Injectable periodontal ligament stem cell-metformin-calcium phosphate scaffold for bone regeneration and vascularization in rats

Sun, Yaxi; Zhao, Zeqing; Qiao, Qingchen; Li, Shengnan; Yu, Wenting; Guan, Xiuchen; Schneider, Abraham; Weir, Michael D.; Xu, Hockin H.K.; Zhang, Ke; Bai, Yuxing

doi:10.1016/j.dental.2023.07.008

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2024

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Cited by 2 publications

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3d Bioprinting of a Calcium Phosphate Scaffold Containing Degradable Microfibers Encapsulating Hpdlscs with Two-Staged Release of Nell-1 for Bone-Vascular-Nerve Regeneration

Zhu,

Yu,

et al. 2024

Preprint

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3d Bioprinting of a Calcium Phosphate Scaffold Containing Degradable Microfibers Encapsulating Hpdlscs with Two-Staged Release of Nell-1 for Bone-Vascular-Nerve Regeneration

Zhu,

Yu,

et al. 2024

Preprint

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Vascularization Reconstruction Strategies in Craniofacial Bone Regeneration

Chen,

Da,

Yang

et al. 2024

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Craniofacial bone defects are usually secondary to accident trauma, resection of tumor, sever inflammation, and congenital disease. The defects of craniofacial bones impact esthetic appearance and functionality such as mastication, pronunciation, and facial features. During the craniofacial bone regeneration process, different osteogenic cells are introduced, including primary osteoblasts or pluripotent stem cells. However, the defect area is initially avascular, resulting in the death of the introduced cells and failed regeneration. Thus, it is vital to establish vascularization strategies to build a timely and abundant blood vessel supply network. This review paper therefore focuses on the reconstruction of both osteogenesis and vasculogenesis. The current challenges, various strategies, and latest efforts applied to enhance vascularization in craniofacial bone regeneration are discussed. These involve the application of angiogenic growth factors and cell-based vascularization strategies. In addition, surface morphology, porous characters, and the angiogenic release property of scaffolds also have a fundamental effect on vasculogenesis via cell behavior and are further discussed.

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Injectable periodontal ligament stem cell-metformin-calcium phosphate scaffold for bone regeneration and vascularization in rats

Cited by 2 publications

References 75 publications

3d Bioprinting of a Calcium Phosphate Scaffold Containing Degradable Microfibers Encapsulating Hpdlscs with Two-Staged Release of Nell-1 for Bone-Vascular-Nerve Regeneration

3d Bioprinting of a Calcium Phosphate Scaffold Containing Degradable Microfibers Encapsulating Hpdlscs with Two-Staged Release of Nell-1 for Bone-Vascular-Nerve Regeneration

Vascularization Reconstruction Strategies in Craniofacial Bone Regeneration

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