because of their natural extracellular matrix (ECM)‐mimik structure, tunable mechanical properties, and facile bioactive substance delivery capability. They show great potential application in skin wound repair. This paper first introduces the anatomy and function of the skin, the process of wound healing and conventional wound dressings, and then introduces the composition and construction methods of hydrogels. Next, this paper introduces the necessary properties of hydrogels in skin wound repair and the latest research progress of hydrogel dressings for skin wound repair. Finally, the future development goals of hydrogel materials in the field of wound healing are proposed.

show abstract

Injectable, self-healing and pH responsive stem cell factor loaded collagen hydrogel as a dynamic bioadhesive dressing for diabetic wound repair

Abstract: As one of the serious complications of diabetes, diabetic ulcer induces several clinical problems. Although a variety of wound dressing are commonly employed, their role is too simple to integrate...

Cited by 38 publications

References 33 publications

Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens

Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens

Genetically engineered FGF1-sericin hydrogel material treats intrauterine adhesion and restores fertility in rat

Progress in Hydrogels for Skin Wound Repair

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