Injectable Scaffolds for In Vivo Programmed Macrophages Manufacture and Postoperative Cancer Immunotherapy

Wu, Xiaodan; Zhong, Zhenyu; Li, Yan; Wang, Yifan; Tian, Yaping; Liu, Xulong; Zhang, Xin; Tao, Weiyong; Wang, Jianglin; Du, Yingying; Zhang, Shengmin

doi:10.1002/adfm.202300058

Cited by 8 publications

(2 citation statements)

References 51 publications

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“…Apart from enhancing macrophage phagocytosis of tumor cells, blocking CD47 may also increase macrophage recruitment to tumor cells. However, blocking CD47 can transform TAMs into antitumor state and enable more macrophages to recruit to the tumor [ 51 , 52 ]. Therefore, prostate cancer may be treated with tumor treatments that target CD47.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Wang,

Feng,

Chen

et al. 2023

Journal of Immunology Research

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Background. CD47 has high levels of expression in malignant cancer cells, which binds to SIRP-α to release the “don’t eat me” signal and prevents mononuclear macrophages from phagocytosing the cells. Resistance to drugs and metastases are potential barriers for prostate cancer endocrine therapy. Although immunotherapy for tumors has developed rapidly in the last few decades, its effectiveness in treating prostate cancer is unsatisfactory. Prostate cancer has a high-expression level of CD47. Therefore, a novel approach for potential immunotherapy may be provided by investigating the relationship among CD47 and the infiltration of immune cells in the prostate carcinoma. Methods. The GEPIA database was utilized to compare the abundance of CD47 in malignant tissues with tissues that were normal. Furthermore, the function of CD47 in prostate carcinoma was assessed by CancerSEA. The association among CD47 and the tumor microenvironment was assessed utilizing the TISCH single cell data database. By using TIMER, the connection among CD47 and immunological invasion of prostate cancer was explored. Moreover, macrophages were cocultured with mouse prostate cancer cell RM-1 blocked by CD47 antibody to observe the changes in phagocytosis efficiency in vitro. Results. Expression level of CD47 is upregulated in prostate carcinoma, and it is closely connected with prostate cancer’s inadequate immune invasion. CD47 antibody blocking promotes macrophage phagocytosis of RM-1. Conclusion. Our research demonstrates a closely relationship among CD47 and the immunological microenvironment of prostate cancer, and blocking CD47 can promote macrophages to phagocytosis of prostate cancer cells. Therefore, CD47 may provide novel strategies for potential immunotherapy of prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Wang,

Feng,

Chen

et al. 2023

Journal of Immunology Research

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“…The hydrogel recruited intrinsic macrophages and released V-M1EM-aCD47 which was capable of reprogramming M2 to M1-aCD47 macrophages. The tumor-homing of M1-aCD47 macrophages could make it possible for the delivery of aCD47 that blocked the “do not eat me” signal, thereby promoting phagocytosis of macrophages to cancer cells ( Wu et al, 2023 ).…”

Section: Tam-assisting Drug Delivery Systemmentioning

confidence: 99%

Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

Zheng,

Jiang,

et al. 2023

Front. Bioeng. Biotechnol.

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Targeting tumor-associated macrophages (TAMs) has emerged as a promising approach in cancer therapy. This article provides a comprehensive review of recent advancements in the field of nanomedicines targeting TAMs. According to the crucial role of TAMs in tumor progression, strategies to inhibit macrophage recruitment, suppress TAM survival, and transform TAM phenotypes are discussed as potential therapeutic avenues. To enhance the targeting capacity of nanomedicines, various approaches such as the use of ligands, immunoglobulins, and short peptides are explored. The utilization of live programmed macrophages, macrophage cell membrane-coated nanoparticles and macrophage-derived extracellular vesicles as drug delivery platforms is also highlighted, offering improved biocompatibility and prolonged circulation time. However, challenges remain in achieving precise targeting and controlled drug release. The heterogeneity of TAMs and the variability of surface markers pose hurdles in achieving specific recognition. Furthermore, the safety and clinical applicability of these nanomedicines requires further investigation. In conclusion, nanomedicines targeting TAMs hold great promise in cancer therapy, offering enhanced specificity and reduced side effects. Addressing the existing limitations and expanding our understanding of TAM biology will pave the way for the successful translation of these nano-therapies into clinical practice.

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Stimuli‐Mediated Macrophage Switching, Unraveling the Dynamics at the Nanoplatforms–Macrophage Interface

Ganguly,

Luthfikasari,

Randhawa

et al. 2024

Adv Healthcare Materials

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Macrophages play an essential role in immunotherapy and tissue regeneration owing to their remarkable plasticity and diverse functions. Recent bioengineering developments have focused on using external physical stimuli such as electric and magnetic fields, temperature, and compressive stress, among others, on micro/nanostructures to induce macrophage polarization, thereby increasing their therapeutic potential. However, it is difficult to find a concise review of the interaction between physical stimuli, advanced micro/nanostructures, and macrophage polarization. This review examines the present research on physical stimuli‐induced macrophage polarization on micro/nanoplatforms, emphasizing the synergistic role of fabricated structure and stimulation for advanced immunotherapy and tissue regeneration. We provide a concise overview of the research advancements investigating the impact of physical stimuli‐including electric fields, magnetic fields, compressive forces, fluid shear stress, photothermal stimuli, and multiple stimulations on the polarization of macrophages within complex engineered structures. The prospective implications of these strategies in regenerative medicine and immunotherapeutic approaches have been highlighted. This review will aid in creating stimuli‐responsive platforms for immunomodulation and tissue regeneration.This article is protected by copyright. All rights reserved

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Injectable Scaffolds for In Vivo Programmed Macrophages Manufacture and Postoperative Cancer Immunotherapy

Cited by 8 publications

References 51 publications

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

Stimuli‐Mediated Macrophage Switching, Unraveling the Dynamics at the Nanoplatforms–Macrophage Interface

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