Injectable platelet‐rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial

Abstract

Aim The aim of this present study was to evaluate the effect of gingival thickness (GT) and keratinized tissue width (KTW) using injectable platelet‐rich fibrin (i‐PRF) alone and with microneedling (MN) in individuals with thin periodontal phenotypes. Materials and Methods In this split‐mouth study, 33 systemically healthy patients with thin periodontal phenotypes were randomly treated with MN + i‐PRF and i‐PRF. I‐PRF was injected on one side, and MN + i‐PRF was performed on the other side of the same patient at 4 sessions with 10‐day intervals. Clinical periodontal measurements, GT and KTW were assessed before the treatment and every month for six months after the final injection. Results After the evaluation of GT between the groups, a statistically significant difference was found in MN + i‐PRF group at the sixth month. In the intra‐group comparisons, a statistically significant increase in GT was observed within both i‐PRF [from 0.43 mm ± 0.14 to 0.62 mm ± 0.11 (p < .001)] and MN + i‐PRF [from 0.4 mm ± 0.14 to 0.66 mm ± 0.12 (p < .001)] groups at the sixth month. Conclusions In individuals with thin periodontal phenotypes, standalone i‐PRF and i‐PRF with MN may have an influence in increasing GT. The results suggest that application of i‐PRF and MN may be a first step of non‐surgical method for increasing gingival thickness.

Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

“…22,23 Platelets and cytokines become trapped within the i-PRF fibrin matrix after injection leading to a slow and gradual release of growth factors over time. 19 Use of this injectable form of PRF has been reported for the treatment of various oral and maxillofacial procedures 24,25 and alopecia. 26 Limited data have been reported for its use in aesthetic skin rejuvenation.…”

Red and Yellow Injectable Platelet-Rich Fibrin Demonstrated Differential Effects on Periodontal Ligament Stem Cell Proliferation, Migration, and Osteogenic Differentiation

“…The combination has shown benefits, such as improved angiogenesis and handling ability by combining the small bone granules into a bulk material to use in bone grafting surgery [ 9 , 10 , 11 ]. Further use of i-PRF demonstrated that it was effective in regaining gingival thickness, reducing periodontal pocket depth, and attachment loss in periodontal tissue regeneration [ 12 , 13 ]. Although a few cases have reported an encouraging outcome, there has been a paradigm shift concerning the use of i-PRF in clinical bone regeneration.…”

Microneedles and Nanopatches-Based Delivery Devices in Dentistry

“…The use of microneedles independently or with grafting procedures, based on the principle of accelerated wound healing, could potentially improve the areas with thin gingival biotype. Ozsagir et al performed a clinical study where they successfully used injectable platelet-rich fibrin (I-PRF) with microneedles to enhance gingival biotype and keratinized gingiva 12 .…”