Injectable platelet rich fibrin therapy for androgenetic alopecia: a series of 15 cases

Bhoite, Ketki S.; Chikhalkar, Siddhi; Mishra, Sunil N; Kharkar, Vidya

doi:10.18203/issn.2455-4529.intjresdermatol20221637

Cited by 6 publications

(10 citation statements)

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“…17 Similarly, in another study, marked visible changes were reported in clinical photographs and dermoscopy after injectable-platelet rich fibrin (analogous to GFC therapy) among Indian patients with androgenetic alopecia by the end of 2 months post-therapy. 18 The hair pull test also showed a pronounced improvement as compared to the baseline result of the same which is comparable to the study performed by Steward and coworkers, in which only one (5%) out of 20 patients had an increase in hair fall in the hair pull test as compared to the results of the hair pull test done preoperatively. 19 Scalp pain during injections was the most common adverse event reported in the present study, which was related to injection pricks, followed by erythema and scalp irritation during healing.…”

Section: Discussionsupporting

confidence: 86%

Growth factor concentrate therapy for management of hair loss: a prospective, real-world study

Singh¹,

Reddy²,

Jajapuram³

2022

Int J Res Dermatol

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<p class="abstract">The present pilot study was conducted to determine the role of growth factor concentrate (GFC) therapy, a modified platelet-rich plasma (PRP) technique for the management of androgenetic alopecia. In this study, patients diagnosed with androgenic alopecia were treated with subcutaneous injections of GFC in the scalp. A total of 3 injections were administered 4 weeks apart, and the patients were followed up for 24 weeks. The treatment outcomes were assessed by taking global macroscopic photographs, trichoscopic photomicrographs, and by performing a hair pull test after 24 weeks of therapy and compared to the baseline. To determine the safety of the treatment, the incidence of any adverse event was recorded throughout the study period. The patient’s self-satisfaction was assessed using a survey-based questionnaire at the end of the study period. The global macroscopic photographs showed a significant improvement in hair growth post-GFC therapy in all 5 patients. These findings were supported by trichoscopic photomicrographs, in which a pronounced improvement in hair density along with a decrease in the shaft diameter variability and number of yellow dots were observed. Hair pull test was found to be negative in 100% of patients 4 months post-therapy. The therapy was found to be well tolerated with high patient satisfaction (80%). GFC therapy was found to have a promising role in the management of androgenetic alopecia in both male and female patients.</p>

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Section: Discussionsupporting

confidence: 86%

Growth factor concentrate therapy for management of hair loss: a prospective, real-world study

Singh¹,

Reddy²,

Jajapuram³

2022

Int J Res Dermatol

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“…Leukocyte counts: higher in low RCF Platelet counts: higher in the low and medium RCF ranges Total GFs release of PDGF-BB, TGF-β1, and EGF: higher in the low and medium RCF ranges VEGF and MMP-9: higher in the low RCF Choukroun J, et al 16 6 2400 (high), 1200 (medium), 600 (low) 8 Leukocyte and Platelet counts: higher in low RCF Total GFs release: higher in low RCF VEGF and TGF-β1: higher in the medium RCF Miron RJ, et al 3-6 min were used in most studies. 7,21,22 Two of the studies used high centrifugation speeds of 1500 and 3000 rpm for 5 and 10 min.…”

Section: Authors Cases Centrifugation Force (Rpm) Time (Min) Resultsmentioning

confidence: 99%

Platelet‐rich fibrin: A review of its role as a new treatment in androgenetic alopecia

Shrestha,

Pathak,

Jagat

et al. 2024

J of Cosmetic Dermatology

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BackgroundAndrogenetic alopecia (AGA) is a major cause of hair loss resulting from a complex interplay between various genes and hormones with the result being follicular miniaturization and altered hair cycle dynamics. Platelet‐rich plasma (PRP) has a well‐established role as adjunctive therapy in AGA but there are many limitations of it. In an attempt to overcome the shortcomings of PRP, liquid platelet‐rich fibrin (PRF) was developed.AimThis article critically reviews the protocol for the preparation and clinical outcomes of PRF.Patients/MethodsThe articles published so far in the English language regarding the preparation and clinical outcomes of PRF were reviewed.ResultsAmong five studies analyzing various centrifugation speeds and centrifugation times, three of the studies favored low‐speed centrifugation, whereas two studies did not support this methodology. A horizontal centrifuge may be preferred over a fixed‐angle centrifuge for PRF. Five clinical studies on the use of PRF showed a significant effect on AGA.ConclusionAt present, there is no consensus regarding the preparation of PRF. Most studies used fixed‐angle centrifugation favored low centrifuge speed and less centrifugation time. Larger studies are needed to determine the optimal centrifugation force and time. A horizontal centrifuge may be preferred over a fixed‐angle centrifuge due to the higher yield of platelets, and lesser shear trauma to the cells. In addition, larger, well‐designed studies are needed to confirm the benefits of PRF over PRP.

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“…This specific type of hair loss is usually addressed using FDA-approved treatments like minoxidil and oral finasteride, which have demonstrated efficacy for addressing grades 1 and 2 of hair loss. 37 However, for individuals experiencing more advanced stages of hair loss (grade 3 and beyond), additional treatment possibilities might be required. Platelet-rich plasma therapy has emerged as a frequently employed approach for promoting hair regrowth in such instances.…”

Section: Understanding Androgenic Hair Loss and Available Treatment O...mentioning

confidence: 99%

Breaking bald: Unraveling the mysteries of hair loss and modern treatments

Rathi,

Pingat,

Bhole

et al. 2024

IJCED

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Alopecia, commonly known as hair loss, presents a multifaceted challenge affecting millions worldwide. Recent advances in hair loss treatment and prevention offer hope to individuals grappling with this condition. This comprehensive overview delves into the causes of hair loss, encompassing genetics, hormonal imbalances, nutritional deficiencies, stress, and underlying medical conditions. The COVID-19 pandemic has also revealed unique patterns of hair loss i.e., telogen effluvium, prompting ongoing research and therapeutic exploration.Current treatment options, including medications like minoxidil and finasteride, surgical interventions such as hair transplants, and non-surgical techniques like laser therapy and platelet-rich plasma therapy, are examined in detail. While effective, these treatments come with limitations and potential side effects, necessitating careful consideration.Looking ahead, researchers are exploring innovative approaches to combat hair loss, from targeted medications to gene therapies and stem cell-based interventions. Advanced delivery methods using nanotechnology and biomaterials hold promise for more effective and safer solutions in the future.Recognizing the psychological impact of hair loss, this review emphasizes the importance of addressing the emotional aspects of this condition to enhance overall patient well-being. The future holds the potential for more holistic and successful treatments in the ongoing battle against hair loss, offering optimism to those seeking solutions.

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Injectable platelet rich fibrin therapy for androgenetic alopecia: a series of 15 cases

Cited by 6 publications

References 4 publications

Growth factor concentrate therapy for management of hair loss: a prospective, real-world study

Growth factor concentrate therapy for management of hair loss: a prospective, real-world study

Platelet‐rich fibrin: A review of its role as a new treatment in androgenetic alopecia

Breaking bald: Unraveling the mysteries of hair loss and modern treatments

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