Injectable polymer/nanomaterial composites for the fabrication of three-dimensional biomaterial scaffolds

Motealleh, Andisheh; Dorri, Pooya; Kehr, Nermin Seda

doi:10.1088/1748-605x/ab82ea

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…In this context, hydrogels based on natural polymers have been extensively studied for applications in biomedicine due to their intrinsic characteristics of biocompatibility, biodegradability, and similarities to the extracellular matrix [45,[77][78][79]. The physicochemical characteristics of biopolymeric hydrogels used in drug delivery systems, namely molecular weight, solubility, morphology, hydrophilicity, hydrophobicity, loading and release efficiency of the drug, surface energy, gelation process, etc., have been investigated [80][81][82]. Due to their natural abundance, biocompatibility, and physicochemical properties, hydrogels based on polysaccharides, specifically Alg and CS, are potentially used as drug delivery systems.…”

Section: Advantages Of Polyhy In Controlled Drug Distributionmentioning

confidence: 99%

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

2020

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In recent years, polymeric hydrogels (PolyHy) have been extensively explored for their applications in biomedicine as biosensors, in tissue engineering, diagnostic processes, and drug release. The physical and chemical properties of PolyHy indicate their potential use in regulating drug delivery. Calcineurin inhibitors, particularly cyclosporine (CsA) and tacrolimus (TAC), are two important immunosuppressor drugs prescribed upon solid organ transplants. Although these drugs have been used since the 1970s to significantly increase the survival of transplanted organs, there are concerns regarding their undesirable side effects, primarily due to their highly variable concentrations. In fact, calcineurin inhibitors lead to acute and chronic toxicities that primarily cause adverse effects such as hypertension and nephrotoxicity. It is suggested from the evidence that the encapsulation of calcineurin inhibitors into PolyHy based on polysaccharides, specifically alginate (Alg), offers effective drug delivery with a stable immunosuppressive response at the in vitro and in vivo levels. This not only may reduce the adverse effects but also would improve the adherence of the patients by the effective preservation of drug concentrations in the therapeutic ranges.

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Section: Advantages Of Polyhy In Controlled Drug Distributionmentioning

confidence: 99%

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

2020

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“…5 Scaffolding biomaterials must present the necessary mechanical, biological, and chemical cues required for promoting and guiding tissue regeneration. 6 The properties of scaffolding biomaterials could be easily tailored according to the needs of the tissues or organs to be replicated. Hydrogels are hydrated, crosslinked networks of hydrophilic polymer chains.…”

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Recent trends in gelatin methacryloyl nanocomposite hydrogels for tissue engineering

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Hossain

et al. 2021

J Biomedical Materials Res

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Gelatin methacryloyl (GelMA), a photocrosslinkable gelatin-based hydrogel, has been immensely used for diverse applications in tissue engineering and drug delivery.Apart from its excellent functionality and versatile mechanical properties, it is also suitable for a wide range of fabrication methodologies to generate tissue constructs of desired shapes and sizes. Despite its exceptional characteristics, it is predominantly limited by its weak mechanical strength, as some tissue types naturally possess high mechanical stiffness. The use of high GelMA concentrations yields high mechanical strength, but not without the compromise in its porosity, degradability, and three-dimensional (3D) cell attachment. Recently, GelMA has been blended with various natural and synthetic biomaterials to reinforce its physical properties to match with the tissue to be engineered. Among these, nanomaterials have been extensively used to form a composite with GelMA, as they increase its biological and physicochemical properties without affecting the unique characteristics of GelMA and also introduce electrical and magnetic properties. This review article presents the recent advances in the formation of hybrid GelMA nanocomposites using a variety of nanomaterials (carbon, metal, polymer, and mineral-based). We give an overview of each nanomaterial's characteristics followed by a discussion of the enhancement in GelMA's physical properties after its incorporation. Finally, we also highlight the use of each GelMA nanocomposite for different applications, such as cardiac, bone, and neural regeneration.

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Chemicals released from 3D printers and the prevention of workers’ health: a literature review

Rim

2022

Toxicol. Environ. Health Sci.

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Injectable polymer/nanomaterial composites for the fabrication of three-dimensional biomaterial scaffolds

Cited by 6 publications

References 34 publications

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

Recent trends in gelatin methacryloyl nanocomposite hydrogels for tissue engineering

Chemicals released from 3D printers and the prevention of workers’ health: a literature review

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